양측성 총비골신경마비 치험 1례

설재욱 ( Jae Uk Sul ),김세진 ( Se Jin Kim ),정순구 ( Sun Gu Jung ),최진봉 ( Jin Bong Choi ),김종석 ( Jong Suk Kim ) 한방재활의학과학회 2005 한방재활의학과학회지 Vol.15 No.3

Objectives: External or internal pressures on peripheral nerves may result in compression neuropathies. Although compressive common peroneal nerve palsy(CPN) is well known, very few cases with bilateral palsies have been reported. We report a 59-year-old housewife, with recent prolonged squatting, who developed acute bilateral common peroneal nerve palsy with bilateral foot-drop. Methods: We diagnosed her with nerve conduction studies(NCS) and electromyography(EMG), they were consistent with bilateral deep and superficial peroneal neuropathies, and treated her conservative maneuver as to oriental medical method. Results: Visual analogue scale is from 10 to 1. Space between the sole of the foot and floor is from 1/2 to 4/6. Conclusions: After treatment, she can do anything without discomfort, and easily flex her foot.

양혈장근건보탕(養血壯筋健步湯)과 전침의 병용치료가 손상된 척수신경 및 운동기능에 미치는 영향

설재욱 ( Jae Uk Sul ),추민규 ( Min Kyu Chu ),김선종 ( Sun Jong Kim ),최진봉 ( Jin Bong Choi ),신미숙 ( Mi Suk Shin ),김수익 ( Soo Ik Kim ) 한방재활의학과학회 2009 한방재활의학과학회지 Vol.19 No.2

Objectives: The purpose of this study was to investigate the effects of Yanghyuljanggeungunbo-tang(Yangxuezhuangjinjianbu-tang, YGKT) and electrical acupuncture treatment in spinal cord injury(SCI)-induced rats. Methods: The subjects were divided into 5 groups ; Normal, Control-no treatment after SCI, Experimental 1(Exp. 1)-taken with YGKT 500 ㎎/㎏ 0.5 ㎖ daily after SCI. Experimental 2(Exp. 2)-taken with electrical acupuncture after SCI and Experimental 3(Exp. 3)-taken with YGKT 500 ㎎/㎏ 0.5 ㎖ and electrical acupuncture after SCI. After each operation, the present author observed cytological changes, the motor behavior recovery and nerve regeneration by analysis of the motor behavior tests, EMG, hematological(AST, ALT, WBC), histological and immunological changes. Rats were tested by Motor behavior test at 1st, 3rd, 7th, 14th and 21st day. Results: 1. All the experimental groups were improved compared with control group in the motor behavior tests including Tarlov test, Basso-Beattle-Bresnahan locomotor rating scale, modified inclined plane test, open field test, grid walk test and narrow beam test. Especially Exp. 3 was significantly improved among other groups. 2. In EMG test, H and M wave were significantly increased in Exp. 3. 3. All the experimental groups were significantly decreased compared with control group in AST, ALT and WBC. 4. NGF, BDNF and Trk B of spinal cord gray matter in all the experimental groups were increased compared with control group. Especially, Exp. 3 was more effective. 5. In histological observations, muscle contraction and denaturation of gastrocnemius muscle of all the experimental groups were inhibited. Especially, those of Exp. 3 was more effective. On the observations of liver and kidney, cell atrophy and apoptosis of all the experimental groups were decreased compared with control group. Especially, those of Exp. 3 was more effective. Conclusions: It can be suggested that YGKT and electrical acupuncture may improve motor behavior, EMG, hematological, histological and immunological findings in SCI-induced rats. Especially, combination of these two treatments will be somewhat better in spinal nerve recovery and motor function improvement.

