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68Ga‑DOTANOC PET/CT for Screening and Surveillance of Von Hippel‑Lindau (VHL) disease
Shamim Ahmed Shamim,Geetanjali Arora,Naresh Kumar,Jhangir Hussain,Shreya Datta Gupta,Arun Raj ST,Kritin Shankar,Alpesh Goyal,Rajesh Khadgawat,Sambit Sagar,Chandrasekhar Bal 대한핵의학회 2023 핵의학 분자영상 Vol.57 No.5
Purpose Hereditary tumor syndrome Von Hippel-Lindau (VHL) disease is characterized by various benign and malignanttumors that are known to express somatostatin receptors (SSTR). We evaluated the role of 68Ga-DOTANOC PET/CT scan inpatients with positive germline mutation of the VHL gene, presented initially or on follow-up, for the detection of recurrentor synchronous/metachronous lesions. Methods Fourteen patients (8 males; 6 females) with mean age 30 ± 9.86 years were retrospectively analyzed, were testedpositive for VHL on gene dosage analysis, and underwent 68 Ga-DOTANOC PET/CT scan for disease evaluation. The numberand site of lesions were determined. The tracer uptake was analyzed semi-quantitatively by calculating the maximumstandardized uptake values (SUVmax) of lesion. Results Four of the 14 patients underwent scan for initial diagnosis as baseline, 6 patients for post-therapy disease status,and 4 patients for initial diagnosis as well as follow-up evaluation of the disease. A total of 67 lesions were detected in 14patients. The sites of lesions were cerebellar/vertebral/spinal (17; mean SUVmax = 7.85); pancreatic neuroendocrine tumor(NET) (11; mean SUVmax = 20.64); retina (3; mean SUVmax = 10.46); pheochromocytoma (10; mean SUVmax = 16.32);paragangliomas (3; mean SUVmax = 10.65); pancreatic cyst (9; mean SUVmax = 2.54); and renal cyst (8; mean SUVmax= 1.56) and miscellaneous lesions constituted 6 lesions. Conclusion Our results show that 68 Ga-DOTANOC PET/CT may be a useful modality for screening and follow-up of associatedtumors in patients with germline gene mutation for VHL. It can be used as a one-stop imaging modality for VHL patientsand may substitute for separate radiological investigations, making it more convenient for patients in terms of time and cost.
Jwariya Shamim(Jwariya Shamim ),Athar Parvez Ansari(Athar Parvez Ansari ),Pankaj Goswami(Pankaj Goswami ),Seema Akbar(Seema Akbar ),Huzaifa Ansari(Huzaifa Ansari ),Abdul Wadud(Abdul Wadud ),Pervaiz Ah 셀메드 세포교정의약학회 2023 셀메드 (CellMed) Vol.13 No.6
Objectives:Cassia occidentalis L. is a weed belonging to the Caesalpiniaceae family. The root of this medicinal plant is used for the treatment of various ailments, including kidney diseases. The present study was aimed at evaluating the nephroprotective effects of HAE of the roots of Cassia occidentalis L. against gentamicin-induced renal toxicity in albino Wistar rats. Methods:The renal toxicity was induced by subcutaneous administration of gentamicin at 100 mg/kg in the rats belonging to the disease control and treatment groups from the 4th to the 8th day. The rats in the treatment group received HAE of the roots of Cassia occidentalis L. at 67 mg/kg b. w. orally for 8 days, while no treatment was given to the rats in the disease control and plain control groups. At the end of the experiment, renal biomarkers viz; s. creatinine, b. urea, and s. uric acid, were investigated. The histopathological examination of the kidney specimens was also carried out. Results:The results of the present study revealed that renal function biomarkers such as s. creatinine, b. urea, and s. uric acid were significantly reduced in the rats of the treatment group as compared to those of the disease control group. Moreover, the histoarchitecture reports of the treatment group’s kidney specimens showed significant improvements. Conclusion:The results suggested that the HAE of Cassia occidentalis L. roots promisingly prevented kidney injury in gentamicin-induced nephrotoxic rats. This effect might be due to improved clearance of gentamicin from the renal tubule and decreased generation of reactive oxygen species (ROS).
SELF-DETERMINED MOTIVATION, MINDFULNESS, AND GREEN CONSUMPTION BEHAVIOR
Shamim Ahmed Khan,Soo Yeong Ewe,Md. Yunus Ali,Motoki Watabe 글로벌지식마케팅경영학회 2023 Global Marketing Conference Vol.2023 No.07
Green consumption behavior (GCB) is desirable for a better world. The trend of GCB is expected to rise in the coming years. As such, it is imperative to understand the enablers of GCB. A significant majority of the investigated drivers of GCB are consumer-level factors. Studies focusing on the consumer-level showed that factors such as values, intentions, and personal norms could influence GCB. However, it is argued that compared to values or intentions, self-determined motivation can better predict GCB. The effect of self-determined motivation types (i.e., autonomous and controlled motivation) on GCB remains unclear due to prevailing gaps and contradictory findings. Furthermore, it is posited that people exhibit more self-determined behavior if they have strong self-awareness. Higher self-awareness can be achieved through mindfulness; therefore, differences in mindfulness level could affect the motivation-behavior relationship.
