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- 저자 : St. Gelais, C. (검색결과 1 건)
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SAMHD1 controls cell cycle status, apoptosis and HIV-1 infection in monocytic THP-1 cells
Bonifati, S.,Daly, M.B.,St. Gelais, C.,Kim, S.H.,Hollenbaugh, J.A.,Shepard, C.,Kennedy, E.M.,Kim, Dong.Hyun.,Schinazi, R.F.,Kim, B.,Wu, L. 3M Company 2016 Virology Vol.495 No.-
<P>SAMHD1 limits HIV-1 infection in non-dividing myeloid cells by decreasing intracellular dNTP pools. HIV-1 restriction by SAMHD1 in these cells likely prevents activation of antiviral immune responses and modulates viral pathogenesis, thus highlighting a critical role of SAMHD1 in HIV-1 physiopathology. Here, we explored the function of SAMHD1 in regulating cell proliferation, cell cycle progression and apoptosis in monocytic THP-1 cells. Using the CRISPR/Cas9 technology, we generated THP-1 cells with stable SAMHD1 knockout. We found that silencing of SAMHD1 in cycling cells stimulates cell proliferation, redistributes cell cycle population in the G(1)/G(0) phase and reduces apoptosis. These alterations correlated with increased dNTP levels and more efficient HIV-1 infection in dividing SAMHD1 knockout cells relative to control. Our results suggest that SAMHD1, through its dNTPase activity, affects cell proliferation, cell cycle distribution and apoptosis, and emphasize a key role of SAMHD1 in the interplay between cell cycle regulation and HIV-1 infection. (C) 2016 Elsevier Inc. All rights reserved.</P>
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