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RISS 인기검색어
- 검색키워드
- 저자 : Shi-Zheng Huang (검색결과 27 건)
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Shi, Liang,Chen, Zhan-Guo,Wu, Li-li,Zheng, Jian-Jian,Yang, Jian-Rong,Chen, Xiao-Fei,Chen, Zeng-Qiang,Liu, Cun-Li,Chi, Sheng-Ying,Zheng, Jia-Ying,Huang, Hai-Xia,Lin, Xiang-Yang,Zheng, Fang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.23
Many chemotherapeutic agents have been successfully used to treat hepatocellular carcinoma (HCC); however, the development of chemoresistance in liver cancer cells usually results in a relapse and worsening of prognosis. It has been demonstrated that DNA methylation and histone modification play crucial roles in chemotherapy resistance. Currently, extensive research has shown that there is another potential mechanism of gene expression control, which is mediated through the function of short noncoding RNAs, especially for microRNAs (miRNAs), but little is known about their roles in cancer cell drug resistance. In present study, by taking advantage of miRNA effects on the resistance of human hepatocellular carcinoma cells line to cisplatin, it has been demonstrated that miR-340 were significantly downregulated whereas Nrf2 was upregulated in HepG2/CDDP (cisplatin) cells, compared with parental HepG2 cells. Bioinformatics analysis and luciferase assays of Nrf2-3'-untranslated region-based reporter constructor indicated that Nrf2 was the direct target gene of miR-340, miR-340 mimics suppressing Nrf2-dependent antioxidant pathway and enhancing the sensitivity of HepG2/CDDP cells to cisplatin. Interestingly, transfection with miR-340 mimics combined with miR-340 inhibitors reactivated the Nrf2 related pathway and restored the resistance of HepG2/CDDP cells to CDDP. Collectively, the results first suggested that lower expression of miR-340 is involved in the development of CDDP resistance in hepatocellular carcinoma cell line, at least partly due to regulating Nrf2-dependent antioxidant pathway.
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Huang, Yue-Han,Chen, Zhen-Kun,Huang, Ka-Te,Li, Peng,He, Bin,Guo, Xu,Zhong, Jun-Qiao,Zhang, Qi-Yu,Shi, Hong-Qi,Song, Qi-Tong,Yu, Zheng-Ping,Shan, Yun-Feng Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3
Aim: To study any correlation of LKB1 expression with prognosis in hepatocellular carcinoma (HCC) cases. Methods: A total of 70 HCC patients and 20 primary intrahepatic stone patients in the first affiliated hospital of Wenzhou Medical College were enrolled in this study. LKB1 expression was detected by immunohistochemistry. Patients were followed-up and prognostic factors were evaluated. Result: LKB1 expression was decreased in the HCC samples. Loss of LKB1 expression in HCC was significantly related to histologic grade (P=0.010), vascular invasion (P=0.025) and TMN stage (P=0.011). Patients showing negative LKB1 expression had a significantly shorter disease-free and overall survival than those with positive expression (P = 0.001, P=0.000, respectively). Multivariate Cox regression analysis indicated that LKB1 expression level was an independent factor of survival (P = 0.033). Conclusion: HCC patients with decreased expression LKB1 have a poor prognosis. The loss of LKB1 expression is correlated with a lower survival rate.
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Zheng, Feng-Jin,Shi, Lin,Yang, Jun,Deng, Xiao-Hui,Wu, Yu-Quan,Yan, Xi-Qing,Huang, Ning Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.8
Aim: Tea polyphenols are known to play roles in critical steps of human lung carcinoma cell metastasis. For understanding the mechanisms whereby they inhibit tumor metastasis, the present study was conducted to investigate their effects on the adhesion of highly metastatic lung carcinoma cell lines (PG cells) to endothelial cells (EC cells) and adhesion molecule expression in vitro. Methods: The expression of CD44 or CD54 in the PG cells was detected by flow cytometry and adhesion of PG cells to EC cells was assessed by confocal microscopy double fluorescence staining. Results: The results showed that tea polyphenols: (1) inhibited the expression of CD44 and CD54, two important adhesion molecules in the PG cells in a dose-dependent manner; (2) significantly blocked the adhesion of PG cells to EC cells not only in a state of rest but also when active; and (3) influenced CD44 and CD54 expression during the adhesion process of PG cells to EC cells. Conclusions: The data indicated that the blocking role of tea polyphenols in the adhesion of PG cells to EC cells is related to CD44 and CD54. The mechanism of tea polyphenol prevention of human lung carcinoma metastasis might be through inhibiting adhesion molecule expression to block cancer cell adhesion.
