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Hypotensive and Toxicological Study of Citric Acid and Other Constituents from Tagetes patula Roots
Saleem, Rubeena,Ahmad, Mohammad,Naz, Aneela,Siddiqui, Humaira,Ahmad, Syed Iqbal,Faizi , Shaheen The Pharmaceutical Society of Korea 2004 Archives of Pharmacal Research Vol.27 No.10
Study of the effects of the methanolic extract of Tagetes patula roots on blood pressure led to the isolation of well known citric (1) and malic acid (7) as hypotensive, and pyridine hydrochloride (4) as hypertensive constituents of the plant along with a new constituent, 2-hydroxy, 5- hydroxymethyl furan (9). Citric acid and malic acid caused 71% and 43% fall in Mean Arterial Blood Pressure (MABP) of rats at the doses of 15 mg/kg and 30mg/kg respectively while pyridine hydrochloride produced 34% rise in the MABP of rats at the dose of 30mg/kg. $LD_{50}\;and\;LD_{100}$ of citric acid in mice have been determined as 545 mg/kg and 1000 mg/kg, respectively.
Antibacterial activity of flower of Melia azedarach Linn. and identification of its metabolites
Munira Taj Muhammad,Lubna,Nida Fayyaz,Saima Tauseef,Ummarah Razaq,Muhammad Ali Versiani,Aqeel Ahmad,Shaheen Faizi,Munawwer Rasheed 한국응용생명화학회 2015 Applied Biological Chemistry (Appl Biol Chem) Vol.58 No.2
Constituents of eight different extracts and fractions, obtained from flowers of Melia azedarach, were identified by gas chromatography–mass spectrometry and mass spectral library search. Altogether, 38 phytochemicals were identified, all for the first time from the flowers. Only 14 of these were known from parts of M. azedarach other than flowers, while 24 are reported for the first time from any part of the plant. These metabolites included branched and n-hydrocarbons, aromatics, a polyisoprenoid, fatty acids, fatty acid methyl esters, and fatty alcohols, which were found to be different from its essential oil constituents. One major constituent 4-hydroxybenzoic acid (4) was not only identified but also isolated as a pure compound from ethyl acetate extract. Extracts, compound 4 and its derivatives gallic acid and methyl gallate were tested for antimicrobial potential. Gallic acid and methyl gallate exhibited antibacterial activity against Staphylococcus saprophyticus. Methyl gallate also showed some activity against Corynebacterium diphtheriae and Corynebacterium. hofmannii. Among the extracts, only methanol extract exhibited activity against Pseudomonas sp. The extracts only inhibited the growth of dermatophytic fungi.
Antibacterial activity of flower of Melia azedarach Linn. and identification of its metabolites
Muhammad, Munira Taj,Lubna, Lubna,Fayyaz, Nida,Tauseef, Saima,Razaq, Ummarah,Versiani, Muhammad Ali,Ahmad, Aqeel,Faizi, Shaheen,Rasheed, Munawwer The Korean Society for Applied Biological Chemistr 2015 Applied Biological Chemistry (Appl Biol Chem) Vol.58 No.2
Constituents of eight different extracts and fractions, obtained from flowers of Melia azedarach, were identified by gas chromatography-mass spectrometry and mass spectral library search. Altogether, 38 phytochemicals were identified, all for the first time from the flowers. Only 14 of these were known from parts of M. azedarach other than flowers, while 24 are reported for the first time from any part of the plant. These metabolites included branched and n-hydrocarbons, aromatics, a polyisoprenoid, fatty acids, fatty acid methyl esters, and fatty alcohols, which were found to be different from its essential oil constituents. One major constituent 4-hydroxybenzoic acid (4) was not only identified but also isolated as a pure compound from ethyl acetate extract. Extracts, compound 4 and its derivatives gallic acid and methyl gallate were tested for antimicrobial potential. Gallic acid and methyl gallate exhibited antibacterial activity against Staphylococcus saprophyticus. Methyl gallate also showed some activity against Corynebacterium diphtheriae and Corynebacterium. hofmannii. Among the extracts, only methanol extract exhibited activity against Pseudomonas sp. The extracts only inhibited the growth of dermatophytic fungi.