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      • KCI등재

        Sustained release coating of ibuprofen pellets at Wurster fluidization: statistical approach

        Hossein Sedighikamal,Reza Zarghami,Parissa Khadiv-Parsi,Navid Mostoufi 한국약제학회 2015 Journal of Pharmaceutical Investigation Vol.45 No.4

        The Wurster fluidization coating is recognized in many pharmaceutical industries for its precise film coating onto particulate materials such as pellets, granules, and powders. The current work focused on some process variables to study sustained release behavior of ibuprofen pellets at a lab-scale Wurster fluidized bed coater. Applying design of experiment, the effect of mean pellets size (dp), air flow rate (Qa), coating solution flow rate (Qs), and drying time duration (td) were investigated statistically on the mean dissolution time (MDT) of ibuprofen pellets. Results in analysis of variance illustrated that a decrease in dp make rising of MDT due to decreasing the ibuprofen diffusivity in the media owing to trapping role of ethyl cellulose. It was also found increasing of Qs resulted in extending of MDT due as the coating solution deposited on the pellets surface was increased. While the td did not play an important role on the MDT, the MDT was increased by Qa because of pellets circulation within the bed.

      • KCI등재

        Corms as a Source of Explants for the Successful Clonal Propagation of Crocus cancellatus

        Mahdi Ahouran,Ramin Hosseini,Reza Zarghami 한국작물학회 2012 Journal of crop science and biotechnology Vol.15 No.1

        The genus Crocus comprises plants with a potential to be developed as a new ornamental crop but to date, there are not many reports on in vitro propagation of many members of this genus. The present study involves in vitro propagation of Crocus cancella-tus with ornamental and horticultural value. Two different types of corm explants (apical and basal halves of corms) were cultivated onto Murashige and Skoog’s (MS) medium supplemented with different levels of α-naphthalene acetic acid (NAA) and 6-benzy-laminopurine (BAP). One to five cormlets emerged from every responding explant through direct organogenesis. Apical halves of corms were more highly responsive than basal halves and produced a maximum multiplication rate with 3.45 ± 0.06 cormlets per explant in 95.33 ± 2.33% of the explants in MS medium supplemented with 3% sucrose and 2 mg L -1 NAA and 1 mg L -1 BAP. The effect of cold storage temperature on in vitro cormlets sprouting was studied. Cormlets stored at 4°C for 8 weeks had more statistical-ly significant positive effects on cormlets sprouting from the controls. In vitro rooting of cormlets was induced on MS medium with-out plant hormones.

      • KCI등재

        Corms as a Source of Explants for the Successful Clonal Propagation of $Crocus$ $cancellatus$

        Ahouran, Mahdi,Hosseini, Ramin,Zarghami, Reza 한국작물학회 2012 Journal of crop science and biotechnology Vol.15 No.1

        The genus $Crocus$ comprises plants with a potential to be developed as a new ornamental crop but to date, there are not many reports on $in$ $vitro$ propagation of many members of this genus. The present study involves $in$ $vitro$ propagation of $Crocus$ $cancellatus$ with ornamental and horticultural value. Two different types of corm explants (apical and basal halves of corms) were cultivated onto Murashige and Skoog's (MS) medium supplemented with different levels of ${\alpha}$-naphthalene acetic acid (NAA) and 6-benzylaminopurine (BAP). One to five cormlets emerged from every responding explant through direct organogenesis. Apical halves of corms were more highly responsive than basal halves and produced a maximum multiplication rate with $3.45{\pm}0.06$ cormlets per explant in $95.33{\pm}2.33%$ of the explants in MS medium supplemented with 3% sucrose and $2mg\;L^{-1}$ NAA and $1mg\;L^{-1}$ BAP. The effect of cold storage temperature on in vitro cormlets sprouting was studied. Cormlets stored at $4^{\circ}C$ for 8 weeks had more statistically significant positive effects on cormlets sprouting from the controls. $In$ $vitro$ rooting of cormlets was induced on MS medium without plant hormones.

      • KCI등재

        A novel and computationally efficient algorithm for stability analysis of multi input-multi output process control systems

        Hooman Fatoorehchi,Hossein Abolghasemi,Reza Zarghami,Randolph Rach,Sebastian von Freeden 한국화학공학회 2015 Korean Journal of Chemical Engineering Vol.32 No.9

        An efficient method based on the Faddeev-Leverrier algorithm combined with the Adomian decomposition method is devised to facilitate the stability analysis of multi-input multi-output control systems. In contrast to prior eigenvalue algorithms, our method affords all eigenvalues of the state matrix, either real or complex. Specifically, the calculation of the complex eigenvalues is made possible through special canonical forms, mainly involving square root operators, of the characteristic equation of the state matrix. Moreover, the proposed method does not require an initial guess, which is often a matter of concern since an inappropriate guess can cause failure in such available schemes. For the sake of illustration, a number of numerical examples, including chemical reaction processes, are also provided that demonstrate the efficiency of our new technique.

      • KCI등재

        Conditional monitoring of moisture content in a fluidized bed dryer by the acoustic emission signature

        Farhad Karimi,Rahmat Sotudeh-Gharebagh,Reza Zarghami,Mojgan Abbasi,Navid Mostoufi 한국화학공학회 2012 Korean Journal of Chemical Engineering Vol.29 No.5

        Wetted rice particles were dried in a fluidized bed and the corresponding passive acoustic emissions signals (AES) were recorded at a given frequency to study the drying phenomena and bed hydrodynamic changes as well. The results show that the end time of the constant rate zone and the end of the falling rate can be determined from the variation of standard deviation and kurtosis of AES, respectively. Frequency domain analysis was also used to quantify the moisture content of solids. For this end, the original signal was decomposed into ten sub-signals, and it was found that the energy of the 4th sub-signal can be correlated with the moisture content. The results show that the acoustic emission measurement is applicable as a practical method for on-line condition monitoring of drying process in fluidized bed dryers.

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