Occurrence and identification of Emeria species in broiler rearing under traditional system
Shamim, Asim,Hassan, Murtaz ul,Yousaf, Arfan,Iqbal, Muhammad Farooq,Zafar, Muhammad Arif,Siddique, Rao Muhammad,Abubakar, Muhammad Korean Society of Animal Sciences and Technology 2015 한국축산학회지 Vol.57 No.12
Background: The present study was intended to determine the prevalence and identification of species involved causing coccidiosis in broilers rearing under traditional farming system in Mirpur, Azad Kashmir, Pakistan. For the current study, a convenient sampling technique was carried out. A total of 7814 broilers (aged 1 to 6 weeks) were submitted to the Disease Diagnostic Laboratory of Livestock and Animal husbandry Department Mirpur, Azad Kashmir. Results: From the total screened, 750 were found positive for coccidiosis representing an overall prevalence of 9.59 %. Age-wise highest prevalence (10.88 %) recorded in the middle age birds (0 to 3 week old) were found more susceptible to infection than those aged above 3 weeks. Higher prevalence (12.49 %) of coccidiosis in broilers was observed in spring as compared with 6.60 % in summer season. In this study two main coccidiosis causing species, Emeria tenella and Emeria maxima were identified on the basis of their morphological feature and habitat (caeca and intestine), However, E. tenella was dominant compared to E. maxima. Conclusion: The study provides an insight to the occurrence of Emeria species which must be taken into consideration when rearing the broilers.
Application of Geospatial Technology for the Promotion of Tourist Industry in Srinagar City
Shamim Ahmad Shah,Muzafar Ahmad Wani 보안공학연구지원센터(IJUNESST) 2015 International Journal of u- and e- Service, Scienc Vol.8 No.1
Tourism is a relaxation place for people and people can plan their tourist places based on Information. GIS -based information is gaining greater importance among tourists as it allows to familiarize with places, have profound appeal for the trip planning. Srinagar city is famous tourist destination of India, visited by huge number of tourists from different parts of the world annually. The number of tourists visited the city in 1990 was 10623 which increased to 112012 in 2000 and in year 2013 more than 13 lakh, the number can be dramatically increased, given the nature of tourism potential of the city. But in the absence of Tourist Information System, tourists face various difficulties in locating various tourist related products. The Geospatial technology has transformed every sphere of life and tourism industry cannot be exception. The purpose of the present study is to develop an interactive and user-friendly Geographic Information System (GIS) enabled data base for various amenities viz. hotels, guest houses, house boats, road networks, airport, railway station, parks, shrines, play grounds, golf course, water bodies etc. in ESRI’s ArcGIS 10.1 software which could be easily uploaded on web to disseminate proper information to world over. Toposheets, maps satellite images, GPS and field surveys were used to generate the above mentioned data layers and then multimedia data like video clips, audio narrations and photographs were integrated with each feature to make comprehensive tourist information system. A major strength of this paper is that TIS is one time investment and can be updated as and when needed. It provides tools to display raw data in the form of 3D maps, SQL, understand Patterns, relationships and trends and overlay those databases in highly interactive ways which is not possible with traditional spreadsheets. The present study actively demonstrated the potential of geospatial technology application to explore destination and its facilities like hospitals, ATM Centers, hotels, restaurants, resorts and filling stations etc. and developmental planning, project monitoring and publicity of tourist products. The present study can be indispensable for other allied departments’ viz police, planning, public administration, disaster management, transportation, health etc.
Shamim-Ara Pervin,김갑진,Arun Anand Prabu,이용택 한국고분자학회 2015 Macromolecular Research Vol.23 No.1
Poly(vinylidene fluoride) (PVDF) based water purification membranes exhibit excellent thermal stability andchemical resistance, but also possess inherent drawbacks such as severe membrane fouling, lower separation efficiency andwater flux due to its hydrophobic nature. In the present study, we attempted to enhance the hydrophilicity of PVDFmembranes by treating with varying content (0 to 3 wt%) of partially sulfonated poly(1,4-phenylene sulfide) (sPPS)component using phase-inversion process. Compared to neat PVDF membrane, the PVDF/sPPS blend membranesexhibited typical asymmetric morphology with larger finger-like pores, efficient distribution of hydrophilic SO3-groups and decreasing water contact angle (WCA) upto 62o (77o for neat PVDF) as confirmed from scanning electronmicroscope (SEM), energy dispersive X-ray spectroscopy (EDX) and contact-angle measurements, respectively. Studies carried out for pure water flux (880 L/m2h) and blood serum albumin (BSA) solution flux (185 L/m2h)confirmed the enhanced permeability and higher fouling resistance for PVDF-sPPS (3 wt% sPPS) membranescompared to neat PVDF membrane (175 L/m2h and 63 L/m2h, respectively), though the BSA flux decreased withan increase in the filtration time due to membrane fouling. Compared to the total organic carbon (TOC) values ofpoly(ethylene oxide) (PEO) aqueous solutions before permeation (189.9 mg/L for Mw=100,000 and 75.68 mg/L forMw=300,000), TOC of neat PVDF membrane decreased to 15 mg/L for Mw= 100,000 and 5 mg/L for Mw=300,000. Withincreasing sPPS content, the TOC values showed an increasing trend due to their increasing pore size. Overall, theincorporation of sPPS in PVDF membrane lowered the WCA, enhanced fouling resistance and improved its permeabilityand selectivity, which exemplifies the importance of this study.