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Shakya, Ashok K.,Mishra, Pradeep,Patnaik, G.K.,Shukla, Rakesh,Srimal, R.C. The Pharmaceutical Society of Korea 1998 Archives of Pharmacal Research Vol.21 No.6
Sixteen novel 2-substituted acetyl amino-5-alkyl-1,3,4-thiadiazol were synthesized and screened for their pharmacological activities. A few of the compounds namely 11, 12 and 16 showed anti-inflammatory activities comparable to phenylbutazone. Compound 12 also showed significan non-specific spasmolytic activity. Diuretic activity of compound 15 at a dose level of 90mg/kg p.o. was two fold higher compared to 50mg/kg p.o. of furosemide. Comparable diuresis was aso produced by compounds 9, 10, and 16.