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RISS 인기검색어
- 검색키워드
- 저자 : Sawakuchi, G O (검색결과 1 건)
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Underwood, T S A,Sung, W,McFadden, C H,McMahon, S J,Hall, D C,McNamara, A L,Paganetti, H,Sawakuchi, G O,Schuemann, J IOP 2017 Physics in medicine & biology Vol.62 No.8
<P>Whilst Monte Carlo (MC) simulations of proton energy deposition have been well-validated at the macroscopic level, their microscopic validation remains lacking. Equally, no gold-standard yet exists for experimental metrology of individual proton tracks. In this work we compare the distributions of stochastic proton interactions simulated using the TOPAS-nBio MC platform against confocal microscope data for Al<SUB>2</SUB>O<SUB>3</SUB>:C,Mg fluorescent nuclear track detectors (FNTDs). We irradiated <img ALIGN='MIDDLE' ALT='$8\times 4\times 0.5$ ' SRC='http://ej.iop.org/images/0031-9155/62/8/3237/pmbaa6429ieqn001.gif'/> mm<SUP>3</SUP> FNTD chips inside a water phantom, positioned at seven positions along a pristine proton Bragg peak with a range in water of 12 cm. MC simulations were implemented in two stages: (1) using TOPAS to model the beam properties within a water phantom and (2) using TOPAS-nBio with Geant4-DNA physics to score particle interactions through a water surrogate of Al<SUB>2</SUB>O<SUB>3</SUB>:C,Mg. The measured median track integrated brightness (IB) was observed to be strongly correlated to both (i) voxelized track-averaged linear energy transfer (LET) and (ii) frequency mean microdosimetric lineal energy, <img ALIGN='MIDDLE' ALT='$\overline{{{y}_{F}}}$ ' SRC='http://ej.iop.org/images/0031-9155/62/8/3237/pmbaa6429ieqn002.gif'/>, both simulated in pure water. Histograms of FNTD track IB were compared against TOPAS-nBio histograms of the number of terminal electrons per proton, scored in water with mass-density scaled to mimic Al<SUB>2</SUB>O<SUB>3</SUB>:C,Mg. Trends between exposure depths observed in TOPAS-nBio simulations were experimentally replicated in the study of FNTD track IB. Our results represent an important first step towards the experimental validation of MC simulations on the sub-cellular scale and suggest that FNTDs can enable experimental study of the microdosimetric properties of individual proton tracks.</P>
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