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Stefano Calzetti,Anna Negrotti,Vladimiro Pietrini 대한파킨슨병및이상운동질환학회 2021 Journal Of Movement Disorders Vol.14 No.3
There is a long-standing debate regarding the comorbid association of Parkinson’s disease (PD) and restless legs syndrome (RLS) in the same patients. Recently, many studies have been focused mainly on the differentiation of the RLS cooccurring with PD from the primary form of the sensory-motor disorder [1], whereas possible heterogeneity in the pathomechanisms of RLS related to the timing of its onset in respect to the clinically overt PD and the so-called premotor/prodromal PD remains as yet unexplored.