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Atypical necrotizing encephalitis associated with systemic canine distemper virus infection in pups
Alexandre Mendes Amude,Selwyn Arlington Headley,Amauri Alcindo Alfieri,Suely Nunes Esteves Beloni,Alice Fernandes Alfieri 대한수의학회 2011 JOURNAL OF VETERINARY SCIENCE Vol.12 No.4
This report describes the naturally occurring atypical neuropathological manifestation of systemic canine distemper virus (CDV) infection in two 16-day-old Pit Bull pups. CDV-induced changes affected the gray and white matter of the forebrain while sparing the hindbrain. Histologically, there was necrosis with destruction of the nervous parenchyma due to an influx of inflammatory and reactive cells associated with eosinophilic intranuclear inclusion bodies within glial cells. Positive immunoreactivity against CDV antigens was predominantly observed within astrocytes and neurons. RT-PCR was used to amplify CDV-specific amplicons from brain fragments. These findings suggest the participation of CDV in the etiopathogenesis of these lesions.