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RISS 인기검색어
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- 저자 : Siddhartha Tripathi (검색결과 2 건)
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Disease diagnostics using hydrodynamic flow focusing in microfl uidic devices: Beyond flow cytometry
Aakash Rajawat,Siddhartha Tripathi 대한의용생체공학회 2020 Biomedical Engineering Letters (BMEL) Vol.10 No.2
The multi-disciplinary fi eld of microfl uidics has the potential to provide solutions to a diverse set of problems. It off ers theadvantages of high-throughput, continuous, rapid and expeditious analysis requiring minute quantities of sample. However,even as this fi eld has yielded many mass-manufacturable and cost-effi cient point-of-care devices, its direct and practicalapplications into the fi eld of disease diagnostics still remain limited and largely overlooked by the industry. This reviewfocuses on the phenomenon of hydrodynamic focusing and its potential to materialize solutions for appropriate diagnosisand prognosis. The study aims to look beyond its intended cytometric applications and focus on unambiguous disease detection,monitoring, drug delivery, studies conducted on DNA and highlight the instances in the scientifi c literature that haveproposed such approach.
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Sanjay Mane,Vadiraj Hemadri,Siddhartha Tripathi 한국바이오칩학회 2022 BioChip Journal Vol.16 No.3
White blood cells (WBCs) provide crucial information pertaining to human health, and its separation from other blood constituents is imperative for blood-based diagnostics of various pathological conditions. However, efficient WBC separation and enrichment remain to be a challenge. We propose a novel mechanism of WBC separation in a microfluidic device using centrifugal forces, inertial forces, and diluted human blood prepared with hypertonic saline solution. Herein, a simple wavy type microchannel called the separation channel was designed to separate and enrich WBCs. Almost 88% of WBCs were separated with a purity of 83% with diluted blood, i.e., hematocrit (Hct) 2.8% prepared using a 10% hypertonic solution. In addition, the effect of hematocrit and flow rate on WBC separation is also reported in this work. The proposed microdevice can be used for enrichment and separation of WBCs and also develop a better understanding of the interactions amongst blood cells with altered properties.
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