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Shi, Liang,Wu, Li-Li,Yang, Jian-Rong,Chen, Xiao-Fei,Zhang, Yi,Chen, Zeng-Qiang,Liu, Cun-Li,Chi, Sheng-Ying,Zheng, Jia-Ying,Huang, Hai-Xia,Yu, Fu-Jun,Lin, Xiang-Yang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7
Background: Recently, peroxiredoxin3 (PRDX3) was identified as a novel molecular marker for the progression of hepatocellular carcinoma (HCC). However, its potential clinical application as a serum marker for the early diagnosis and prognosis of HCC has not been investigated. Methods: PRDX3, alpha-fetaprotein (AFP), and other biochemical parameters were measured in serum samples from 297 Chinese patients, including 96 with HCC, 98 with liver cirrhosis (LC), and 103 healthy controls (HCs). Correlations between serum PRDX3 expression and clinicopathological variables and the relationship between serum PRDX3 expression and prognosis were analyzed. Results: Serum PRDX3 was significantly higher in HCC patients than in the LC and HC groups. The sensitivity and specificity of serum PRDX3 for the diagnosis of HCC were 85.9% and 75.3%, respectively, at a cutoff of 153.26 ng/mL, and the area under the curve was 0.865. Moreover, serum PRDX3 expression was strongly associated with AFP level, tumor diameter, TNM stage, and portal vein invasion. Kaplan-Meier curve analysis revealed that HCC patients with high serum PRDX3 expression had a shorter median survival time than those with low PRDX3 expression. Moreover, serum PRDX3 expression was an independent risk factor for overall survival. The inverse correlation between serum PRDX3 and patient survival remained significant in patients with early-stage HCC and in those with normal serum AFP levels. Conclusions: Serum PRDX3 can be used as a noninvasive biomarker for the diagnosis and/or prognosis of HCC.
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Current Decoupling Scheme of Three-Phase Inverter with Complex Coefficient Controller
Zheng Xinxin,Xu Jianjun,Shi Jingkui,Huang Wenxin,Li Qiyue 대한전기학회 2022 Journal of Electrical Engineering & Technology Vol.17 No.6
In the control of three-phase system, AC signals are always changed into DC signals by synchronous coordinate transformation. A decoupling control scheme in the dq synchronous reference frame (SRF) is proposed to realize active and reactive current decoupling of three-phase inverter. The complex vector control model is established in SRF. Diff erent from the model established in static reference frame, the SRF control model can refl ect the coupling characteristic of the active and reactive current. As a result, the PI controller with complex coeffi cient can be applied to realize current decoupling. In this paper, the coupling characteristic of three-phase system is analyzed. A novel complex PI controller design method is proposed based on the SRF control model and the coeffi cients are calculated. And its implementation in the control loop is given. Compared with existing PI controllers with real or complex coeffi cients, the proposed complex PI controller can realize completely the decoupling of the active and reactive current in three-phase system. Besides, the control scheme can make current loop fulfi ll the expected symmetrical bandwidth, so as to realize a higher eff ective set-off frequency. As a result, the inverter can achieve well dynamic performance. Finally, the simulation and experimental results are given to verify the theoretical analysis.
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Shi, X.,Wang, J.,Liu, J.,Huang, S.,Wu, X.,Chen, C.,Lu, J.,Su, Y.,Zheng, Y.,Kim, W.Y.,He, G. Elsevier Science 2014 Organic electronics Vol.15 No.4
We have successfully applied finite-difference time-domain (FDTD) method in top-emitting organic light-emitting diodes (TOLEDs) for structure optimization, demonstrating good agreement with experimental data. A mixed host with both hole transport and electron transport materials is employed for the green phosphorescent emitter to avoid charge accumulation and broaden the recombination zone. The resulting TOLEDs exhibit ultra-high efficiencies, low current efficiency roll-off, and a highly saturated color, as well as hardly detectable spectrum shift with viewing angles. In particular, a current efficiency of 127.0cd/A at a luminance of 1000cd/m<SUP>2</SUP> is obtained, and maintains to 116.3cd/A at 10,000cd/m<SUP>2</SUP>.
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Zheng Zeng,Jia-Qiang Yang,Shi-Lan Chen,Jin Huang 전력전자학회 2014 JOURNAL OF POWER ELECTRONICS Vol.14 No.2
A fast-transient repetitive control strategy for a three-phase shunt active power filter is presented in this study to improve dynamic performance without sacrificing steady-state accuracy. The proposed approach requires one-sixth of the fundamental period required by conventional repetitive control methods as the repetitive control time delay in the synchronous reference frames. Therefore, the proposed method allows the system to achieve a fast dynamic response, and the program occupies minimal storage space. A proportional-integral regulator is also added to the current control loop to eliminate arbitrary-order harmonics and ensure system stability under severe harmonic distortion conditions. The design process of the corrector in the fast-transient repetitive controller is also presented in detail. The LCL filter resonance problem is avoided by the appropriately designed corrector, which increases the margin of system stability and maintains the original compensation current tracking accuracy. Finally, experimental results are presented to verify the feasibility of the proposed strategy.