전침요법을 병용한 척추손상 환자의 치험 1례

설재욱 ( Jae Uk Sul ),신미숙 ( Mi Suk Shin ),최진봉 ( Jin Bong Choi ) 한방재활의학과학회 2004 한방재활의학과학회지 Vol.14 No.4

Objectives: A patient with spinal cord injury(SCI) is poor at prognosis. He may suffer quadriplegia, sensory paralysis or be dead. This report is a case that a patient who gets an operation for reductions and unites of cervical vertebra between 6 and 7 with SCI, gains a recovery under the treatment of rehabilitation of Oriental medicine and supplementary Acupuncture Electrical Stimulation(AES). Methods: A patient was treated with Acupuncture therapy, Acupuncture electrical stimulation(AES), Herbal medication, Depletion and cupping therapy and Oriental physical therapy. To evaluate the pain of extremity, improvement of muscle strength and ability of usual behavior, Visual Analogue Scale(VAS), Modified Barthel Index(MBI) and Manual Muscle Testing(MMT) are used. Results: Frankel Scale was changed from C7C to C7D, MBI was increased from 15 point to 75point. and MMT was improved from grade 2>3 to grade 3>4 on upper limb and from grade 3 to grade 4>5. VAS about a pain of extremity was decreased from 10 to 3. At a time of discharge from hospital, He could walk for himself within 100m with cane but the functional disability of both hands and feet, and sensory disorder of both legs was remained. Conclusions: In this case, a patient was treated by general oriental medicine and supplementary AES on the view of flaccid paralysis of limb(Wi syndrome) and he got a wide improvement of general function.

상양(商陽), 태백(太白) 보사(補瀉)가 양도락 전류 값에 미치는 영향

설재욱 ( Jae Uk Sul ),김세진 ( Se Jin Kim ),박지용 ( Ji Yong Park ),최진봉 ( Jin Bong Choi ),박용호 ( Yong Ho Park ) 한방재활의학과학회 2006 한방재활의학과학회지 Vol.16 No.2

Objectives : The purpose of this study is to observe the effect of Sangyang(LI1) and Tae-baek(SP3) acupuncture by Yangdorack. Methods : 23 subjects were examined twice before and after acupuncture from April, 2005 to September, 2005 in Oriental Medical Hospital of Dong-Shin University. After we checked the electric current on twelve points of Yangdo, and analysed the results using SPSS(Version 11.0). Results & Conclusions : 1. The values of electric current are not significant, when sorted by body mass index(BMI). But underweight testee shows increased value of electric current on heart meridian. 2. There are no differences found between right value and left value on organic analysis. 3. The mean value is elevated by Sangyang(LI1) and Tae-baek(SP3) acupuncture, the value of bi(脾) organ is significantly elevated on p<0.05.

심부정맥혈전증으로 의심되는 환자 1례에 대한 임상적 고찰

설재욱 ( Jae Uk Sul ),신미숙 ( Mi Suk Shin ),최진봉 ( Jin Bong Choi ) 한방재활의학과학회 2004 한방재활의학과학회지 Vol.14 No.2

Objective: There are a few reports and books that look upon the Damp Leg Gi as the beriberi and the polyneuritis. In this case, the patient who is suspected the DVT(Deep Vein Thrombosis), is treated by oriental medicine on the view of Damp Leg Gi, because of the clinical symptom. Methods: The patient was hospitalized Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Dong-Shin University from 18th, Oct. 2003 to 25th. Oct. 2003, and treated with Acupuncture therapy, Herbal medication, Depletion and cupping therapy and Oriental physical therapy. To evaluate the pain and edema of leg, Visual Analogue Scale(VAS) and the measurement of leg circumstance are used. Results: 1. The circumstance of the affected leg is decreased from 2.5Cm to 1±0.5Cm. 2. VAS was decreased from 9-10 to 1-2. Conclusions: In this case, the patient who is suspected the DVT(Deep Vein Thrombosis) treated by oriental medicine without a surgical operation or west medication on the view of Damp Leg Gi.

마황강활탕(麻黃羌活湯)이 Adjuvant 관절염에 미치는 실험적 효과

설재욱 ( Jae Uk Sul ),신미숙 ( Mi Suk Shin ),최진봉 ( Jin Bong Choi ) 한방재활의학과학회 2005 한방재활의학과학회지 Vol.15 No.2

