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Sagong, Borum,Jung, Da Jung,Baek, Jeong-In,Kim, Min-A,Lee, Jaetae,Lee, Sang-Heun,Kim, Un-Kyung,Lee, Kyu-Yup Institute for Clinical Science] 2014 Annals of clinical and laboratory science Vol.44 No.4
<P>Craniosynostosis is a heterogeneous disorder that results in a common malformation which causes premature fusion of one or more cranial sutures. Whole-exome sequencing (WES) was recently developed as a powerful genetic strategy for identifying pathogenic mutations of heterogeneous disorders with various causative genes. A 24-year-old woman visited our department for evaluation of persistent hearing impairment and absence of an external auditory canal from birth. In this study, we performed WES to identify the causative mutation in a Korean family who has Crouzon Syndrome (CS). We first focused on 16 genes associated with craniosynostosis and sorted the heterozygous variations according to the autosomal dominant inheritance pattern of her family. After the bioinformatic analysis for filtering and detecting variations, three non-synonymous variations in different genes were selected for additional analysis. Among these, the p.C278F mutation in the FGFR2 gene was only absent from both dbSNP and the 1000 Genomes database. We considered the p.C278F mutation in the FGFR2 gene as the causative mutation for the CS. This result suggests that the application of WES will be valuable for diagnosis of congenital disorders with clinical and genetics heterogeneities.</P>
Discrete Variable Structure Controller with Integrator for Uncertain Systems
Sagong, Seong-Dae 永同大學校 1999 硏究論叢 Vol.5 No.1
본 연구에서는 불확실성을 가지는 서보 시스템에 대하여 적분기를 포함하는 이산 시간 가변구조 제어에 관하여 살펴보았다. 이 적분기를 포함하는 이산시간 가변구조 제어는 서보 시스템의 응답에서 발생하는 정상상태 오차를 제거할 수 있는 특징을 가지고 있다. 불확실성을 포함하는 시스템에 대하여 제안한 이산시간 가변구조 제어가 슬라이딩 모드에서 채터링을 제거할 수 있음을 살펴보았다. 그리고 제아한 알고 리듬의 타당성을 시뮬레이션을 통하여 확인하였다. In this paper, a discrete variable structure control(DVSC) with integrator for servo systems with uncertainty is proposed. The DVSC with integrator which eliminates the steady-state error that is happened for the reference input in the servo systems is proposed. For systems with uncertainty, we design a DVSC which guarantees the robustness of uncertain systems and which has an advantage of elimination of the chattering in the sliding mode. Finally, the simulation results show the effectiveness of the proposed algorithm.
SAGONG, HUN-GU,PARK, SANG-HYUN,CHOI, YOUNG-JIN,RYU, SANGRYEOL,KANG, DONG-HYUN International Association for Food Protection 2011 Journal of food protection Vol.74 No.6
<P>The effects of ohmic heating on reduction of Escherichia coli O157:H7, Salmonella Typhimurium, and Listeria monocytogenes in orange and tomato juice were investigated. Orange and tomato juice inoculated with E. coli O157:H7, Salmonella Typhimurium, and L. monocytogenes were subjected to ohmic heating with selected parameters including electric field strength from 10 to 20 V/cm and treatment times from 0 to 540 s. The number of pathogens was reduced by increasing the electric field strength from 10 to 20 V/cm as well as increasing treatment time. The population of E. coli O157:H7 was reduced more than 5 log after 120, 210, and 540 s of treatment in orange juice with 20, 15, and 10 V/cm electric field strengths, respectively. In tomato juice, levels of E. coli O157:H7 were reduced more than 5 log after 90, 180, and 480 s with the same electric field strengths. Similar phenomena were observed for Salmonella Typhimurium and L. monocytogenes, but E. coli O157:H7 was the most resistant to ohmic heating treatment. These results show that ohmic heating is potentially useful for inactivation of E. coli O157:H7, Salmonella Typhimurium, and L. monocytogenes and that the effect of inactivation depends on applied electric field strength, treatment time, pathogen species, and type of juice.</P>
『속된 무리를 떠나서』에 나타난 밧세바의 여성 정체성 탐구 — 포스트콜로니얼의 페미니즘 관점에서
Sagong, Chaul 한국중앙영어영문학회 2016 영어영문학연구 Vol.58 No.4
The purpose of this research is to search feminine identity of Bathsheba on postcolonial feminism in Thomas Hardy’s Far from the Madding Crowd. During Thomas Hardy’s times, the setting for English social change was the industrialization through rapid scientific developments. In a society like this, the social lives of the contemporary women were limited because of exclusive values of social status, sexual ideology, education, religion, marriage, gender difference, and confinement of the class, yet Bathsheba who is suspicious of the contemporary male-centered society restructures her own status and feminine identity, breaking the conventional patterns of the male and the female. The romance of Bathsheba is made up of such main components as work, money, social status, and masculinity in which woman is considered as an economic subject of contemporary society. In this view, this study is to analyze the “Androgyny” of Bathsheba from the viewpoint of the postcolonial feminism, by comprehensively understanding feminine identity of Bathsheba in Far from the Madding Crowd.
