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ON NEW INEQUALITIES OF SIMPSON'S TYPE FOR GENERALIZED CONVEX FUNCTIONS
Sarikaya, Mehmet Zeki,Budak, Huseyin,Erden, Samet The Kangwon-Kyungki Mathematical Society 2019 한국수학논문집 Vol.27 No.2
In this paper, using local fractional integrals on fractal sets $R^{\alpha}(0<{\alpha}{\leq}1)$ of real line numbers, we establish new some inequalities of Simpson's type based on generalized convexity.
Sarikaya-Bayram, O.,Bayram, O.,Feussner, K.,Kim, J.H.,Kim, H.S.,Kaever, A.,Feussner, I.,Chae, K.S.,Han, D.M.,Han, K.H.,Braus, G.H. Cell Press 2014 DEVELOPMENTAL CELL Vol.29 No.4
Epigenetic and transcriptional control of gene expression must be coordinated in response to external signals to promote alternative multicellular developmental programs. The membrane-associated trimeric complex VapA-VipC-VapB controls a signal transduction pathway for fungal differentiation. The VipC-VapB methyltransferases are tethered to the membrane by the FYVE-like zinc finger protein VapA, allowing the nuclear VelB-VeA-LaeA complex to activate transcription for sexual development. Once the release from VapA is triggered, VipC-VapB is transported into the nucleus. VipC-VapB physically interacts with VeA and reduces its nuclear import and protein stability, thereby reducing the nuclear VelB-VeA-LaeA complex. Nuclear VapB methyltransferase diminishes the establishment of facultative heterochromatin by decreasing histone 3 lysine 9 trimethylation (H3K9me3). This favors activation of the regulatory genes brlA and abaA, which promote the asexual program. The VapA-VipC-VapB methyltransferase pathway combines control of nuclear import and stability of transcription factors with histone modification to foster appropriate differentiation responses.
Sarikaya Bayram, Ö,zlem,Bayram, Ö,zgü,r,Valerius, Oliver,Park, Hee Soo,Irniger, Stefan,Gerke, Jennifer,Ni, Min,Han, Kap-Hoon,Yu, Jae-Hyuk,Braus, Gerhard H. Public Library of Science 2010 PLoS genetics Vol.6 No.12
<▼1><P>VeA is the founding member of the velvet superfamily of fungal regulatory proteins. This protein is involved in light response and coordinates sexual reproduction and secondary metabolism in <I>Aspergillus nidulans</I>. In the dark, VeA bridges VelB and LaeA to form the VelB-VeA-LaeA (velvet) complex. The VeA-like protein VelB is another developmental regulator, and LaeA has been known as global regulator of secondary metabolism. In this study, we show that VelB forms a second light-regulated developmental complex together with VosA, another member of the velvet family, which represses asexual development. LaeA plays a key role, not only in secondary metabolism, but also in directing formation of the VelB-VosA and VelB-VeA-LaeA complexes. LaeA controls VeA modification and protein levels and possesses additional developmental functions. The <I>laeA</I> null mutant results in constitutive sexual differentiation, indicating that LaeA plays a pivotal role in inhibiting sexual development in response to light. Moreover, the absence of LaeA results in the formation of significantly smaller fruiting bodies. This is due to the lack of a specific globose cell type (Hülle cells), which nurse the young fruiting body during development. This suggests that LaeA controls Hülle cells. In summary, LaeA plays a dynamic role in fungal morphological and chemical development, and it controls expression, interactions, and modification of the velvet regulators.</P></▼1><▼2><P><B>Author Summary</B></P><P>Numerous fungi have the potential to infect immunocompromised patients or to contaminate and spoil our nutrients. They represent an increasing danger that threatens public health and agriculture. This requires improved understanding of fungal growth, development, dissemination of spores, and mycotoxin production. We have discovered two related fungal specific protein complexes that provide a molecular link among spore formation, fungal development, and secondary metabolite production. The subunit allocation of both complexes depends on each other, and they share a common subunit. These complexes comprise three related and in fungi conserved proteins of the velvet family that function in concert with a known regulator of secondary metabolism, LaeA. This protein controls the formation of both complexes but is only a part of the trimeric complex. We found that this regulator of secondary metabolism also possesses several developmental control functions in gene expression. These protein complexes discovered in the fungal model system <I>Aspergillus nidulans</I> are conserved in fungal pathogens where they might provide novel insights for understanding growth, development, and interaction with their respective hosts.</P></▼2>
On a New Ostrowski-Type Inequality and Related Results
Set, Erhan,Sarikaya, Mehmet Zeki Department of Mathematics 2014 Kyungpook mathematical journal Vol.54 No.4
We provide a new Ostrowski-type inequality involving functions of two independent variables, as well as some related results.
On weighted generalization of opial type inequalities in two variables
Huseyin Budak,Mehmet Zeki Sarikaya,Artion Kashuri 강원경기수학회 2020 한국수학논문집 Vol.28 No.4
In this paper, we establish some weighted generalization of Opial type inequalities in two independent variables for two functions. We also obtain weighted Opial type inequalities by using $p$-norms. Special cases of our results reduce to the inequalities in earlier study.
Some New Inequalities of Hermite-Hadamard's Type
Saglam, Aziz,Yildirim, Huseyin,Sarikaya, Mehmet Zeki Department of Mathematics 2010 Kyungpook mathematical journal Vol.50 No.3
In this paper, we establish several new inequalities for some differantiable mappings that are connected with the celebrated Hermite-Hadamard integral inequality. Some applications for special means of real numbers are also provided.
Generalization of Hardy-Hilbert's Inequality and Applications
Saglam, Aziz,Yildirim, Huseyin,Sarikaya, Mehmet Zeki Department of Mathematics 2010 Kyungpook mathematical journal Vol.50 No.1
In this paper, by introducing some parameters we establish an extension of Hardy-Hilbert's integral inequality and the corresponding inequality for series. As an application, the reverses, some particular results and their equivalent forms are considered.
( Didem Didar Balci ),( Ebru Celik ),( Gokhan Sarikaya ),( Julide Zehra Yenin ),( Esin Atik ) 대한피부과학회 2011 Annals of Dermatology Vol.23 No.3s
Calcinosis cutis is a condition characterized by the deposition of calcium salts in the skin and subcutaneous tissues, and patients suffering from it encounter various connective tissue disorders, such as dermatomyositis (DM), scleroderma, and systemic lupus erythematosus. Although calcinosis cutis is frequently accompanied by juvenile dermatomyositis, rare cases have been reported in adult patients with DM. On the other hand, lichen sclerosus (LS) is a chronic inflammatory disease of the skin and mucosal surfaces. In the present report, we present a rare case of a 71-year-old patient with DM accompanied by ulcerated calcinosis cutis and vulvar LS. (Ann Dermatol 23(S3) S375~ S379, 2011)