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- 저자 : Sinan Deniz (검색결과 5 건)
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Deniz Akta Uygun,Nevra Öztürk,Sinan Akgöl,Adil Denizli 한국생물공학회 2011 Biotechnology and Bioprocess Engineering Vol.16 No.1
A new metal-chelate adsorbent utilizing 2-methacryloylamidohistidine (MAH) was prepared as a metalchelating ligand. MAH was synthesized using methacryloly chloride and histidine. Monosize nanospheres with an average diameter of 450 nm were produced by emulsion polymerization of 2-hydroxyetylmethacrylate (HEMA) and MAH. Then, Fe^(3+) ions were chelated directly onto the monosize nanospheres. Mon-poly(HEMA-MAH) nanospheres were characterized by Fourier transform infrared spectroscopy,scanning electron microscopy, and elemental analysis. Fe^(3+) chelated monosize nanospheres were used in ferritin adsorption from an aqueous solution. The maximum ferritin adsorption capacity of Fe^(3+)-chelated mon-poly(HEMAMAH)nanospheres was 202 mg/g at pH 4.0 in acetate buffer. The non-specific ferritin adsorption on the monpoly(HEMA-MAH) nanospheres was 20 mg/g. The adsorption behavior of ferritin could be modeled using both Langmuir and Freundlich isotherms. The adsorption capacity decreased with increasing ionic strength of the binding buffer. High desorption ratios (> 95% of the adsorbed ferritin) were achieved with 1.0 M NaCl at pH 7.0. Ferritin could be repeatedly adsorbed and desorbed with the Fe^(3+)-chelated mon-poly(HEMA-MAH) nanospheres without significant loss of adsorption capacity.
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NEW ANALYTIC APPROXIMATE SOLUTIONS TO THE GENERALIZED REGULARIZED LONG WAVE EQUATIONS
Bildik, Necdet,Deniz, Sinan Korean Mathematical Society 2018 대한수학회보 Vol.55 No.3
In this paper, the new optimal perturbation iteration method has been applied to solve the generalized regularized long wave equation. Comparing the new analytic approximate solutions with the known exact solutions reveals that the proposed technique is extremely accurate and effective in solving nonlinear wave equations. We also show that,unlike many other methods in literature, this method converges rapidly to exact solutions at lower order of approximations.
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New analytic approximate solutions to the generalized regularized long wave equations
Necdet Bildik,Sinan Deniz 대한수학회 2018 대한수학회보 Vol.55 No.3
In this paper, the new optimal perturbation iteration method has been applied to solve the generalized regularized long wave equation. Comparing the new analytic approximate solutions with the known exact solutions reveals that the proposed technique is extremely accurate and effective in solving nonlinear wave equations. We also show that,unlike many other methods in literature, this method converges rapidly to exact solutions at lower order of approximations.
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Chemopreventive Effects of Hydatid Disease on Experimental Breast Cancer
Altun, Ahmet,Saraydin, Serpil Unver,Soylu, Sinan,Inan, Deniz Sahin,Yasti, Cinar,Ozdenkaya, Yasar,Koksal, Binnur,Duger, Cevdet,Isbir, Cemil,Turan, Mustafa Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.4
Breast cancer is one of the most common and letal cancers in all over the world. Since there have been significant improvements in treatment of breast cancer, there is still a big need for alternative approaches. In this study, we aimed to investigate protective role of hydatid disease against breast cancer. Twenty Wistar rats were divided into two groups of 10 rats each Group I (control) and Group II. In Group II intraperitoneal hydatidosis was performed. Then DMBA was applied to mammary tissues of all rats. Immunohistochemistry studies for Ki-67 and S-100 in the tumoral tissue sections of DMBA induced mammary tumor in rats were performed. TUNEL Assay was used to detect apoptotic cells of tumoral tissue. In vivo anticancer activity testing was carried out by preventing the tumorigenesis by DMBA in mammary tissue of rats. The expressions of the Ki-67 and S-100 protein decreased in rats who had Hydatid Disease (HD) (Group II), compared with the control rats (Group I). TUNEL positive cells were higher in rats with HD (Group II), compared with the control rats (Group I). In vivo studies showed that HD prevented the tumorigenesis by DMBA in mammary tissue of rats with 50 percent.In the light of the evidence the present study showed that HD may have chemopreventive effects on DMBA induced breast cancer.
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Mehmet Giray Sonmez,Betul Kozanhan,Çigdem Damla Deniz,Mehmet Sinan Iyisoy,Muzaffer Tansel Kilinc,Gokhan Ecer,Ahmet Ozturk,Salim Neselioglu,Ozcan Erel 대한비뇨의학회 2019 Investigative and Clinical Urology Vol.60 No.4
Purpose: A dynamic thiol/disulfide balance is pivotal in organizing anti-oxidant defense, detoxification, apoptosis, and enzyme activities, as well as transcription and cellular signal-transfer mechanisms. The connection between urolithiasis and oxidant/antioxidant status, which can be assessed through thiol-disulfide homeostasis (TDH), has not yet been examined. In this study, we evaluated the effects of TDH on the formation, size, and location of stones by examining the associations between TDH parameters and urolithiasis. Materials and Methods: Patients with urolithiasis and healthy controls were recruited. The patients were divided into subgroups in terms of stone size (>15 mm or ≤15 mm) and stone location (nephrolithiasis or ureterolithiasis). TDH parameters were measured using a novel automatic and spectrophotometric method and compared statistically. Results: TDH parameters were different between the urolithiasis and control groups. TDH tended towards the disulfide side in the urolithiasis group. Stone size increased an average 0.14 mm with a 1 µmol/L increase in disulfide level and decreased an average 0.058 mm with a 1 µmol/L increase in native thiol level. Disulfide and native thiol levels were found to be different across patients with stone size >15 mm, ≤15 mm, and controls (p<0.001 and p<0.001, respectively). However, the nephrolithiasis and ureterolithiasis groups were similar in respect of TDH parameters. Conclusions: In this study, it was found that patients with urolithiasis displayed oxidative stress characterized by a TDH tendency towards the disulfide side, and an inadequate antioxidant response identified by a lower level of native thiol as compared with healthy controls.
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