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RISS 인기검색어
- 검색키워드
- 저자 : Seyed Jamaleddin Mostafavi Yazdi (검색결과 3 건)
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Seyed Jamaleddin Mostafavi Yazdi,조광수,강남철 한국유변학회 2018 Korea-Australia rheology journal Vol.30 No.4
Characterization of viscoelastic properties of the human thigh skin can be utilized in many medical or engineering applications such as a surgical extension of the thigh skin, a tissue engineering, and a finite element modeling of thigh skin in a sitting posture. This study aims to determine the effective short- and long-term shear moduli of posterior thigh skin using ramp-relaxation test in a sitting posture. The effect of indentation location, the sitting posture, and the applied load (thigh weight) were investigated on the extracted effective shear moduli. We modeled the human skin by using the one- and two-term Prony series, and it was found that the generalized Maxwell model with two-term Prony series agreed well with experimental data. The effective shear moduli (short- and long-term) were extracted by fitting the total reaction force of the generalized Maxwell model to the experimental data using the Levenberg-Marquardt algorithm. The contour maps were used to show the spatial dependency of the effective shear moduli at the flat regions of posterior thigh skin. The contour maps of effective shear moduli show that maximum effective shear moduli locate near buttock’s center, while minimum effective shear moduli locate at the distal and medial posterior thigh. It is also found that the extracted effective short-term shear modulus varies between 3978.2 N/m² and 13699.2 N/m². On the other hand, the extracted effective long-term shear modulus differs between 2715.1 N/m² and 9194.3 N/m² for different sitting postures. Additionally, it is found that the observed increase in effective shear moduli could be attributed to the increase applied load, and leg angle.
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Poly(lactic acid)/poly(lactic‑co‑glycolic acid) particulate carriers for pulmonary drug delivery
Dong Hee Na,Fakhrossadat Emami,Seyed Jamaleddin Mostafavi Yazdi 한국약제학회 2019 Journal of Pharmaceutical Investigation Vol.49 No.4
Background Pulmonary route is an attractive target for both systemic and local drug delivery, with the advantages of a large surface area, rich blood supply, and absence of first-pass metabolism. Numerous polymeric micro/nanoparticles have been designed and studied for controlled and targeted drug delivery to the lung. Area covered Among the natural and synthetic polymers for polymeric particles, poly(lactic acid) (PLA) and poly(lacticco- glycolic acid) (PLGA) have been widely used for the delivery of anti-cancer agents, anti-inflammatory drugs, vaccines, peptides, and proteins because of their highly biocompatible and biodegradable properties. This review focuses on the characteristics of PLA/PLGA particles as carriers of drugs for efficient delivery to the lung. Furthermore, the manufacturing techniques of the polymeric particles, and their applications for inhalation therapy were discussed. Expert opinion Compared to other carriers including liposomes, PLA/PLGA particles present a high structural integrity providing enhanced stability, higher drug loading, and prolonged drug release. Adequately designed and engineered polymeric particles can contribute to a desirable pulmonary drug delivery characterized by a sustained drug release, prolonged drug action, reduction in the therapeutic dose, and improved patient compliance.
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Emami Fakhrossadat,Keihan Shokooh Mahsa,Mostafavi Yazdi Seyed Jamaleddin 한국약제학회 2023 Journal of Pharmaceutical Investigation Vol.53 No.1
Background Most biopharmaceuticals are developed in liquid dosage forms that are less stable than solid forms. To ensure the stability of biopharmaceuticals, it is critical to use an effective drying technique in the presence of an appropriate stabilizing excipient. Various drying techniques are available for this purpose, such as freeze drying or lyophilization, spray drying, spray freeze-drying, supercritical fluid drying, particle replication in nonwetting templates, and fluidized bed drying. Area covered In this review, we discuss drying technologies and their applications in the production of stable solid-state biopharmaceuticals, providing examples of commercially available products or clinical trial formulations. Alongside this, we also review how different analytical methods may be utilized in the evaluation of aerosol performance and powder characteristics of dried protein powders. Finally, we assess the protein integrity in terms of conformational and physicochemical stability and biological activity. Expert opinion With the aim of treating either infectious respiratory diseases or systemic disorders, inhaled biopharmaceuticals reduce both therapeutic dose and cost of therapy. Drying methods in the presence of optimized protein/stabilizer combinations, produce solid dosage forms of proteins with greater stability. A suitable drying method was chosen, and the process parameters were optimized based on the route of protein administration. With the ongoing trend of addressing deficiencies in biopharmaceutical production, developing new methods to replace conventional drying methods, and investigating novel excipients for more efficient stabilizing effects, these products have the potential to dominate the pharmaceutical industry in the future.
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