Drug adsorption and anti-microbial activity of functionalized multiwalled carbon nanotubes

Saxena, Megha,Mittal, Disha,Boudh, Richa,Kumar, Kapinder,Verma, Anita K.,Saxena, Reena Techno-Press 2021 Advances in nano research Vol.11 No.6

Multiwalled carbon nanotubes (MWCNTs) were first oxidized (O-CNTs) to introduce carboxylic group and then further functionalized (F-CNTs) with m-phenylenediamine, which was confirmed by FTIR and SEM. It was used as an effective adsorbent for the adsorptive removal of diclofenac drug from water. Under optimum conditions of pH 6, stirring speed 600 rpm, the maximum adsorption capacity obtained was 532 mg g^-1 which is superior to the values reported in literature. The adsorption was quite rapid as 25 mg L^-1 drug solution was adsorbed in only 3 minutes of contact time with 10 mg of adsorbent dose. The adsorption kinetics and isotherms were studied using various models to evaluate the adsorption process. The results showed that the data best fit in kinetics pseudo-second order and Langmuir isotherm model. Furthermore, the oxidized and functionalized MWCNTs were applied on gram-negative Escherichia coli and gram-positive Staphylococcus aureus using agar disc diffusion assay to validate their anti-microbial activity. Results were unique as both oxidized and functionalized MWCNTs were equally active against both E. coli and S. aureus. The newly synthesized F-CNTs have great potential in water treatment, with their dual action of removing drug and pathogens from water, makes it potential applicant to save environment.

Systematic review of the effectiveness of homoeopathy in the treatment of autism spectrum disorder

Vibha Saxena,Gish Chacko,Udit Saxena 한국언어재활사협회 2021 Clinical Archives of Communication Disorders Vol.6 No.1

Purpose: Over the years there is a significant increase in Autism Spectrum Disorder (ASD), yet there is no standard medical treatment available for this population. Homoeopathy as reported in literature can prove to be a boon for ASD treatment as in homoeopathy patients are prescribed medicine based on specific symptoms in light of associated physical and mental aspect. A systematic review of literature was required to put together the reported information on the relation between homoeopathy and ASD. This work reviews all the related literature in-depth. Methods: Literature on the concerned issue was searched from databases like Scopus, PubMed, ScienceDirect, JASTOR, Google Scholar, PsycINFO (psychology and psychiatry literature), and ERIC (Education Resources Information Center). Results: In total, 19 published articles were found on the investigation of using homoeopathy in the treatment of ASD. Seventeen studies showed that homoeopathy can be effective in the treatment of ASD. Result of 1 study was inconclusive and 1 more study found homoeopathy to be not suitable in treating ASD. Conclusions: Most reports support the use of homoeopathy in the treatment of ASD. They describe that homoeopathy efficiently control ASD symptoms and also supplements other therapies used in the treatment of ASD. Few authors suggested otherwise too.

미동 저항성인자 이용한 육종방향 고려해야$\cdots$ -흰등멸구 Biotypes-

Saxena R.C.,Barrion A.A 한국작물보호협회 1982 자연과 농업 Vol.3 No.11

Efficient 5G Small Cell Planning With eMBMS for Optimal Demand Response in Smart Grids

Saxena, Navrati,Roy, Abhishek,Kim, HanSeok IEEE 2017 IEEE TRANSACTIONS ON INDUSTRIAL INFORMATICS - Vol.13 No.3

<P>Smart Grids (SGs) are emerging cyber-physical systems, equipped with sophisticated communication and information technologies, for efficient and large-scale power supply and management. SGs demand advanced communication technologies between energy providers and consumers, for enabling a control-feedback loop, by using time-dependent pricing. In this paper, we propose an efficient planning of 5G small cells, with evolved multimedia broadcast and multicast communication, between aggregators (small cells) and SG consumers, for efficient demand-response (DR) programs. After pointing out that optimal multicast scheduling and radio resource management problem is NP-complete, we propose two different solutions, based on dynamic programming (DP) and greedy heuristics, for minimizing the energy cost for DR customers. We also analyze the performance of SG user capacity for 5G single cell multicast and multicast broadcast single frequency network. Extensive OPNET simulation results, over actual energy data and real wireless trace, demonstrate that our proposed 5G small cell planning and multicast solutions are capable of reducing energy production cost by 30%, with up to 35% shift in peak energy load, low latency and packet drop.</P>