Objectives : Mahwangkanghwal-tang(Mahuangqianghuo-tang;MKT) is a prescription that treat clinically arthritis. The purpose of this study is to investigate effects of MKT extract on the adjuvant arthritis in pathological rats induced by Freund`s complete adjvant(0.2 ㎖/㎏). Methods : Experimental groups were divided into 4 groups ; Normal group were administered DDW 1.0 ㎖ to normal rats for 14 days, Control group were administered DDW 1.0 ㎖ to arthritic rats for 14 days, Sample A group were administered MKT 300 ㎎/㎏ 1.0 ㎖ to arthritic rats for 14 days, Sample B group were administered MKT 500 ㎎/㎏ 1.0 ㎖ to arthritic rats for 14 days. The present author observed body weight, inhibitory effect of edema, analgesic effects by hot plate, WBC, RBC, hemoglobin, hematocrit, platelet, total serum protein level and total serum cholesterol level. Results : 1. All sample group were increased body weight compared with control group, sample B group were significantly increased body weight compared with control group. 2. All sample group significantly inhibited the rate of paw edema compared with control group. 3. All sample group significantly prolongated the escaping time compared with control group, sample B group significantly prolongated the paw licking time compared with control group. 4. All sample group were significantly decreased WBC compared with control group, sample B group were significantly decreased RBC compared with control group. 5. All sample group were decreased hemoglobin and hematocrit compared with control group. 6. All sample group were significantly decreased platelet compared with control group, sample B group were significantly decreased platelet compared with control group. 7. All sample group were significantly decreased total serum protein level compared with control group. 8. All sample group were increased total serum cholesterol compared with control group, sample B group were significantly increased total serum cholesterol level compared with control group. Conclusions : We thought that Mahwangkanghwal-tang(Mahuangqianghuo-tang) could be used for curing rheumatoid arthritis, anti-inflammatory effect was somewhat better in much than small dosage.

내장기추나요법 임상연구 문헌고찰을 통한 적응증 분석 연구

설재욱(Jae-Uk Sul),이진현(Jin-Hyun Lee),조동찬(Dong Chan Jo),황만석(Man-Suk Hwang) 척추신경추나의학회 2021 척추신경추나의학회지 Vol.16 No.2

Objectives The purpose of this study is to analyze the trend and indication of clinical research about Visceral Chuna Manipulation and to suggest the direction of further study. Methods We searched 9 electronic databases (MEDLINE Pubmed, EMBASE, CENTRAL, CiNii, CNKI, KMbase, OASIS, NDSL, KISS) using the search terms visceral manipulation , visceral manual therapy and identified relevant literature that investigated visceral manipulation as a intervention for various subjects. Results Among 142 studies were searched and screened, 16 met designated criteria. Visceral Chuna Manipulation showed the effectiveness in musculoskeletal disease, digestive disease, psychiatry, obstetrics, circulatory and oncology. Conclusions This study shows possibility of Visceral Chuna Manipulation as a treatment for many diseases. Better designed further study is necessary to establish the evidence of clinical efficacy of visceral manipulation and to suggest standard of techniques and treatment protocols for diverse patients.

교통사고 환자의 다면적 인성검사 결과 -교통사고 유형, 외상후 스트레스 장애 유무 및 성별에 따라-

설재욱 ( Jae Uk Sul ),김세진 ( Se Jin Kim ),정일문 ( Il Moon Chung ),김수연 ( Su Youn Kim ),김경옥 ( Kyeong Ok Kim ),장하정 ( Ha Jeong Jang ),최진봉 ( Jin Bong Choi ) 한방재활의학과학회 2006 한방재활의학과학회지 Vol.16 No.3

Objectives : To evaluate and find out psychological characteristics of traffic accident(TA) patients who were diagnosed as sprain of C-spine and L-spine, and suffering from psychological disorder. Methods : 35 patients wrote out Minnesota Multiphasic Personality Inventory(MMPI). We divided them into four groups according to the type of TA - car to car and car to person, posttraumatic stress disorder(PTSD) and sex. We sent medical records and MMPI reports to Dept. of Oriental Neuropsychiatry Medicine and asked who were PTSD patients. Results : 1-3/3-1 profile was found by total mean of T score of each MMPI scale in all patients. 1-3 profile was found in car to car and non-PTSD group. 3-1 profile was found in car to person and PTSD group. The difference was not valid by the type of TA, PTSD and sex(p<.05) except for the clinical scale of hysteria. Conclusions : The results indicate that MMPI characteristics of TA patients were generally 1-3/3-1 profile and patients who showed 3-1 profile must be treated more carefully because they were underlying PTSD patients.

