<i>CYP2A6</i> and <i>ERCC1</i> polymorphisms correlate with efficacy of S-1 plus cisplatin in metastatic gastric cancer patients

Park, S R,Kong, S-Y,Nam, B-H,Choi, I J,Kim, C G,Lee, J Y,Cho, S J,Kim, Y W,Ryu, K W,Lee, J H,Rhee, J,Park, Y-I,Kim, N K Nature Publishing Group 2011 The British journal of cancer Vol.104 No.7

<P><B>Background:</B></P><P>We evaluated the association between polymorphisms of cytochrome P450 2A6 (<I>CYP2A6</I>)/excision repair cross-complementation group 1 (<I>ERCC1</I>)/X-ray repair cross-complementing group 1(<I>XRCC1</I>) and treatment outcomes of metastatic gastric cancer (MGC) patients treated with S-1/cisplatin.</P><P><B>Methods:</B></P><P>Among MGC patients (<I>n</I>=108), who received S-1 (40 mg m<SUP>−2</SUP> b.i.d., days 1–14) and cisplatin (60 mg m<SUP>−2</SUP>, day 1) every 3 weeks, we analysed the wild-type allele (<I>W</I>) and variants (<I>V</I>) of <I>CYP2A6</I> (<I>*4</I>, <I>*7, *9, *10</I>), and the polymorphisms of <I>ERCC1</I> (rs11615, rs3212986) and <I>XRCC1</I> (rs25487).</P><P><B>Results:</B></P><P>Patients having fewer <I>CYP2A6</I> variants had better response rates (<I>W</I>/<I>W vs W</I>/<I>V</I> other than <I>*1/*4 vs V</I>/<I>V</I> or <I>*1/*4</I>=66.7 <I>vs</I> 58.3 <I>vs</I> 32.3% <I>P</I>=0.008), time to progression (TTP) (7.2 <I>vs</I> 6.1 <I>vs</I> 3.5 months, <I>P</I>=0.021), and overall survival (23.2 <I>vs</I> 15.4 <I>vs</I> 12.0 months, <I>P</I>=0.004). <I>ERCC1 19442C</I>><I>A</I> (rs3212986) was also associated with response rate (<I>C/C</I>, 46.7% <I>vs C/A</I>, 55.3% <I>vs A/A</I>, 87.5%) (<I>P</I>=0.048) and TTP (4.4 <I>vs</I> 7.6 <I>vs</I> 7.9 months) (<I>P</I>=0.012). Patients carrying both risk genotypes of <I>CYP2A6</I> (<I>V</I>/<I>V</I> or <I>1/*4</I>) and <I>ERCC1 19442C</I>><I>A</I> (<I>C/C</I>) <I>vs</I> those carrying none showed an adjusted odds ratio of 0.113 (<I>P</I>=0.004) for response, and adjusted hazard ratios of 3.748 (<I>P</I>=0.0001) for TTP and 2.961 (<I>P</I>=0.006) for death.</P><P><B>Conclusion:</B></P><P>Polymorphisms of <I>CYP2A6</I> and <I>ERCC1 19442C</I>><I>A</I> correlated with the efficacy of S-1/cisplatin.</P>

Novel method for investigation of a K-Mg-based CO₂ sorbent for sorption-enhanced water-gas shift reaction

Byun, C.K.,Kwon, S.J.,Im, H.B.,Ahn, H.S.,Ryu, H.J.,Yi, K.B. Pergamon Press 2016 RENEWABLE ENERGY Vol.87 No.1