Active VM Consolidation for Cloud Data Centers under Energy Saving Approach

Saxena, Shailesh,Khan, Mohammad Zubair,Singh, Ravendra,Noorwali, Abdulfattah International Journal of Computer ScienceNetwork S 2021 International journal of computer science and netw Vol.21 No.11

Cloud computing represent a new era of computing that's forms through the combination of service-oriented architecture (SOA), Internet and grid computing with virtualization technology. Virtualization is a concept through which every cloud is enable to provide on-demand services to the users. Most IT service provider adopt cloud based services for their users to meet the high demand of computation, as it is most flexible, reliable and scalable technology. Energy based performance tradeoff become the main challenge in cloud computing, as its acceptance and popularity increases day by day. Cloud data centers required a huge amount of power supply to the virtualization of servers for maintain on- demand high computing. High power demand increase the energy cost of service providers as well as it also harm the environment through the emission of CO₂. An optimization of cloud computing based on energy-performance tradeoff is required to obtain the balance between energy saving and QoS (quality of services) policies of cloud. A study about power usage of resources in cloud data centers based on workload assign to them, says that an idle server consume near about 50% of its peak utilization power [1]. Therefore, more number of underutilized servers in any cloud data center is responsible to reduce the energy performance tradeoff. To handle this issue, a lots of research proposed as energy efficient algorithms for minimize the consumption of energy and also maintain the SLA (service level agreement) at a satisfactory level. VM (virtual machine) consolidation is one such technique that ensured about the balance of energy based SLA. In the scope of this paper, we explore reinforcement with fuzzy logic (RFL) for VM consolidation to achieve energy based SLA. In this proposed RFL based active VM consolidation, the primary objective is to manage physical server (PS) nodes in order to avoid over-utilized and under-utilized, and to optimize the placement of VMs. A dynamic threshold (based on RFL) is proposed for over-utilized PS detection. For over-utilized PS, a VM selection policy based on fuzzy logic is proposed, which selects VM for migration to maintain the balance of SLA. Additionally, it incorporate VM placement policy through categorization of non-overutilized servers as- balanced, under-utilized and critical. CloudSim toolkit is used to simulate the proposed work on real-world work load traces of CoMon Project define by PlanetLab. Simulation results shows that the proposed policies is most energy efficient compared to others in terms of reduction in both electricity usage and SLA violation.

A New Channel-Aware Rate Adaptation in High Speed WLANs

SAXENA, Navrati,ROY, Abhishek The Institute of Electronics, Information and Comm 2009 IEICE TRANSACTIONS ON COMMUNICATIONS - Vol.92 No.6

<P>In this letter we propose an advanced rate adaptation algorithm that intelligently uses the channel statistics to make fast and efficient selection of transmission rates. Our implementation and simulation results prove that the proposed strategy achieves major latency and throughput improvements on 802.11n products and existing related protocols. The entire work is on a software module, thus providing adaptability, cost-effectiveness, with no hardware changes.</P>

Authentication and Authorization Scheme for Various User Roles and Devices in Smart Grid

Saxena, Neetesh,Bong Jun Choi,Rongxing Lu IEEE 2016 IEEE transactions on information forensics and sec Vol.11 No.5

<P>The smart grid, as the next generation of the power grid, is characterized by employing many different types of intelligent devices, such as intelligent electronic devices located at substations, smart meters positioned in the home area network, and outdoor field equipment deployed in the fields. In addition, there are various users in the smart grid network, including customers, operators, maintenance personnel, and so on, who use these devices for various purposes. Therefore, a secure and efficient mutual authentication and authorization scheme is needed in the smart grid to prevent various insider and outsider attacks on many different devices. In this paper, we propose an authentication and authorization scheme for mitigating outsider and insider threats in the smart grid by verifying the user authorization and performing the user authentication together whenever a user accesses the devices. The proposed scheme computes each user role dynamically using an attribute-based access control and verifies the identity of the user together with the device. Security and performance analysis show that the proposed scheme resists various insider as well as outsider attacks, and is more efficient in terms of communication and computation costs in comparison with the existing schemes. The correctness of the proposed scheme is also proved using BAN-Logic and Proverif.</P>

