http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Shteinfer-Kuzmine, Anna (검색결과 1 건)
- 무료
- 기관 내 무료
- 유료
-
VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease
Kim, Jeonghan,Gupta, Rajeev,Blanco, Luz P.,Yang, Shutong,Shteinfer-Kuzmine, Anna,Wang, Kening,Zhu, Jun,Yoon, Hee Eun,Wang, Xinghao,Kerkhofs, Martijn,Kang, Hyeog,Brown, Alexandra L.,Park, Sung-Jun,Xu, American Association for the Advancement of Scienc 2019 Science Vol.366 No.6472
<P><B>VDACs are MOM's ruin</B></P><P>Mitochondrial DNA (mtDNA) is normally kept within the mitochondria. It can be released into the cytosol in response to stress and thus encounter cytosolic DNA sensors, triggering type I interferon responses. During apoptosis, mtDNA release is mediated by macropores in the mitochondrial outer membrane (MOM) created by oligomerization of the proteins BAX and BAK. Kim <I>et al.</I> found that during oxidative stress, mtDNA escapes instead through macropores formed by oligomerization of voltage-dependent anion channels (VDACs) (see the Perspective by Crow). In a mouse model of lupus, an inhibitor of VDAC oligomerization diminished mtDNA release and downstream signaling events. This treatment reduced lupus-like symptoms in the model, suggesting a potential therapeutic route for conditions mediated by mtDNA release.</P><P><I>Science</I>, this issue p. 1531; see also p. 1445</P><P>Mitochondrial stress releases mitochondrial DNA (mtDNA) into the cytosol, thereby triggering the type Ι interferon (IFN) response. Mitochondrial outer membrane permeabilization, which is required for mtDNA release, has been extensively studied in apoptotic cells, but little is known about its role in live cells. We found that oxidatively stressed mitochondria release short mtDNA fragments via pores formed by the voltage-dependent anion channel (VDAC) oligomers in the mitochondrial outer membrane. Furthermore, the positively charged residues in the N-terminal domain of VDAC1 interact with mtDNA, promoting VDAC1 oligomerization. The VDAC oligomerization inhibitor VBIT-4 decreases mtDNA release, IFN signaling, neutrophil extracellular traps, and disease severity in a mouse model of systemic lupus erythematosus. Thus, inhibiting VDAC oligomerization is a potential therapeutic approach for diseases associated with mtDNA release.</P>
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
