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Santo, Vitor E.,Prieto, Susana,Testera, Ana M.,Arias, Francisco J.,Alonso, Matilde,Mano, Joao F.,Rodriguez-Cabello, Jose Carlos Techno-Press 2015 Biomaterials and biomedical engineering Vol.2 No.1
A bioactive and multifunctional elastin-like polymer (ELP) was produced by genetic engineering techniques to develop new artificial matrices with the ability to mimic the extracellular matrix (ECM). The basic composition of this ELP is a thermo- and pH-sensitive elastin pentapeptide which has been enriched with RGD-containing domains, the RGD loop of fibronectin, for recognition by integrin receptors on their sequence to promote efficient cell attachment. Hydrogels of this RGD-containing polymer were obtained by crosslinking with hexamethylene diisocyanate, a lysine-targeted crosslinker. These materials retain the "smart" nature and temperature-responsive character, and the desired mechanical behavior of the elastin-like polymer family. The influence of the degree of crosslinking on the morphology and properties of the matrices were tested by calorimetric techniques and scanning electron microscopy (SEM). Their mechanical behavior was studied by dynamical mechanical analysis (DMA). These results show the potential of these materials in biomedical applications, especially in the development of smart systems for tissue engineering.
Santo, Vitor E.,Prieto, Susana,Testera, Ana M.,Arias, Francisco J.,Alonso, Matilde,Mano, Joao F.,Rodriguez-Cabello, Jose Carlos Techno-Press 2015 Biomaterials and Biomechanics in Bioengineering Vol.2 No.1
A bioactive and multifunctional elastin-like polymer (ELP) was produced by genetic engineering techniques to develop new artificial matrices with the ability to mimic the extracellular matrix (ECM). The basic composition of this ELP is a thermo- and pH-sensitive elastin pentapeptide which has been enriched with RGD-containing domains, the RGD loop of fibronectin, for recognition by integrin receptors on their sequence to promote efficient cell attachment. Hydrogels of this RGD-containing polymer were obtained by crosslinking with hexamethylene diisocyanate, a lysine-targeted crosslinker. These materials retain the "smart" nature and temperature-responsive character, and the desired mechanical behavior of the elastin-like polymer family. The influence of the degree of crosslinking on the morphology and properties of the matrices were tested by calorimetric techniques and scanning electron microscopy (SEM). Their mechanical behavior was studied by dynamical mechanical analysis (DMA). These results show the potential of these materials in biomedical applications, especially in the development of smart systems for tissue engineering.
Wind turbine maximum power point tracking control based on unsupervised neural networks
Muñoz-Palomeque Eduardo,Sierra-García J Enrique,Santos Matilde 한국CDE학회 2023 Journal of computational design and engineering Vol.10 No.1
The main control goal of a wind turbine (WT) is to produce the maximum energy in any operating region. When the wind speed is under its rated value, the control must aim at tracking the maximum power point of the best power curve for a specific WT. This is challenging due to the non-linear characteristics of the system and the environmental disturbances it is subjected to. Direct speed control (DSC) is one of the main techniques applied to address this problem. In this strategy, it is necessary to design a speed controller to adjust the generator torque so to follow the optimum generator speed. In this work, we improve the DSC by implementing this speed controller with a radial basis function neural network (NN). An unsupervised learning algorithm is designed to tune the weights of the NN so it learns the control law that minimizes the generator speed error. With this proposed unsupervised neural control methodology, the electromagnetic torque that allows the optimal power extraction is obtained, and thus the best power coefficient (${C}_\mathrm{p}$) values. The proposal is tested on the OpenFAST non-linear model of the National Renewable Energy Laboratory 1.5 MW WT. Simulation results prove the good performance of this neuro-control approach as it maintains the WT variables into the appropriate range and tracks the rated operation values. It has been compared with the controller included in OpenFAST giving up to 7.87% more power.