CO<SUB>2</SUB> sorption reactions at 20 bar and two different temperatures (i.e., 180 and 220 <SUP>o</SUP>C) using a K-Mg-based CO<SUB>2</SUB> sorbent were carried out in a custom-designed high-pressure thermogravimetric analyzer (pressurized bubbling fluidized bed reactor on a scale) coupled with a gas chromatograph. The experimental apparatus, including the thermogravimetric analyzer, was custom-designed to measure weight changes caused by either CO<SUB>2</SUB> sorption or water sorption or both. Analysis of the CO<SUB>2</SUB> sorption reaction revealed that water sorption takes place rapidly with a moderate CO<SUB>2</SUB> sorption rate at the early stage of the reaction. Then, the reaction migrates to CO<SUB>2</SUB> sorption with simultaneous water desorption. Therefore, the mechanism of the CO<SUB>2</SUB> sorption reaction is assumed to consist of fast hydration of K<SUB>2</SUB>CO<SUB>3</SUB> and MgO, formation and decomposition of KHCO<SUB>3</SUB>, and finally carbonation of Mg(OH)<SUB>2</SUB> resulting in MgCO<SUB>3</SUB> as the main product. K<SUB>2</SUB>CO<SUB>3</SUB> is assumed to provide an efficient pathway for CO<SUB>2</SUB> and water to travel into the core region of the sorbent via a reversible reaction between K<SUB>2</SUB>CO<SUB>3</SUB> and KHCO<SUB>3</SUB>.

Pb(Zr,Ti)O₃-Pb(Mn_1/3Nb_2/3)O₃ piezoelectric thick films by aerosol deposition

Ryu, J.,Choi, J.J.,Hahn, B.D.,Yoon, W.H.,Lee, B.K.,Choi, J.H.,Park, D.S. Elsevier Sequoia 2010 Materials Science and Engineering B Vol. No.

<P>Piezoelectric thick films of Pb(Zr,Ti)O-3-Pb(Mn1/3Nb2/3)O-3 (PZT-PMnN) with Zr:Ti ratios ranging from 0.45:0.55 to 0.60:0.40 were fabricated on a platinized silicon wafer by aerosol deposition (AD). All the films were deposited with a thickness of 10 mu m with high density. By adding PMnN to 57:43 PZT, a dielectric constant as low as similar to 660 was achieved while the effective piezoelectric constant was over 140 pC/N. PZT-PMnN with a Zr:Ti ratio of 57:43 thus showed a maximum piezoelectric voltage constant (g(33)) of 23.8 x 10(-3) Vm/N and is a good candidate for high quality thick films for application to high-energy density or high sensitivity, piezoelectric energy harvesters and sensors. (C) 2010 Elsevier B.V. All rights reserved.</P>

Simulation and Optimization of Penicillin Amidohydrolase Enzyme Reactor System

Ryu,D Y,Lee,B K 한국화학공학회 1973 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.11 No.3

The activity of penicillin amidase obtained from B. megaterium and M. roseus were compared with that obtained from other microbial sources. By using both the soluble and immobilized forms of the enzyme obtained from B. megaterium, we have studied the reaction kinetics. The products of the enzymatic hydrolysis of benzylpenicillin, PAA and 6-APA, have been found to be competitive and noncompetitive inhibitors of the enzyme, respectively. We have developed a kinetic model of the reaction based on this finding and a mathematical model for a continuous enzyme reactor system was formulated. With the aid of a computer, simulation studies of the enzyme reactor systems were carried out, and the results compared favorably with the experimental results. The productivity (defined as moles of product formed per liter of reactor volume per hour) was optimized with respect to the space time of the reactor system and the concentration of the substrate in the feed. It was found that the productivity of the immobilized enzyme reactor system was more favorable as compared with the soluble enzyme reactor system under certain operating conditions.

OGLE-2016-BLG-0693LB: Probing the Brown Dwarf Desert with Microlensing

Ryu, Y.-H.,Udalski, A.,Yee, J. C.,Albrow, M. D.,Chung, S.-J.,Gould, A.,Han, C.,Hwang, K.-H.,Jung, Y. K.,Shin, I.-G.,Zhu, W.,Cha, S.-M.,Kim, D.-J.,Kim, H.-W.,Kim, S.-L.,Lee, C.-U.,Lee, Y.,Park, B.-G.,P American Astronomical Society 2017 The Astronomical journal Vol.154 No.6

<P>We present an analysis of microlensing event OGLE-2016-BLG-0693, based on the survey-only microlensing observations by the OGLE and KMTNet groups. In order to analyze the light curve, we consider the effects of parallax, orbital motion, and baseline slope, and also refine the result using a Galactic model prior. From the microlensing analysis, we find that the event is a binary composed of a low-mass brown dwarf (49(-18)(+20) Mj) companion and a K- or G-dwarf host, which lies at a distance of 5.0 +/- 0.6 kpc toward the Galactic bulge. The projected separation between the brown dwarf and its host star is less than similar to 5 au, thus it is likely that the brown dwarf companion is located in the brown dwarf desert.</P>