Increased Apoptosis in Pig Parthenogenetic Fetuses Resulting Fetal Degeneration during Early Gestation Period

In-Sul Hwang,Seung-Chan Lee,Tae-Uk Kwak,Mi-Ryung Park,Sun-A Ock,Keon Bong Oh,Jae-Seok Woo,Gi-Sun Im,Seongsoo Hwang 한국동물생명공학회(구 한국동물번식학회) 2017 발생공학 국제심포지엄 및 학술대회 Vol.2017 No.10

Parthenogenetic embryo without contribution of paternal genome would be terminated during early gestation period in pigs. Therefore, the present study was designed to analyze the characteristics of parthenogenetic fetuses to identify the possible causes for fetal degeneration during early gestation period. In brief, the pig parthenogenetic fetuses were produced by embryo transfer of parthenogenetic embryos into surrogates. Then, the pig parthenogenetic fetuses were recovered at day 26 and 35 of gestation and conducted to analyze histological characteristics. In results, the parthenogenetic pig fetuses were generated and recovered at day 26 and 35 successfully. The size of parthenogenetic fetuses (n=15, 1.5 cm) recovered at day 26 of gestation were significantly smaller than normal fetuses (n=18, 2.0 cm) while the weights were comparable (0.36 vs. 0.51 g). The size and weight of parthenogenetic fetuses (n=9, 1.8 cm, 0.47 g) recovered at day 35 of gestation were significantly lower than normal fetuses (n=3, 3.67 cm, 3.71 g). The paraffin-embedded sections from parthenogenetic fetus at day 26 showed normal formation of major organs while parthenogenetic fetus at day 35 showed terminated and degenerated formation of major organs. Additionally, the apoptotic cell number of parthenogenetic fetuses (4.4) recovered at day 35 of gestation were significantly (p<0.05) higher than normal fetuses (2.0) while the result of day 26 of gestation showed comparable (1.8 vs. 2.0). Conclusively, our results can suggest that increased apoptosis in fetal tissues also leads to abnormal development of parthenogenetic pig fetus resulting delayed development until day 26 and then termination and degeneration from day 36.

Characterization of α-Gal Epitope in Cells and Tissues from Homozygous α-1,3-Galactosyltransferase Knockout Pigs

In-Sul Hwang,Dae-Jin Kwon,Tae-Uk Kwak,Keon Bong Oh,Sun-A Ock,Hak-Jae Chung,Gi-Sun Im,Seongsoo Hwang 한국동물번식학회 2015 Reproductive & developmental biology Vol.39 No.4

To overcome the hyperacute immune rejection during pig-to-non-human primates xenotranasplantation, we have produced and bred α-1,3-galactosyltransferase knock-out (GalT —/—) pigs. In this study, the somatic cells and tissues from the GalT —/— pigs were characterized by an analysis of the expression of Galα-1,3-Gal (α-Gal) epitope. Briefly, ear fibroblast cell lines of 19 homozygous GalT —/— pigs were established and cryopreserved. The expression of α-Gal epitope in the cells was measured by fluorescence activated cell sorter (FACS) analysis using BS-I-B4 lectin. Also, the homozygous (GalT —/—) cells and tissues samples were immunostained with BS-I-B4 lectin for analysis of α-Gal epitope expression. The results showed that the expression of α-Gal epitope in GalT —/— cells (0.2 %) were significantly (p< 0.05) down-regulated to the range of cynomolgus monkey fibroblast (0.2 %) cells compared to heterozygous (GalT —/+) (9.3 %) and wild type (GalT +/+) (93.7 %) fibroblast cells. In the immunostaining results, while the expression of α-Gal epitope was detected a partly in GalT —/+ cells and mostly in GalT +/+ cells, it was almost not detected in the GalT —/— cells. Also, immunostaining results from various tissues of the GalT —/— pig showed that the expression of α-Gal epitope was not detectable, whereas various tissues from GalT +/+ pig showed a strong expression of α-Gal epitope. Our results demonstrated that α-Gal epitope expressions from GalT —/— pigs were successfully knocked out to prevent hyperacute immune rejection for further study of xenotransplantation.