S.-T. Kwon,C.- S. Cheong,H. Sagong 한국지질과학협의회 2006 Geosciences Journal Vol.10 No.2
Sagong, H., Kwon, S.-T., and Ree, J.-H., 2005, Mesozoic episodicmagmatism in South Korea and its tectonic implication. Tecton-ics, 24, TC5002, doi:10.1029.
Sagong, Hye-Young,Kim, Kyung-Jin American Chemical Society 2015 Journal of agricultural and food chemistry Vol.63 No.49
<P>Tetrahydrodipicolinate <I>N</I>-succinyltransferase (DapD) is an enzyme involved in the biosynthesis of <SMALL>l</SMALL>-lysine by converting tetrahydrodipicolinate into <I>N</I>-succinyl-<SMALL>l</SMALL>-2-amino-6-oxopimelate, using succinyl-CoA as a cofactor. We determined the crystal structure of DapD from <I>Corynebacterium glutamicum</I> (<I>Cg</I>DapD). <I>Cg</I>DapD functions as a trimer, and each monomer consists of three domains: an N-terminal helical domain (NTD), a left-handed β-helix (LβH) domain, and a β C-terminal domain (CTD). The mode of cofactor binding to <I>Cg</I>DapD, elucidated by determining the structure in complex with succinyl-CoA, reveals that the position of the CTD changes slightly as the cofactor binds to the enzyme. The superposition of this structure with that of <I>Mycobacterium tuberculosis</I> shows differences in residues that make up cofactor-binding sites. Moreover, we determined the structure of <I>Cg</I>DapD in complex with the substrate analogue 2-aminopimelate and revealed that the analogue was stabilized by conserved residues. The catalytic and substrate binding sites of <I>Cg</I>DapD were confirmed by site-directed mutagenesis experiments.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jafcau/2015/jafcau.2015.63.issue-49/acs.jafc.5b04785/production/images/medium/jf-2015-04785n_0006.gif'></P>
Analytical Solution of ECV Tracking Filter with Two Measurements Based on a Eigenstructure Method
Sagong, Seong Dae 永同大學校 1997 硏究論叢 Vol.3 No.1
MacFarlane-Potter-Fath 고유 구조 방법을 이용하여 위치와 속도 측정치를 가지는 두 상태 ECV 목표 추적 필터의 해석적 정상 상태 해를 유도한다. 정상 상태 해는 백색 잡음의 기동 성능이라는 가정 하에 해석적으로 얻어진다. 필터 이득 그래프들은 두 측정치를 가지는 필터의 해와 고유 구조 방법을 이용한 해석적 해들의 유효성을 보여준다. Using MacFarlane-Potter-Fath eigenstructure method, analytical steady-state solutions of two-state exponentially correlated velocity(ECV) target-tracking filter with the position and velocity measurements are derived. The steady-state solutions are analytically obtained under the assumption of white noise maneuver capability. Graphs of the filter gains show the solutions for the filter with two measurements are available and the effectiveness of the obtained analytical solutions by using the eigenstructure method.
Sagong, Borum,Park, Raekil,Kim, Yee Hyuk,Lee, Kyu-Yup,Baek, Jeong-In,Cho, Hyun-Joo,Cho, In-Jee,Kim, Un-Kyung,Lee, Sang-Heun Institute for Clinical Science] 2010 Annals of clinical and laboratory science Vol.40 No.4
<P>The TECTA gene, which encodes alpha-tectorin, is known as a causative gene for DFNA8/DFNA12, and DFNB21 hearing loss in humans. In the present study, mutation analysis of the TECTA gene was performed in 62 Korean patients with hereditary hearing loss. Two novel nucleotide substitutions, p.V317E and p.T1866M, were identified for the first time in the Korean population. These mutations result in the substitution of amino acids in the zonadhesin (ZA) and the zona pellucida (ZP) domains, and show a genotype-phenotype correlation, which is a characteristic of TECTA-related mutations in autosomal dominant nonsyndromic hearing loss. Both mutations are located in highly conserved regions of alpha-tectorin and were not found in 120 unrelated control subjects with normal hearing. Based on this evidence, it is likely that both mutations are the pathogenic ones causing the hearing loss. This study provides useful information for the functional study of hereditary hearing loss caused by tectorial membrane defects.</P>