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      • The Roles of Personal Innovation and Task Technology Fit in Mobile Payment Retention

        Laddawan Kaewkitipong(Laddawan Kaewkitipong ),Charlie Chen(Charlie Chen),Shanshan Lou(Shanshan Lou) The International Academy of Global Business and T 2023 The International Academy of Global Business and T Vol.19 No.2

        Purpose - This research aims to investigate the continuance intention of mobile payment services in Thailand based on the perceived innovativeness (PI) and task-technology fit (TTF) theories. The high attrition rate of mobile payment services in the market and lack of studies exploring the effect of personal attributes on continuance intention motivate the research. Design/Methodology/Approach - 544 Thai mobile payment users were surveyed. Relationships between mobile technology skills, perceived usefulness of mobile payment services, perceived ease of use, PI, TTF, and continuance intention were analyzed using structural equation modeling (SEM). Findings - The results indicate that perceived usefulness is the primary antecedent for TTF. Both TTF and PI were also found to have a significantly positive effect on the increase of continuance intention to use mobile payment services. Moreover, PI was found to have a strong negative moderating effect on the relationship between perceived task-technology fit and the continuance intention of using mobile payment services. Research Implications - The findings provide important insights for mobile payment service providers on how to effectively target users and increase the intention to continue using mobile payment services.

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        1-Oxoeudesm-11(13)-ene-12,8α-lactone-induced Apoptosis via ROS Generation and Mitochondria Activation in MCF-7 Cells

        Min Cui,Xia Li,Yahong Zhang,Shanshan Liu,Weidong Xie,Mei Ji,Hongxiang Lou 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.8

        A novel eudesmane-type sesquiterpene compound, 1-oxoeudesm-11(13)-eno-12,8a-lactone (OEL), was isolated from Aster himalaicus. Its effect on apoptosis in human breast adenocarcinoma (MCF-7) cells was investigated. MTT assay showed that OEL substantially reduced the viability of KB, MCF-7, U87, A172, and MG-63 cells. MCF-7 cells were used to further evaluate the antitumor effects and anticancer mechanisms of OEL. OEL-induced apoptosis was characterized by chromatin condensation, formation of apoptotic bodies, and phosphatidylserine on extracellular surface; these effects were confirmed by DAPI nuclear staining and flow cytometry. Increased expression of Bax and deceased expression of Bcl-2 were also observed in OELtreated MCF-7 cells. Moreover, OEL induced the loss of mitochondria membrane potential, release of cytochrome C, activation of caspase-9, and generation of reactive oxygen species. These findings indicate that reactive oxygen species generation and mitochondria activation were involved in apoptosis induced by OEL in MCF-7 cells. The results from our study demonstrated that OEL may be a promising pro-apoptotic compound that could be used to develop novel anticancer drugs.

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