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Effects of 3 - Aminobenzamide on Polymerase α - dependent DNA Repair
박종근,변미경,박상대 ( Jong Kun Park,Mee Kyeong Byeon,Sang Dai Pak ) 한국유전학회 1986 Genes & Genomics Vol.8 No.1
The action of 3-aminobenzamide (3AB), an inhibitor of poly (ADP-ribose) polymerase, synergistically enhanced the amount of unscheduled DNA synthesis and DNA strand breaks in asynchronous CHO (Chinese hamster ovay)-K 1 cells exposed to methylmethane sulfonate (MMS). In this system, the time dependent decrease in the strand breaks was inhibited by 3AB. In synchronous CHO-K 1 cells, however, the sensitivity of exonuclease II on the repair patches blocked by aphidicolin, the inhibitor of DNA polymerase showed nonsignificant difference between normal-and 3AB-chased groups. Similarly, the rate of removal of exo II-sensitive sites was not altered by 3AB in WIL-2 (human lymphoid) cells. These results, therefore, suggest that poly (ADP-ribose) polymerization does not exert any significant role in the ligation of polymerase-dependent repair synthesis induced by MMS.