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RISS 인기검색어
- 검색키워드
- 저자 : Ruvinsky, Ilya (검색결과 2 건)
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Ruvinsky, Ilya Princeton University 2000 해외박사(DDOD)
Two sets of paired appendages are a characteristic feature of the vertebrate body plan. Whereas the paleontological record provides a fairly accurate morphological description of limb evolution, the molecular mechanisms involved in this process are poorly understood. It is likely that the genes essential for limb development in modern vertebrates were important players during limb evolution. Two members of the T-box family of transcription factors, <italic>Tbx4</italic> and <italic> Tbx5</italic>, are prime candidates for this role since they act as determinants of fore- and hindlimb identity. In the vertebrate genome these two genes are closely linked to <italic>Tbx2</italic> and <italic>Tbx3</italic>, respectively. This arrangement most likely originated as a result of a large-scale chromosomal duplication early in vertebrate evolution. Consistent with this model, <italic> tbx2-tbx5</italic> genes in zebrafish display genomic organization and expression patterns that are remarkably similar to their tetrapod counterparts. Analysis of the T-box family in the invertebrate chordate, amphioxus, demonstrates that <italic>Tbx4</italic> and <italic>Tbx5</italic>, diverged during a relatively short time period prior to vertebrate radiation, during which a limbless chordate ancestor acquired two sets of appendages characteristic of modern vertebrates. Moreover, this divergence likely resulted from a whole genome duplication. Finally, a model, incorporating the paleontological, developmental and genetic data, is proposed to explain the evolution of paired vertebrate appendages. This model, which emphasizes the importance of gene duplication and regulatory “tinkering”, provides a conceptual framework for the understanding of evolution of serially homologous structures and thus contributes to the burgeoning field seeking to uncover the developmental and genetic bases of evolution.
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Ruvinsky, Irina The University of Chicago 2009 해외박사(DDOD)
My dissertation seeks to examine the relationship between conceptual and imaginative thought in the work of Marcel Proust in light of the philosophical tradition of German Romanticism. I propose an alternative reading of Proust's novel by establishing a new link to important philosophical foundations in the work of F. Schlegel and the German romantic tradition. By drawing on the philosophical foundations of the model of hermeneutic understanding I show that meaning for Proust is originally grounded in Erlebnis, or unmediated lived experience. It is in the light of the concept of Erlebnis that I interpret Proust's quest to preserve the insight of personal experience without sacrificing it to formal coherence, while simultaneously avoiding the romantic pitfall of giving up greater meaning for the sake of truth conceived as a species of personal revelation.
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