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Quantitative Analysis and Efficient Surface Modification of Silica Nanoparticles
Jung, Hak-Sung,Moon, Doo-Sik,Lee, Jin-Kyu Hindawi Limited 2012 Journal of nanomaterials Vol.2012 No.-
<P>Aminofunctional trialkoxysilanes such as aminopropyltrimethoxysilane (APTMS) and (3-trimethoxysilylpropyl)diethylenetriamine (DETAS) were employed as a surface modification molecule for generating monolayer modification on the surface of silica (SiO2) nanoparticles. We were able to quantitatively analyze the number of amine functional groups on the modified SiO2nanoparticles by acid-base back titration method and determine the effective number of amine functional groups for the successive chemical reaction by absorption measurements after treating with fluorescent rhodamine B isothiocyanate (RITC) molecules. The numbers of amine sites measured by back titration were 2.7 and 7.7 ea/nm<SUP>2</SUP>for SiO2-APTMS and SiO2-DETAS, respectively, while the numbers of effective amine sites measured by absorption calibration were about one fifth of the total amine sites, namely, 0.44 and 1.3 ea/nm<SUP>2</SUP>for SiO2-APTMS(RITC) and SiO2-DETAS(RITC), respectively. Furthermore, it was confirmed that the reactivity of amino groups on the surface-modified silica nanoparticles could be maintained in ethanol for more than 1.5 months without showing any significant differences in the reactivity.</P>
Jung, Kyung-Kwon,Lim, Joong-Kyu,Chung, Sung-Boo,Eom, Ki-Hwan The Korea Institute of Information and Commucation 2003 Journal of information and communication convergen Vol.1 No.3
We propose a learning method for improving the performance of the backpropagation algorithm. The proposed method is using a fuzzy logic system for automatic tuning of the learning rate of each weight. Instead of choosing a fixed learning rate, the fuzzy logic system is used to dynamically adjust the learning rate. The inputs of fuzzy logic system are delta and delta bar, and the output of fuzzy logic system is the learning rate. In order to verify the effectiveness of the proposed method, we performed simulations on the XOR problem, character classification, and function approximation. The results show that the proposed method considerably improves the performance compared to the general backpropagation, the backpropagation with momentum, and the Jacobs'delta-bar-delta algorithm.
Simultaneous Glossectomy with Orthognathic Surgery for Mandibular Prognathism
Jung, Young-Wook,On, Sung-Woon,Chung, Kyu-Rhim,Song, Seung-Il Korean Association of Maxillofacial Plastic and Re 2014 Maxillofacial Plastic Reconstructive Surgery Vol.36 No.5
Macroglossia can create dental and skeletal instability after orthodontic treatment or orthognathic surgery for mandibular prognathism. In relevant literature, partial glossectomy is suggested for a good post-treatment prognosis. Most of the published partial glossectomy cases are two-staged surgery, because of concern about postoperative airway obstruction. As orthognathic surgical techniques and fixation method develop, however, concerns about postoperative airway obstruction have lessened. In this case, mandibular setback surgery and partial glossectomy were performed simultaneously, leading to stable recovery without any postoperative respiratory problems. After surgical technique to preserve the tongue tip, we achieved good outcomes without postoperative side effects of lingual hypoesthesia, pronunciation disorder and dyskinesia. We report this case with a literature review.
LB30057 Inhibits Platelet Aggregation and Vascular Relaxation Induced by Thrombin
Jung, Byoung-In,Kang, a-Kyu-Tae,Bae, Ok-Nam,Lee, Moo-Yeol,Chung, Seung-Min,Lee, Sang-Koo,Kim, In-Chul,Chung, Jin-Ho The Pharmaceutical Society of Korea 2002 Archives of Pharmacal Research Vol.25 No.6
Previous study showed that an amidrazonophenylalanine derivative, LB30057, which has high water solubility, inhibited the catalytic activity of thrombin potently by interaction with the active site of thrombin. In the current investigation, we examined whether LB30057 inhibited platelet aggregation and vascular relaxation induced by thrombin. Treatment with LB30057 to plateletrich plasma (PRP) isolated from human blood resulted in a concentration-dependent inhibition of thrombin-induced aggregation. Values for $IC_{50}$ and $IC_{100}$ were $54{\pm}4$ nM and $96{\pm}3$ nM, respectively. This inhibition was agonist (thrombin) specific, since $IC_{50}$ values for collagen and ADP were \much greater than those for thrombin. In addition, concentration-dependent inhibitory effects were observed on the serotonin secretion induced by thrombin in PRP. Consistent with these findings, thrombin-induced increase in cytosolic calcium levels was inhibited in a concentration-dependent manner. When LB30057 was treated with aortic rings isolated from rats, LB30057 resulted in a concentration-dependent inhibition of thrombin-induced vascular relaxation. All these results suggest that LB30057 is a potent inhibitor of platelet aggregation and blood vessel relaxation induced by thrombin.