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DC Bus Voltage Stabilization Control Considering Power Loss of the Full-Quadrant Operated Inverter
Shi Jingkui,Huang Wenxin,Zheng Xinxin,Li Qiyue 대한전기학회 2021 Journal of Electrical Engineering & Technology Vol.16 No.6
This paper proposed a DC bus voltage stabilization control strategy of the full-quadrant operated three-phase grid-connected inverter, of which the reactive current is not 0. The strategy considers the power loss of the switches caused by both active and reactive current, which would aff ect the dynamic performance of voltage loop. In this condition, the power loss can be seen as a disturbance of the voltage loop so it should be taken into consideration in the design process. Besides, the voltage loop is the outer loop of the active current loop. The active and reactive current are coupled because of the coordinate transformation. As a result, the interference of the reactive current would aff ect the DC bus voltage through current coupling. The proposed control strategy considers the power loss and designs the outer voltage loop. Also the decoupling current controller based on complex vectors is discussed. With the proposed DC bus voltage stabilization strategy, the inverter can realize good dynamic and static performances. The control principle is analyzed in detail. The design of the control loops are discussed. The infl uences of the reactive current on the DC voltage and active current are analyzed. Finally, the simulation and experimental results verify the theoretical analysis.
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Shi, Xueliang,Quintero, Estefaní,a,Lee, Sangsu,Jing, Linzhi,Herng, Tun Seng,Zheng, Bin,Huang, Kuo-Wei,Ló,pez Navarrete, Juan T.,Ding, Jun,Kim, Dongho,Casado, Juan,Chi, Chunyan Royal Society of Chemistry 2016 Chemical Science Vol.7 No.5
<▼1><P>Pro-aromatic <B>Th<I>n</I>-TIPS</B> exhibits distinctly different physical properties from anti-aromatic <B>S<I>n</I>-TIPS</B>.</P></▼1><▼2><P>Open-shell singlet diradicaloids have recently received much attention due to their unique optical, electronic and magnetic properties and promising applications in materials science. Among various diradicaloids, quinoidal π-conjugated molecules have become the prevailing design. However, the need for a fundamental understanding on how the fusion mode and pro-aromaticity/anti-aromaticity affect their diradical character and physical properties remains unaddressed. In this work, a series of pro-aromatic benzo-thia-fused [<I>n</I>]thienoacenequinodimethanes (<B>Th<I>n</I>-TIPS</B> (<I>n</I> = 1–3) and <B>BDTh-TIPS</B>) were synthesized and compared with the previously reported anti-aromatic bisindeno-[<I>n</I>]thienoacenes (<B>S<I>n</I>-TIPS</B>, <I>n</I> = 1–4). The ground-state geometric and electronic structures of these new quinoidal molecules were systematically investigated by X-ray crystallographic analysis, variable temperature NMR, ESR, SQUID, Raman, and electronic absorption spectroscopy, assisted by DFT calculations. It was found that the diradical character index (<I>y</I><SUB>0</SUB>) increased from nearly zero for <B>Th1-TIPS</B> to 2.4% for <B>Th2-TIPS</B>, 18.2% for <B>Th3-TIPS</B>, and 38.2% for <B>BDTh-TIPS</B>, due to the enhanced aromatic stabilization. Consequently, with the extension of molecular size, the one-photon absorption spectra are gradually red-shifted, the two-photon absorption (TPA) cross section values increase, and the singlet excited state lifetimes decrease. By comparison with the corresponding anti-aromatic analogues <B>S<I>n</I>-TIPS</B> (<I>n</I> = 1–3), the pro-aromatic <B>Th<I>n</I>-TIPS</B> (<I>n</I> = 1–3) exhibit larger diradical character, longer singlet excited state lifetime and larger TPA cross section value. At the same time, they display distinctively different electronic absorption spectra and improved electrochemical amphotericity. Spectroelectrochemical studies revealed a good linear relationship between the optical energy gaps and the molecular length in the neutral, radical cationic and dicationic forms. Our research work discloses a significant difference between the pro-aromatic and anti-aromatic quinoidal compounds and provides guidance for the design of new diradicaloids with desirable properties.</P></▼2>
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