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RISS 인기검색어
- 검색키워드
- 저자 : Rou Jun Peng (검색결과 3 건)
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Operable Breast Cancer of the Inner Hemisphere Is Associated with Poor Survival
Cong Xue,Rou Jun Peng,Shu Sen Wang,Yan Xia Shi,Xin An,Fei Xu,Zhong Yu Yuan 한국유방암학회 2015 Journal of breast cancer Vol.18 No.1
Purpose: This study investigated the clinicopathological featuresof operable breast cancer lesions located in different hemispheresof the breast and determined related survival outcomes. Methods: Data from 5,330 patients with invasive ductal carcinomawere retrospectively analyzed based on tumor location. Results:The median follow-up time was 68 months (range, 18–176months). Patients with breast cancer located in the outer hemisphereof the breast had lesions with more advanced nodalstages and more frequently received adjuvant chemotherapythan patients with breast cancer in the inner hemisphere. The5-year disease-free survival (DFS) rates of patients with tumorslocated in outer versus inner hemispheres were 81.5% and77.0%, respectively (p=0.004); the overall survival (OS) rateswere 90.7% and 88.8%, respectively (p<0.001). The associationbetween tumor location and the 5-year DFS rate was most apparentin node-positive patients (73.1% vs. 65.8% for outer vs. inner hemisphere lesions, p<0.001) and in patients with primarytumors greater than 2 cm in diameter (78.2% vs. 72.3%,p=0.002). Multivariate analysis showed that tumor location wasan independent predictor of DFS (hazard ratio [HR], 1.23;p=0.002) and OS (HR, 1.28; p=0.006). There were no significantdifferences in 5-year DFS or OS rates between patients with outerversus inner hemisphere tumors when internal mammary nodeirradiation was performed. Conclusion: This study demonstratedthat tumor location was an independent prognostic factor foroperable breast cancer. Internal mammary node irradiation isrecommended for patients with breast cancer of the inner hemisphereand positive axillary lymph nodes or large primary tumors
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Wang, Xi,Wang, Shu-Sen,Peng, Rou-Jun,Qin, Tao,Shi, Yan-Xia,Teng, Xiao-Yu,Liu, Dong-Gen,Chen, Wei-Qing,Yuan, Zhong-Yu Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4
Purpose: This study aimed to assess possible interactive effects of coping styles and psychological stress on depression and anxiety symptoms in Chinese women shortly after diagnosis of breast cancer. Methods: Four hundred and one patients with breast cancer were face-to-face interviewed by trained research staff according to a standardized questionnaire including information on socio-demographic characteristics, psychological stress, coping styles, and anxiety and depressive symptoms. Interactive effects were assessed by hierarchical multiple regression analyses. Results: There were significant associations of the four domains of psychological stress with anxiety and depressive symptoms except for the relationship between "worrying about health being harmed" and depressive symptoms. "Abreaction coping behavior" and "escaping coping behavior" significantly increased the level of both anxiety and depressive symptoms; whereas an "active coping style" reswulted in significant decrease. The interaction of "active coping behavior" with "worrying about health being harmed" significantly increased the risk of the anxiety symptoms, while adopting "self-relaxing coping behavior" was associated with significant decrease. The interaction of "worry about daily life and social relationship being restricted" with "escaping coping behavior" significantly increased the risk of the depressive symptoms. Conclusions: The results of this study suggest that certain coping styles might moderate the association of psychological stress with anxiety and depressive symptoms in Chinese women with breast cancer.
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Gu, Wei-Guang,Huang, Yan,Yuan, Zhong-Yu,Peng, Rou-Jun,Luo, Hai-Tao,He, Zhi-Ren,Wang, Shu-Sen Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3
This study evaluated the effects of ZD1839, an orally active, selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, on nasopharyngeal carcinoma (NPC) both in vitro and in vivo. Influence of ZD1839 alone or combined with cisplatin on the NPC cell line CNE2 was detected by MTT assay with flow cytometry assessment of cell cycle distribution and apoptosis rates. Nude mice NPC xenografts were also used to evaluate the effects of ZD1839 alone or combined with cisplatin. The Student's t test evaluated statistical significance. ZD1839 alone or combined with cisplatin inhibited CNE2 cell line proliferation. ZD1839 induced CNE2 cell cycle arrest in the G1 phase, and higher concentrations induced apoptosis. Xenograft tumors were significantly smaller when treated with 200 mg/kg ZD1839, cisplatin, or cisplatin combined with 100 mg/kg ZD1839 than untreated controls. ZD1839 (200 mg/kg) alone showed good tumor inhibition effects, reduction of tumor weights, and smaller tumor volume without loss of body weight. ZD1839 (200 mg/kg) might provide a good and effective therapeutic reagent for NPC.
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