Effect of Crystallization Treatment on the Magnetic Properties of Amorphous Strips Based on Co-Fe-Ni-B-Si-Cr Containing Nitrogen

Cho H.J.,Kwon H.T.,Ryu H.H.,Sohn K.Y.,You B.S.,Park W.W. The Korean Powder Metallurgy Institute 2006 한국분말재료학회지 (KPMI) Vol.13 No.4

Co-Fe-Ni-B-Si-Cr based amorphous strips containing nitrogen were manufactured via melt spinning, and then devitrified by crystallization treatment at the various annealing temperatures of $300^{\circ}C{\sim}540^{\circ}C$ for up to 30 minutes in an inert gas $(N_2)$ atmosphere. The microstructures were examined by using XRD and TEM and the magnetic properties were measured by using VSM and B-H meter. Among the alloys, the amorphous ribbons of $Co_{72.6}Fe_{9.8}Ni_{5.5}B_{2.4}Si_{7.1}Cr_{2.6}$ containing 121 ppm of nitrogen showed relatively high saturation magnetization. The alloy ribbons crystallized at $540^{\circ}C$ showed that the grain size of $Co_{72.6}Fe_{9.8}Ni_{5.5}B_{2.4}Si_{7.1}Cr_{2.6}$ alloy containing 121 ppm of nitrogen was about f nm, which exhibited paramagnetic behavior. The formation of nano-grain structure was attributed to the finely dispersed Fe4N particles and the solid-solutionized nitrogen atoms in the matrix. Accordingly, it can be concluded that the nano-grain structure of 5nm in size could reduce the core loss within the normally applied magnetic field of 300A/m at 10kHz.

란타노이드계 페롭스카이트형 촉매에서 입자상물질의 산화반응

조경목,오광중,박대원,홍성수,양진섭,류봉기 한국공업화학회 1998 응용화학 Vol.2 No.1

We have studied the catalytic combustion of soot particulate over perovskitetype oxides prepared by malic acid method. The catalysts were modified to enhance the activity by substitution of metal into A or B site of perovskite oxide. In addition, the reaction conditions, such as temperature, O₂ concentration, space velocity have been studied. The effect of SO₂ pretreatment and water introduced into reactants were also examined. In the LaCoO₃ catalyst, the partial substitution of alkali metals into A site enhanced the catalytic activity in the combustion of soot particulate and the activity was shown in the order: Cs$gt;K$gt;Na; In the Lao_0.6Cs_(0.4)CoO₃ catalyst, the substitution of Fe or Mn showed no effect on the ignition temperature. The ignition temperature decreased with increasing O₂ concentration and contact time. The introduction of water into reactants feed decreased the ignition temperature and the pretreatment of SO₂ showed no effect on the catalytic activity.

