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RISS 인기검색어
- 검색키워드
- 저자 : Stacey R. Froemming (검색결과 2 건)
- 무료
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Shijia Zhao,Linxia Gu,Stacey R. Froemming 대한의용생체공학회 2012 Biomedical Engineering Letters (BMEL) Vol.2 No.3
Purpose In-stenting restenosis is one of the major complications after stenting. Clinical trials of various stent designs have reported different restenosis rates. However,quantitative correlation between stent features and restenosis statistics is scant. In this work, it is hypothesized that stress concentrations on arterial wall caused artery injury, which initiates restenosis. The goal is to assess the correlation between stent-induced arterial stress and strain and the documented restenosis rates. Methods Six commercially available stents, including balloon-expandable stents and self-expanding stents, were virtually implanted into the arteries through finite element method. The resulted peak Von Mises stress, principal stress,principal logarithm strain, as well as percentage of intimal area with abnormal higher stress were monitored. Results Positive correlation between arterial stress and strain after stent implantations and the documented restenosis rates from the corresponding clinical trials was found regardless of stent types. No statistical significant difference was observed for various stress or strain parameters serving as indicators of artery injury. Conclusions In-stent restenosis are less likely to occur as arterial mechanics are least altered by stent implantations. Optimization of stent designs to minimize the stent-induced arterial stresses and strains can reduce the arterial injury, and thus reduce the occurrence of restenosis. This work improved our understanding of the stent-lesion interactions that regulate arterial mechanics and demonstrated that arterial stress and strain could predict the risk of in-stent restenosis.
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Assessment of Shape Memory Alloy Stent Deployment in a Stenosed Artery
Linxia Gu,Shijia Zhao,Stacey R. Froemming 대한의용생체공학회 2011 Biomedical Engineering Letters (BMEL) Vol.1 No.4
Purpose Shape memory alloy (SMA) stents have been used increasingly for the treatment of complex arterial occlusions. There is an immediate need to quantify the mechanical performance of SMA stents to open occluded arteries. Methods The stent crimping and expanding process was assessed through both numerical modeling and in-vitro studies. The implantation of a SMA stent in curved arteries with eccentric stenosis were simulated to evaluate the effect of artery curvature on arterial mechanics. Results The crimping process stored a considerable amount of strain energy in the stent, which were then released through self-expansion until a balance between the stent and stenosed artery was achieved. The deployed SMA stent exhibited a dog-bone shape, where the longitudinal ends of the stent penetrated into the artery causing arterial stress concentrations. However, the maximum arterial stress was observed at the central portion of artery contacting the thin side of the plaque. Furthermore, stent-induced arterial mechanics were more pronounced in the curved artery than the straight artery. The maximum Von Mises stress in the curved artery with a curvature of 0.05 mm-1 was 37% larger than that found in the straight artery. The percentage of the intimal area at higher stress level (> 0.05 MPa) is 5.51% in the curved artery, compared to 1.76% in the straight artery. Conclusions This work provided a fundamental understanding of the behavior of SMA stent and its impact on the vascular wall, and illuminated the possibilities for exploiting their potential to alleviate arterial injury.
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