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A New Method for Refining3D Protein Predicted Models Based on 3D Random Walk
Shaheera Rashwan,Bayumy A. B. Youssef 보안공학연구지원센터 2016 International Journal of Bio-Science and Bio-Techn Vol.8 No.1
Predicting protein 3D structures from the amino acid sequence is still a hard and unsolved task after five decades of efforts. High-resolution models can be built only if the target protein has a known homologue. If not, it must be built from scratch which yields in most cases to protein models of low-resolution, i.e. far from their native structure. In this paper, we present a new refinement method of 3D protein predicted models. The new method relies on the motion that the atoms in a protein take randomly in the 3D space leading to folding. Experimental results using the CASP benchmark show the assessment and the quality of the new method in comparison with the traditional methods that depend on molecular dynamics simulation.We prove that 55 % of cases were successfully enhanced by the new method.
A survey on retention practice among orthodontists in Malaysia
Norma Ab Rahman,Tze Fui Low,Nur Shaheera Idris 대한치과교정학회 2016 대한치과교정학회지 Vol.46 No.1
Objective: The aim of this study was to evaluate retention practices commonly employed by orthodontists. The objectives were to identify the types of retainer frequently used and to investigate the variations in retention practice. Methods: A total of 97 orthodontists were randomly selected, and a questionnaire consisting of 25 multiple-choice questions sent to them by mail. Upon receiving of the completed questionnaires, the data were statistically analyzed. Results: A total of 32 responses were received; among these, 59.4% of orthodontists’ practiced is in a government setting and 40.6% were in private practice. A vacuum-formed retainer was the most commonly used removable retainer for both maxillary (46.9%) and mandibular (46.9%) arches, followed by a Hawley retainer (maxilla, 43.8%; mandible, 37.5%), and a fixed retainer (maxilla, 3.1%; mandible, 9.4%). Of the responding orthodontists, 78.1% prescribed full-time wear (more than 20 h per day) for a duration of 3−9 months for a maxillary arch, compared to 71.9% for the mandibular arch. Only 18.8% of the orthodontists prescribed part-time wear of the retainer for the maxillary arch, compared to 21.9% for the mandibular arch. The majority of orthodontists did not instruct their patients to stop wearing removable retainers (71.9%) or fixed retainers (66.8%) at any specific time and they preferred their patients to continue wearing retainers. Conclusions: Vacuum-formed retainers are the most commonly used retainers among orthodontists. The majority of orthodontists prescribed full-time wear for more than 20 h per day with a duration of 3−9 months and preferred indefinite use of the retainer.
Valliani, Arif,Ahmed, Bilawal,Nanji, Kashmira,Valliani, Salimah,Zulfiqar, Beenish,Fakih, Misbah,Mehdi, Mehwish,Khan, Anam,Sheikh, Sana Arshad,Fatima, Nida,Ahmad, Sobia,Farah, Fariya,Saleem, Shaheera,A Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5
Background: Use of smoke-less tobacco (SLT) is very common in South and South-East Asian countries. It is significantly associated with various types of cancers. The objectives of this study were to assess the proportion of hospital staff that use SLT, and to identify the factors associated with its use and their practices. Methods: In a cross-sectional study, 560 staff of two tertiary care hospitals were interviewed in the year 2009. Nurses, ward boys and technicians were counted as a paramedic staff while drivers, peons, security guards and housekeeping staff were labeled as non-paramedic staff. SLT use was considered as usage of any of the following: betel quid (paan) with or without tobacco, betel nuts with or without tobacco (gutkha) and snuff (naswar). Results: About half (48.6%) of the hospital staff were using at least one type of SLT. Factors found to be statistically significant with SLT were being a male (OR=2.5; 95% CI=1.8-3.7); having no/fewer years of education (OR=1.7; 95% CI=1.2-2.4) and working as non-paramedic staff (OR=2.6; 95% CI=1.8-3.8). Majority of SLT users were using it on regular basis, for > 5 years and keeping the tobacco products in the oral cavity for >30 minutes. About half of the users started due to peer pressure and had tried to quit this habit but failed. Conclusion: In this study, about half of the study participants were using SLT in different forms. We suggest educational and behavioral interventions for control of SLT usage.