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RISS 인기검색어
- 검색키워드
- 저자 : Shaobo Zhou (검색결과 5 건)
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Zhou, Tao,Wang, Fuyu,Meng, Xianghui,Ba, Jianmin,Wei, Shaobo,Xu, Bainan The Korean Neurosurgical Society 2014 Journal of Korean neurosurgical society Vol.56 No.5
Objective : To determine the efficacy of endoscopic surgery in combination with long-acting somatostatin analogues (SSAs) in treating patients with growth hormone (GH)-secreting pituitary tumor. Methods : We performed retrospective analysis of 133 patients with GH producing pituitary adenoma who underwent pure endoscopic transsphenoidal surgery in our center from January 2007 to July 2012. Patients were followed up for a range of 3-48 months. The radiological remission, biochemical remission and complication were evaluated. Results : A total of 110 (82.7%) patients achieved radiological complete resection, 11 (8.2%) subtotal resection, and 12 (9.0%) partial resection. Eighty-eight (66.2%) patients showed nadir GH level less than 1 ng/mL after oral glucose administration. No mortality or severe disability was observed during follow up. Preoperative long-acting SSA successfully improved left ventricle ejection fraction (LVEF) and blood glucose in three patients who subsequently underwent success operation. Long-acting SSA (20 mg every 30 days) achieved biochemical remission in 19 out 23 (82.6%) patients who showed persistent high GH level after surgery. Conclusion : Endoscopic transsphenoidal surgery can biochemically cure the majority of GH producing pituitary adenoma. Post-operative use of SSA can improve biochemical remission.
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Huili Wang,Shaobo Zhou,Yan Zhang,Sifeng Qin 한국강구조학회 2023 International Journal of Steel Structures Vol.23 No.6
Tensile-plate anchorage (TPA) is widely used in steel cable-stayed bridges. However, due to the complex geometry of the anchorage, the stress concentration area will appear under the action of the dynamic load, leading to fatigue failure. In this paper, taking a cable-stayed bridge as an example, the theoretical analysis and experimental investigation of the fatigue performance of TPA are performed. At first, a full-bridge finite element model was set up to obtain the severest cable force and cable force amplitude under fatigue load. Then the fatigue test of 1:1.5 specimen was carried out. The maximum principal stress of TPA was 32.24 MPa and the maximum deformation was 1.6 mm. During the loading process, TPA was in elastic working state. After 2 million fatigue load cycles, no cracks were found. At last, the fatigue performance of TPA was analyzed with the theory of critical distances (TCD). The results of the theoretical analysis and fatigue test show that the fatigue performance of TPA could satisfy the use requirement.
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The “living” Feature of the ATRP Macroinitiators in Different Catalytic Systems
Yazhen Wang,Li Liu,Shaobo Dong,Xilai Zhou,Chenglong Wang,Zhen Shi 대한금속·재료학회 2021 ELECTRONIC MATERIALS LETTERS Vol.17 No.2
Atom transfer radical polymerization (ATRP) has achieved widespread use in living polymerization. However, until now there hasbeen little report that macroinitiators initiate polymerization in different catalytic systems. The preparation of bromine-terminatedpolymethyl methacrylate (PMMA-Br) and chlorine-terminated PMMA (PMMA-Cl) were carried out via reverse atom transferradical polymerization (RATRP). The PMMA with halogen termination and narrow polydispersity (Mn = 12,000–15,000 g/mol,Mw/Mn = 1.1–1.2) were used as macroinitiators. The block copolymer of polymethyl methacrylate and polyacrylonitrile (PMMAb-PAN) was prepared in different catalytic systems through normal ATRP. The analyses of the 1H NMR showed that the PMMAprepared by RATRP were end-functionalized by halogen atoms, demonstrated the activities of the PMMA macroinitiators. Themolecular weight and polydispersity index (PDI) of the polymers were analyzed using gel permeation chromatography (GPC). The results indicated that the block polymers that the molecular weight of the block copolymer after chain extension has increasedsignificantly and the molecular weight distribution is narrow (Mn = 17,000–25,000 g/mol, Mw/Mn = 1.1–1.3). The kinetics ofthese polymerization processes were studied as a function of monomers to the macroinitiator molar ratio. It was found that thepolymerizations in different catalytic systems coincidence first-order kinetics with respect to monomers.
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Antitumor and Apoptosis Induction Effects of Paeonol on Mice Bearing EMT6 Breast Carcinoma
( Yetao Ou ),( Qingwang Li ),( Jianjie Wang ),( Kun Li ),( Shaobo Zhou ) 한국응용약물학회 2014 Biomolecules & Therapeutics(구 응용약물학회지) Vol.22 No.4
Paeonol is a major phenolic micromolecular component of Moutan cortex Radicis, a traditional Chinese Medicine. It has shown antitumor effects in previous studies; however, the underlying mechanisms remain unknown. This study investigated the mechanism by giving treatments of placebo, cyclophosphamide, paeonol of 150 and 300 mg/kg to 4 groups of mice bearing EMT6 breast cancer. Apoptosis in tumor cells were confi rmed by morphology analysis, including hematoxylin, eosin staining and TUNEL staining. The results showed that the weight of EMT6 breast tumor was signifi cantly reduced in the groups treated with both 150 and 300 mg/kg of paeonol. Immunohistochemical and Western blot results showed that the expression of Bcl-2 was down-regulated while the expression of Bax, caspase 8 and caspase 3 was up-regulated respectively. These results suggest that paeonol exhibits antitumor effects and the mechanism of the inhibition is via induction of apoptosis, regulation of Bcl-2 and Bax expression, and activation of caspase 8 and caspase 3.
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Jianjie Wang,Qingwang Li,Yetao Ou,Zengsheng Han,Kun Li,Peijun Wang,Shaobo Zhou 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.6
Human lactoferrin (hLTF), an 80-kDa iron-binding glycoprotein, has antitumor activity. In this study, a recombinant adenovirus containing the human lactoferrin cDNA (ad-rhLTF) was constructed and its effect on tumor growth was investigated in mice bearing EMT6 breast cancer. Ad-rhLTF was injected seven times within 14 days into the tumor site at two concentrations (10^8 and 5 × 10^8 pfu/mL) in mice bearing EMT6 breast cancer. Injected ad-rhLTF had considerable cytotoxicity on mice breast cancer, and significantly reducing the weight of tumor produced and increasing the tumor inhibition rate up to 52.64%. The presence of apoptotic cells was confirmed using TUNEL staining and flow cytometry assays. At the same time, RTPCR and Western blot analyses demonstrated that ad-rhLTF also decreased expression of Bcl-2 and increased Bax and caspase 3 expressions. Therefore, we conclude that ad-rhLTF inhibits tumor growth by inducing tumor cell apoptosis in mice with breast cancer by triggering the mitochondrial-dependent pathway and activation of caspase 3. The results indicate that adrhLTF might be a promising drug for breast cancer gene therapy.
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