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Sulowski Maciej,Cias Andrzej,Frydrych Hanna,Frydrych Jerzy,Olszewska Irena,Golen Ryszard,Sowa Marek 한국분말야금학회 2006 한국분말야금학회 학술대회논문집 Vol.2006 No.1
The effect of different cooling rate on the structure and mechanical properties of Fe-3%Mn-(Cr)-(Mo)-0.3%C steels is described. Pre-alloyed Astaloy CrM and CrL, ferromanganese and graphite were used as the starting powders. Following pressing in a rigid die, compacts were sintered at and in atmospheres and cooled with cooling rates and . Convective cooled specimens were subsequently tempered at for 60 and 240 minutes.
Solek Przemyslaw,Mytych Jennifer,Sujkowska Ewelina,Grzegorczyk Magdalena,Jasiewicz Patrycja,Sowa-Kucma Magdalena,Stachowicz Katarzyna,Koziorowski Marek,Tabecka-Lonczynska Anna 한국독성학회 2022 Toxicological Research Vol.38 No.2
The increasing number of depression cases leads to a greater need for new antidepressant treatment development. It is postulated that antidepressants may harm male fertility, but the cellular mechanism is still poorly understood. The role of growth factors and klotho protein in maintaining normal male reproductive function is well documented. Hence, the study aimed to investigate the effect of the antidepressant drug – imipramine (tricyclic AD), and other substances with antidepressant potential (ALS), administered in combination or in combination with LPS (an animal model of depression) on gene expression and protein synthesis of IGF-2 (insulin-like growth factor 2), TGF-β1 (transforming growth factor β1), NGF (nerve growth factor), KGF (keratinocyte growth factor) and protein synthesis of VEGF-A (vascular endothelial growth factor A), IGF-IR (insulin-like growth factor receptor 1), EGFR (epidermal growth factor receptor) and klotho in the testis of mice. Mice were injected intraperitoneally with selected ALS and LPS or 10% DMSO (controls) (n = 7/group) once a day for 14 days. Animals were decapitated and testes collected for RNA and protein purification. PCR and western blot methods were employed for the evaluation of growth factors and klotho expression. The results obtained indicated a decreased level of most of the analyzed genes and proteins, except KGF; its expression increased after treatment with MTEP and IMI administrated individually and after NS-398, and IMI in combination with LPS. Our results may suggest that the tested ALS and LPS can contribute to a reduction of male fertility, but NS-398, IMI, and IMI+NS-398 may also act as stimulants after LPS.