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      • Gastrointestinal Cancer Incidence in East Azerbaijan, Iran: Update on 5 Year Incidence and Trends

        Somi, Mohammad Hossein,Golzari, Mehrad,Farhang, Sara,Naghashi, Shahnaz,Abdollahi, Leila Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.9

        Background: A cancer registry program has been established in East Azerbaijan and this has emphasized the importance of cancers of gastrointestinal tract in this region. The aim of the present pathology-based cancer registry report is to renew epidemiologic aspects of gastrointestinal tract cancers and estimate recent trends. Materials and Methods: A survey team reviewed and collected all records of cancer cases from all referral and valid pathology laboratories of East Azerbaijan province during September 2007-2011. Crude rates, age-specific rates of cancer incidence and annual percent change were calculated. Results: The total newly diagnosed cancer cases (n=6,889)comprised 4,341 males (63.0%) and 2,540 females (36.9%). Gastric cancer was the most common GI tract cancer with an ASR (per $10^5$) of 23.1 for males and 7.69 for females. The ASRs for esophageal and colorectal cancers were 9.69 and 11.2 in males and 7.35 and 8.93 in females. Trend analysis showed a significant decline for esophageal cancer and increasing incidence for colorectal cancer in females. Conclusions: The prevalence of gastric cancer is high in East Azerbaijan province of Iran. This pathology based cancer registry showed an ascending trend for colorectal cancer and decreasing trend for esophageal cancer in females during 2007-2011.

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        The Relationship between Anger Expression and Its Indices and Oral Lichen Planus

        Masoumeh Mehdipour,Ali Taghavi Zenouz,Alireza Farnam,Rana Attaran,Sara Farhang,Maryam Safarnavadeh,Narges Gholizadeh,Saranaz Azari-Marhabi 전남대학교 의과학연구소 2016 전남의대학술지 Vol.52 No.2

        Oral lichen planus (OLP) is a common inflammatory disease with unknown etiology. Depression, stress and anxiety are psychological factors that their influence on the expressionof lichen planus by affecting the immune system’s function has been confirmed. There is a probable relationship between anger and OLP expression. Therefore,the present study aimed to evaluate the association of “anger” and OLP. In this descriptivestudy 95 subjects were included in 3 groups. A: patients with oral lichen planus,B: positive control, C: negative control. Anger and its indices were assessed by theState-Trait Anger Expression Inventory-2 (STAXI-2) questionnaire, and pain wasmeasured via the Visual Analogue Scale (VAS). The collected data were analyzed statisticallyusing SPSS 18 software. The lichen planus and positive control groups borehigher total anger index (AX index) values compared with the negative control. Comparing anger expression-in (AXI) among the lichen planus and negative controlgroups revealed higher grades in lichen planus group. Evaluating the pain severity index(VAS) data and anger indices in lichen planus group, Spearman’s Rank CorrelationTest revealed a significant correlation between TAngR (reactional anger traits) andpain severity. The findings of this study indicated that there was a significant correlationbetween anger control and suppression of lichen planus development. On the otherhand, the patients with more severe pain mostly expressed their anger physically. Based on the findings, we can make the claim that anger suppression and its control-in(gathering tension) may play a role in the development of lichen planus as a knownpsychosomatic disorders.

      • Impact of Tumor Length on Survival for Patients with Resected Esophageal Cancer

        Mirinezhad, Seyed Kazem,Jangjoo, Amir Ghasemi,Seyednejad, Farshad,Naseri, Ali Reza,Mohammadzadeh, Mohammad,Nasiri, Behnam,Eftekharsadat, Amir Taher,Farhang, Sara,Somi, Mohammad Hossein Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.2

        Background: Tumor length in patients with esophageal cancer (EC) has recently received great attention. However, its prognostic role for EC is controversial. The purpose of our study was to characterize the prognostic value of tumor length in EC patients and offer the optimum cut-off point of tumor length by reliable statistical methods. Materials and Methods: A retrospective analysis was conducted on 71 consecutive patients with EC who underwent surgery. ROC curve analysis was used to determine the optimal cut-off point for tumor length, measured with a handheld ruler after formalin fixation. Correlations between tumor length and other factors were surveyed, and overall survival (OS) rates were compared between the two groups. Potential prognostic factors were evaluated by univariate Kaplan-Meier survival analysis. A P value less than 0.05 was considered significant. Results: There were a total of 71 patients, with a male/female divide of 43/28 and a median age of 59. Characteristics were as follows: squamous/adenocarcinoma, 65/6; median tumor length, 4 (0.9-10); cut-off point for tumor length, 4cm. Univariate analysis prognostic factors were tumor length and modality of therapy. One, three and five year OS rates were 84, 43 and 43% for tumors with ${\leq}4cm$ length, whereas the rates were 75, 9 and 0% for tumors >4 cm. There was a significant association between tumor length and age, sex, weight loss, tumor site, histology, T and N scores, differentiation, stage, modality of therapy and longitudinal margin involvement. Conclusions: Future studies for modification of the EC staging system might consider tumor length too as it is an important prognostic factor. Further assessment with larger prospective datasets and practical methods (such as endoscopy) is needed to establish an optimal cut-off point for tumor length.

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