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RISS 인기검색어
- 검색키워드
- 저자 : Sheth Komal (검색결과 3 건)
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Sheth Komal,Banga Kulvinder Singh,Pawar Ajinkya M.,Gutmann James L.,Kim Hyeon-Cheol 대한치과보존학회 2022 Restorative Dentistry & Endodontics Vol.47 No.1
Objectives This study assessed the shape and anatomical relationship of the mental foramen (MF) to mandibular posterior teeth in an Indian sub-population. Materials and Methods In total, 475 existing cone-beam computed tomography records exhibiting 950 MFs and including the bilateral presence of mandibular premolars and first molars were assessed. Images were evaluated 3-dimensionally to ascertain the position, shape, and anatomical proximity of MFs to mandibular teeth. The position and shape of MFs were measured and calculated. The Pythagorean theorem was used to calculate the distance between the root apex of the mandibular teeth and the MF. Results MFs exhibited a predominantly round shape (left: 67% and right: 65%) followed by oval (left: 30% and right: 31%) in both males and females and in different age groups. The root apices of mandibular second premolars (left: 71% and right: 62%) were closest to the MF, followed by distal to the first premolars and mesial to the second premolars. The mean vertical distance between the MF and the nearest tooth apex calculated on sagittal sections was 2.20 mm on the right side and 2.32 mm on the left side; no significant difference was found according to sex or age. The distance between the apices of the teeth and the MF was ≥ 4 mm (left; 4.09 ± 1.27 mm and right; 4.01 ± 1.15 mm). Conclusions These findings highlight the need for clinicians to be aware of the location of the MF in treatment planning and while performing non-surgical and surgical endodontic procedures. Objectives This study assessed the shape and anatomical relationship of the mental foramen (MF) to mandibular posterior teeth in an Indian sub-population. Materials and Methods In total, 475 existing cone-beam computed tomography records exhibiting 950 MFs and including the bilateral presence of mandibular premolars and first molars were assessed. Images were evaluated 3-dimensionally to ascertain the position, shape, and anatomical proximity of MFs to mandibular teeth. The position and shape of MFs were measured and calculated. The Pythagorean theorem was used to calculate the distance between the root apex of the mandibular teeth and the MF. Results MFs exhibited a predominantly round shape (left: 67% and right: 65%) followed by oval (left: 30% and right: 31%) in both males and females and in different age groups. The root apices of mandibular second premolars (left: 71% and right: 62%) were closest to the MF, followed by distal to the first premolars and mesial to the second premolars. The mean vertical distance between the MF and the nearest tooth apex calculated on sagittal sections was 2.20 mm on the right side and 2.32 mm on the left side; no significant difference was found according to sex or age. The distance between the apices of the teeth and the MF was ≥ 4 mm (left; 4.09 ± 1.27 mm and right; 4.01 ± 1.15 mm). Conclusions These findings highlight the need for clinicians to be aware of the location of the MF in treatment planning and while performing non-surgical and surgical endodontic procedures.
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Formulation and development of embelin liquisolid systems using quality by design approach
Komal Parmar,Jayvadan Patel,Navin Sheth 한국약제학회 2016 Journal of Pharmaceutical Investigation Vol.46 No.6
The purpose of the present investigation was to improve dissolution properties of poorly water soluble herbal active ingredient, Embelin (EMB) by formulating liquisolid systems. The new mathematical model was employed for the preparation of the liquisolid systems. Drug loaded liquisolid systems were optimized by utilizing design of experiments (DoE) and principal component analysis (PCA) with carrier-coating ratio (X1) and drug concentration in liquid (X2) as factors. Angle of repose and percentage drug release in 30 min were selected as dependent variables. The liquisolid systems were prepared using Solutol HS-15 in combination of Synperonic PE/ L61 in ratio of 1:1 as non-volatile liquid, Neusilin US2 as carrier and Aerosil 200 as coating material. The relationship between dependent and independent variables were further explicated through regression analysis and response surface plots. Prepared systems were characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry and powder X-ray diffraction studies. Invitro dissolution results revealed significant enhancement in drug release properties from the formulations. Physicochemical characterization of liquisolid systems proposed reduction in drug crystallinity which might be ascribed for improvement in dissolution properties. Study demonstrated successful utilization of Solutol HS-15 in combination of Synperonic PE/L61 for dissolution enhancement of EMB.
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Fabrication and characterization of liquisolid compacts of Embelin for dissolution enhancement
Komal Parmar,Jayvadan Patel,Navin Sheth 한국약제학회 2014 Journal of Pharmaceutical Investigation Vol.44 No.5
In the present investigation, an attempt wasmade to improve the dissolution properties of waterinsoluble herbal active ingredient, Embelin (EBN) by utilizingliquisolid technique, which might offer improvedbioavailability. The compacts were prepared using Capryol90 as non-volatile solvent, Neusilin as carrier and Aerosil200 as coating material. Mathematical model and 32 factorialdesign with liquid load factor (X1) and drug concentration(X2) as the independent variables, was utilizedto prepare the liquisolid powder systems. The preparedsystems were subjected for studying micromeritic propertiesand possible drug-excipient interactions by fouriertransform infrared spectroscopy (FTIR), differential scanningcalorimetry (DSC) and powder X-ray diffraction(PXRD). Dissolution studies revealed improvement in thedrug release properties. Physicochemical characterizationof liquisolid compacts by FTIR, DSC and PXRD techniquessuggested reduction in drug crystallinity elaboratingfor the dissolution enhancement. The study reveals thatliquisolid technique is a promising alternative for enhancingdissolution characteristics of EBN.
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