Clinical Significance of Subjective Foamy Urine
Kyu Keun Kang,Jung Ran Choi,Ji Young Song,Sung Wan Han,So Hyun Park,Woong Sun Yoo,Hwe Won Kim,Dongyoung Lee,Kyoung Hyoub Moon,Myung Hee Lee,Beom Kim 전남대학교 의과학연구소 2012 전남의대학술지 Vol.48 No.3
Foamy urine is widely regarded as a sign of proteinuria. However, there is no objective definition of foamy urine and there are no reports on the proportion of involved patients who have overt proteinuria or microalbuminuria. We performed this study to investigate this proportion and to identify possible risk factors for these two conditions. We reviewed all new outpatients from 1 November 2011 to 30 April 2012 and identified patients complaining of foamy urine. Their demographic data and medical records were examined. In particular, we tabulated the patients’ spot urinary protein to creatinine ratio, spot urinary microalbumin to creatinine ratio (ACR), blood urea nitrogen (BUN),and serum levels of creatinine (Cr), uric acid, calcium, phosphate, and glucose. In addition,we calculated estimated glomerular filtration rates (eGFRs) by using the CKD-EPI equation. We also performed risk factor analysis with the Chi-squared test and by logistic regression. Seventy-two patients (6.3% of total new outpatients) complained of foamy urine; of these, there were 59 males with a median age of 65.5 years (range, 36-87 years). Of the 72 patients, 16 (22.2%) had overt proteinuria. We found that diabetes, poor renal function (high Cr, BUN, low eGFR), increased serum phosphate,and increased serum glucose were associated with overt proteinuria. Multiple logistic regression analysis showed that serum Cr and serum phosphate were associated with overt proteinuria. The ACR was available for 38 patients, and in this subgroup,12 (31.6%) showed microalbuminuria or overt proteinuria. In this subgroup, a high serum Cr was the only statistically significant risk factor. Among patients who complained of foamy urine, approximately 20% had overt proteinuria, and increased serum Cr and phosphate were statistically significant risk factors.
Jung, Sung Hun,Kim, Chang-Kyu,Lee, Gunhee,Yoon, Jonghwan,Lee, Minho Korea Genome Organization 2017 Genomics & informatics Vol.15 No.4
More effective production of human insulin is important, because insulin is the main medication that is used to treat multiple types of diabetes and because many people are suffering from diabetes. The current system of insulin production is based on recombinant DNA technology, and the expression vector is composed of a preproinsulin sequence that is a fused form of an artificial leader peptide and the native proinsulin. It has been reported that the sequence of the leader peptide affects the production of insulin. To analyze how the leader peptide affects the maturation of insulin structurally, we adapted several in silico simulations using 13 artificial proinsulin sequences. Three-dimensional structures of models were predicted and compared. Although their sequences had few differences, the predicted structures were somewhat different. The structures were refined by molecular dynamics simulation, and the energy of each model was estimated. Then, protein-protein docking between the models and trypsin was carried out to compare how efficiently the protease could access the cleavage sites of the proinsulin models. The results showed some concordance with experimental results that have been reported; so, we expect our analysis will be used to predict the optimized sequence of artificial proinsulin for more effective production.
Jung, Kwang Hwa,Kim, Jeong Kyu,Kim, Min Gyu,Noh, Ji Heon,Eun, Jung Woo,Bae, Hyun Jin,Chang, Young Gyoon,Shen, Qingyu,Park, Won Sang,Lee, Jung Young,Nam, Suk Woo American Chemical Society 2012 Environmental science & technology Vol.46 No.23
<P>Persistent organic pollutants (POPs) are degradation-resistant anthropogenic chemicals that accumulate in the food chain and in adipose tissue, and are among the most hazardous compounds ever synthesized. However, their toxic mechanisms are still undefined. To investigate whether characteristic molecular signatures can discriminate individual POP and provide prediction markers for the early detection of POPs exposure in an animal model, we performed transcriptomic analysis of rat liver tissues after exposure to POPs. The six different POPs (toxaphene, hexachlorobenzene, chlordane, mirex, dieldrin, and heptachlor) were administered to 11-week-old male Sprague-Dawley rats, and after 48 h of exposure, RNAs were extracted from liver tissues and subjected to rat whole genome expression microarrays. Early during exposure, conventional toxicological analysis including changes in the body and organ weight, histopathological examination, and blood biochemical analysis did not reflect any toxicant stresses. However, unsupervised gene expression analysis of rat liver tissues revealed in a characteristic molecular signature for each toxicant, and supervised analysis identified 2708 outlier genes that discerned the POPs exposure group from the vehicle-treated control. Combination analysis of two different multiclassifications suggested 384 genes as early detection markers for predicting each POP exposure with 100% accuracy. The data from large-scale gene expression analysis of a different POP exposure in rat model suggest that characteristic expression profiles exist in liver hepatic cells and multiclassification of POP-specific molecular signatures can discriminate each toxicant at an early exposure time. The use of these molecular markers may be more widely implemented in combination with more traditional techniques for assessment and prediction of toxicity exposure to POPs from an environmental aspect.</P>