Efficient IoT Gateway over 5G Wireless: A New Design with Prototype and Implementation Results

Saxena, Navrati,Roy, Abhishek,Sahu, Bharat J. R.,Kim, HanSeok IEEE 2017 IEEE communications magazine Vol.55 No.2

<P>The growth of loT is expected to herald a better quality of life and open up new industrial opportunities. However, it is also raising new challenges in resource constrained wireless networks. Originally designed for human-to-human wireless communications, present wireless networks fail to satisfy the huge connectivity and varying traffic requirements of loT. Next generation 5G wireless networks are expected to exploit emerging features, like mmWave, massive MIMO, and C-RAN, for providing the enormous connectivity, resource pooling, and energy efficiency required to support commercial rollout of loT. Exploring these emerging features, we develop 5G-enabled loT gateways to communicate with the RRI Is of 5G C: RAN. The gateways are endowed with efficient compression schemes to significantly improve uplink resource utilization. Our 5G C-RAN prototyping and laboratory experimental results point out a huge opportunity for supporting a massive number of loT-enabled devices by sophisticated 5G C-RAN deployment and efficient loT gateway development.</P>

dsRNA-mediated silencing of chitin synthase A (CHSA) affects growth and development of Leucinodes orbonalis, brinjal fruitand shoot borer

Saxena Shipra,Reddy K.R.K.,Rajam M.V. 한국응용곤충학회 2022 Journal of Asia-Pacific Entomology Vol.25 No.2

Chitin, the second most abundant structural amino polysaccharide in nature, is widely present in insects forming the cuticle and peritrophic membrane. Chitin polymers are formed by polymerization of UDP-Nacetylglucosamine units by chitin synthase (CHS), a conserved enzyme found in all chitin-synthesizing organ isms. In most insect species, two isoforms of CHS have been characterised, namely CHSA, involved in cuticular chitin synthesis and CHSB, involved in formation of the PM. In the present study, the said two isoforms of CHS gene have been identified in Leucinodes orbonalis. Isoforms were found to be differentially expressed at different developmental stages of the insect and down-regulation of the CHSA isoform, manifested an extended larval period, mortality at larval stage as well as reduction in fecundity of the insect pest. Further, systemic RNA interference defective protein (SID), a protein involved in dsRNA transport, was also isolated and was found to be differentially expressed across developmental stages of L. orbonalis. Also, dsRNA supplementation leads to an upregulation in SID transcript levels, suggestive of its involvement in dsRNA transport and processing.

Protective Effect of Panax ginseng extract on Renal Functions Altered by Mercuric Chloride in Albino Rats

Saxena, Prabhu-N.,Mahour, K.,Kumar, Ashok The Korean Society of Ginseng 2006 Journal of Ginseng Research Vol.30 No.3

Liver and kidney are specific organs which play an active role in biotransformation and detoxification mechanisms. Ant adverse effect of chemicals or heavy metal can cause the delay or fade in these mechanisms. Present study was designed to find out the protective effect of Panax ginseng extract on renal functions altered by mercuric chloride (heavy metal) in albino rat. Fifty albino rats were divided into 10 groups. Five groups for acute study and five groups for sud-acute study viz. control group (Tween 20 and distilled water), mercuric chloride treated group (0.926 mg/kg body wt. for acute and 0.044 mg/kg body wt. for sub-acute group after calculated $LD_{50}$ (9.26 mg/kg body wt.) by probit analysis (Finney, 1971), Panax ginseng extract treated group (10 mg/kg body wt. for acute and sub-acute sets), mercuric chloride treated followed by Panax ginseng extract and Panax ginseng extract followed by mercuric chloride group. All doses were given orally by gavage tube. The result revealed that the serum urea and creatinine significantly increased in mercuric chloride treated group, while significantly decreased (p<0.01) in Panax ginseng extract group after acute and sub-acute treatment. The biochemical estimation is also confirmed by nephropathological aspect. However, the Panax ginseng extract treated followed by mercuric chloride group is more prominent than the mercuric chloride treated followed by Panax ginseng extract group. It can be concluded that Panax ginseng extract had a protective nature on renal functions against mercuric chloride toxicity in albino rats.