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Saravanabhavan, Shanmuga Sundar,Rethinasabapathy, Muruganantham,Zsolt, Sarang,Kalambettu, Aravind Bhat,Elumalai, Sundaravadivel,Janakiraman, Manokaran,Huh, Yun Suk,Natesan, Balasubramanian Elsevier 2019 Materials science & engineering. C, Materials for Vol.99 No.-
<P><B>Abstract</B></P> <P>Presently, quite a lot of research that are being carried out to find a potential cure for cancer and many had made to clinical trial stage as well. In the present study, we focus on use of a novel graphene oxide functionalized chitosan nanoparticle targeting Saos-2 and MG-63 osteosarcoma cells. The graphene oxide chitosan nanoparticles were loaded with siRNA, studied for <I>in vitro</I> release with varying concentration & pH, and fitted to peppas model. MTT & ROS assay was used to evaluate biocompatibility of carrier and qPCR to study the inflammatory responses in particular checking gene expression of IL-6, TGF-ß, TNF-α in both RAW 264.7 and bone marrow derived macrophages. The results of study showed that release of siRNA were in a controlled fashion and effective at acidic pH that prevails on tumor site. The material was biocompatible and effective in case of Saos-2 osteosarcoma cells with a viability of 0.4 ± 0.43 and 0.49 ± 0.53 in case of MG-63 cells when treated with highest concentration of 100 μl siRNA compared to untreated cells that were in range of 0.64 ± 0.67 in Saos-2 and 0.61 ± 0.63 in MG-63 cells. The results of expression of inflammatory cytokines IL-6, TGF-β & TNF-α showed negligible amount compared to control group serving the purpose of an effective carrier targeting tumor cells.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Graphene oxide functionalized chitosan nanoparticle with siRNA targeting <I>Saos-2</I> and <I>MG-63</I> cells exhibited a controlled release. </LI> <LI> Effective release of siRNA on cancer cells and destruction of the same. </LI> <LI> No inflammation observed when treated with RAW and Bone Marrow derived macrophages derived from mice models. </LI> <LI> Inflammatory response was less compared to the control groups and under testing <I>in vivo</I> on mice models </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
A study on novel coupled membrane bioreactor with electro oxidation for biofouling reduction
Kamalakannan Vasanthapalaniapp,Kavitha Palani,Shanmuga Sundar Saravanabhavan,Narendranath Jonna,Maharaja Pounsamy,Kannan Natarajan,Yun Suk Huh,Balasubramanian Natesan 대한환경공학회 2021 Environmental Engineering Research Vol.26 No.4
Lead is the most globally bountiful harmful substantial component in nature. Its utilization can be followed to verifiable occasions. The current work archives the combination, portrayal, and utilization of bentonite/chitosan/NiFe₂O₄ ternary novel nanocomposite. Nanostructured nickel ferrite was joined with chitosan and bentonite to frame a novel ternary nanocomposite. The nanocomposite was portrayed by FT-IR, powder XRD, VSM, and TEM investigation. All the logical outcomes affirm the fruitful arrangement of ternary composite. The as-blended nanomaterial was applied as nanoadsorbent for the evacuation of lead (II) from water. The ideal composite portion was 50㎎/100㎖ was seen as profoundly powerful for the evacuation of 82% Pb (II) particles from 200 ppm watery arrangement. This ferromagnetic, minimal effort, the eco-accommodating nanocomposite may end up being helpful for the expulsion of lead from watery arrangement at the mechanical level.
Kavitha Nagarasampatti Palani,Darshini Saravanan,Kamalakannan Vasantha Palaniappan,Shanmuga Sundar,N Balasubramanian 한국화학공학회 2019 Korean Journal of Chemical Engineering Vol.36 No.2
The present study focuses on overcoming the drawback as fouling in a membrane bioreactor (MBR), which can be alleviated by integrating advanced oxidation process, adsorption, and biofilm carriers in the activated sludge process. The optimal sludge retention time, carbon and ozone dosage was 150 minutes, 15 g and 1.5 Lmin−1, respectively. The percentage removal was observed to be above 90% for chemical oxygen demand and total organic carbon whereas for total dissolved solids was only 40% under transmembrane pressure of 20 kPa. The increase in permeate flux was 30% as compared to MBR. Sequential batch membrane bioreactor (SBMBR) showed 12% reduction in energy consumption for three hour operation at the flow rate of 0.72 L/h (transmembrane pressure 20 kPa), and it was confirmed in the SEM of carbon, membrane, UV, CV and HPLC also. The energy consumption required also confirms the less internal fouling via the extended backwash of four hours.