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Shin, Eui-Cheol,Capone, Stefania,Cortese, Riccardo,Colloca, Stefano,Nicosia, Alfredo,Folgori, Antonella,Rehermann, Barbara American Society for Microbiology 2008 Journal of virology Vol.82 No.19
<B>ABSTRACT</B><P>Peripheral blood T-cell responses are used as biomarkers in hepatitis C virus (HCV) vaccine trials. However, it is not clear how T-cell responses in the blood correlate with those in the liver, the infection site. By studying serial liver and blood samples of five vaccinated and five mock-vaccinated control chimpanzees during acute HCV infection, we demonstrate a correlation between HCV-specific CD8 T-cell responses in the blood and molecular and functional markers of T-cell responses in the liver. Thus, HCV-specific CD8 T-cell responses in the blood are valid markers for intrahepatic T-cell activity.</P>