각종 심질환에서의 방사성 동위원소 심혈관 조영술에 관한 연구

조보연,고창순,정준기,박선양,김병국,류박영 대한핵의학회 1979 핵의학 분자영상 Vol.13 No.1

비관혈적 방법인 방사성동위원소 심혈관조영술 정성적 및 정량적인 분석을 시도하고자 1979년 3월부터 9월까지 서울대학병원에 입원한 각종 심질환환자 147명과 정상대조군 26명을 대상으로 방사성동위원소 심혈관찰영술을 시행하여 다음과같은 결과를 얻었다. 1) 심도자법으로 단락이 확진된 좌우단락 24예중 22예에서 진단할 수 있었고, 심장단락 21예에서는 전예에서 진단이 가능하였다. 방사성 동위원소법으로 좌우단락을 진단할 수 있는 최소의 Qp/Qs비는 1.3이었다. 2) 폐의 시간일방사능유선에서 최대방사능치(C1)와 같은 시간 뒤의 방사능치(C2)의 비 C2/C1는 정상대조군에서는 28.6±4.6%(21∼38%)이었고, 좌우단락에서는 67.8±12.2%로 정상대조군에 비하여 현저히 증가되어 있었다(P$lt;0.01). 3) 좌우단락 8예에서의 폐의 시간일방사능유선을 이용하여 구한 Qp/Qs비는 oxymetry법에 의한 Qp/Qs비와 유의한 상관관계가 있었다(상관계수 0.907, P$lt;0.01). 4) 개심수술후 단락의 교정여부를 방사성동위원소 심혈관조영술로 쉽게 확인할 수 있었다. 이상의 성적으로 방사성동위원소 심혈관조영술은 간단하고 안전하게 심장단락의 정성적 및 정량적인 분석을 할 수 있었으며 그 성적이 심도자법과 비교하여 높은 정확도를 보이고 있음을 알 수 있었고 반복시행이 용이하기 때문에 수술 후의 교정 여부도 쉽게 판정 할 수 있어 임상적으로 크게 유용하다고 생각되었다. Radionuclidd cardiac angiography has distinct advantages in safety, patient comfort, cost and ease of performance. This method offers diagnostic accuracy equivalent to that of cardiac catheterization. By this method the qualitative and quantitative diagnosis of the cardiac shunts are available. Also for it is repeatable tvith ease and more physiologic, it has application in following pre- and post-operative shunt patients. We performed the radionuclide cardiac angiographies in 147 cases of heart diseases and 26 cases of normal group. 1) The detection of left-to-right shunt was possible in 22 of 24 patients, and 2 patients were not diagnosed due to small shunt amount.(Qp/Qs$lt;l. 3) In 21 patients of right-to-left shunt, all were diagnosed by radionuclide cardiac angiography. 2) With the pulmonary time-activity curve, C2/C1 ratio was calculated. In normal control group, a range of C2/C1 ratios of 21∼38% was established with a mean value of 28.6±4.6%. In patients with left-to-right shunts determined by catheterizion data, the range of C2/C1 ratio was 33∼90%, with a mean value of 67.8±12.2%. 3) In 8 cases of left-to-right shunt, Qp/Qs ratios determined by radionuclide cardiac angiography were compaired with those of cardiac catheterization. The correlation coefficient was 0.907. (P$lt;0.001) 4) Postoperative radionuclide cardiac angiographies were clone in 21 cases. 3 of 13 patients with left-to-right shunts were found to have residual shunts. 8 patients with right-to-left shunts were confirmed to have no residual shunt.

비정질 리본의 자기변형 측정용 광섬유 변위센서

유권상(K. S. Ryu),김철기(C. G. Kim),김중복(J. B. Kim),김현아(H. A. Kim) 한국자기학회 1996 韓國磁氣學會誌 Vol.6 No.1

We have constructed a displacement sensor for measuring dynamic magnetostriction of an amorphous ribbon under alternating magnetic field using fiber optic Fabry-Perot interferometer. The signal of the sensor was dependent on the index matching oil and the optical isolator. The resolution of the sensor was 30 Å and the measured peak to peak magnetostriction of the amorphous ribbon Fe_(81)B_(13.5)Si_(3.5)C₂ was 28×10^(-6).

Characteristics of a Bi-2212 Monofilar Superconducting Fault Current Limiting Element

Jin, H.B.,Li, Z.Y.,Ma, Y.H.,Ryu, K.,Park, K.B.,Oh, I.S. IEEE 2009 IEEE transactions on applied superconductivity Vol.19 No.3

<P>The Bi-2212 monofilar bulk element was selected as a candidate in developing a 24 kV/630 A class superconducting fault current limiting (SFCL) system. This study investigated the Bi-2212 monofilar element both experimentally and theoretically regarding the DC voltage-current characteristics, AC loss characteristics, inductance, current limiting characteristics and local temperature distribution. It was found that the critical current of the Bi-2212 monofilar element increased 3.3 times as the operation temperature decreased from 77 K to 65 K. Although the arrangement of the Bi-2212 conductor was a coil shape, the measured AC loss was at a level similar to what is calculated from the Norris equation at both the temperatures 77 K and 65 K. The temperatures measured at each section during a fault were in good agreement with the results of the numerical analysis. Moreover, the results showed that the monofilar element was not yet sufficiently homogeneous to be used at its full rated voltage.</P>