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- 저자 : Shokoh Parham (검색결과 1 건)
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Parisa Heydari,Shokoh Parham,Anousheh Zargar Kharazi,Shaghayegh Haghjooy Javanmard,Seddigheh Asgary 한국섬유공학회 2022 Fibers and polymers Vol.23 No.9
Biomaterial selection is one of the important factors in tissue engineering vascular graft (TEVG) because of itshemocompatibility, mechanical properties, and biodegradability. In the present research, we prepared the bilayer electrospunscaffolds from poly glycerol sebacate (PGS)/poly caprolactone (PCL) and poly glycerol sebacate (PGS)/poly lactic acid(PLA), Then the surface of both groups was modified by using oxygen plasma. Physical, mechanical and hemocompatibilityevaluation of the bilayer PGS/PCL and PGS/PLA scaffold was performed to introduce a more suitable combination forTEVG applications. Results demonstrated that the plasma treatment process did not affect the surface morphology ofelectrospinning fibers but improved hydrophilicity, swelling ratio, and blood compatibility. It caused a faster degradation ratein treated groups. Mechanical tests of these scaffolds showed a proper mechanical strength for vascular tissue engineeringbefore and after plasma treatment, however, elongation of the PGS/PCL scaffolds was more suitable for vascular graftapplications. The hemocompatibility study showed improvement in platelet adhesion, hemolysis, and blood clotting timeafter plasma treatment in both groups also, there was no significant difference between the two scaffolds inhemocompatibility characteristics. It concluded that the treated bilayer PGS/PCL scaffold can be more suitable for vasculargraft application.
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