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RISS 인기검색어
- 검색키워드
- 저자 : Reeck, Gerald R (검색결과 3 건)
- 무료
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Nurunnabi, Md,Khatun, Zehedina,Reeck, Gerald R.,Lee, Dong Yun,Lee, Yong-kyu The Royal Society of Chemistry 2013 Chemical communications Vol.49 No.44
<P>A simple reaction process is developed to synthesize blue, green, yellow and red colour graphene nanoparticles (GNPs) from carbon fibers. Here, we have focused on synthesis of near infra-red GNPs and their biological application for optical imaging of deep tissues and organs.</P> <P>Graphic Abstract</P><P>The near infra-red (NIR) graphene nanoparticles (GNPs) have been synthesized from carbon fiber by controlling the reaction parameters. The NIR GNPs have been injected into nude mice through tail vain and tested for noninvasive optical imaging. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c3cc42334d'> </P>
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Photoluminescent Graphene Nanoparticles for Cancer Phototherapy and Imaging
Nurunnabi, Md,Khatun, Zehedina,Reeck, Gerald R.,Lee, Dong Yun,Lee, Yong-kyu American Chemical Society 2014 ACS APPLIED MATERIALS & INTERFACES Vol.6 No.15
<P>Graphene-based nanomaterials are of great interest in a wide range of applications in electronics, the environment, and energy as well as in biomedical and bioengineering. Their unique properties make them generally applicable as prognostic, diagnostic, and therapeutic agents in cancer. In this work, we focused on photodynamic and photothermal therapeutic properties of our previously synthesized carboxylated photoluminescent graphene nanodots (cGdots). The cGdots are ∼5 nm in diameter and excited at 655 nm. Our findings reveal that, upon laser irradiation by near-infrared (wavelength 670 nm) sensitizer, electrons of the cGdots starts to vibrate and form electron clouds, thereby generating sufficient heat (>50 °C) to kill the cancer cells by thermal ablation. The generation of singlet oxygen also occurs due to irradiation, thus acting similarly to pheophorbide-A, a well-known photodynamic therapeutic agent. The cGdots kills MDA-MB231 cancer cells (more than 70%) through both photodynamic and photothermal effects. The cGdots were equally effective in the <I>in vivo</I> model of MDA-MB231 xenografted tumor-bearing mice also as observed for 21 days. The cGdot was intravenously injected, and the tumor was irradiated by laser, resulting in final volume of tumor was ∼70% smaller than that of saline-treated tumor. It indicates that the growth rate of cGdot-treated tumor was slower compared to saline-treated tumor. The synthesized cGdots could enable visualization of tumor tissue in mice, thereby illustrating their use as optical imaging agents for detecting cancer noninvasively in deep tissue/organ. Collectively, our findings reveal that multimodal cGdots can be used for phototherapy, through photothermal or photodynamic effects, and for noninvasive optical imaging of deep tissues and tumors simultaneously.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2014/aamick.2014.6.issue-15/am504071z/production/images/medium/am-2014-04071z_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/am504071z'>ACS Electronic Supporting Info</A></P>
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Khatun, Zehedina,Nurunnabi, Md,Nafiujjaman, Md,Reeck, Gerald R,Khan, Haseeb A,Cho, Kwang Jae,Lee, Yong-kyu RSC Pub 2015 Nanoscale Vol.7 No.24
<P>The combined delivery of photo-and chemo-therapeutic agents is an emerging strategy to overcome drug resistance in treating cancer, and controlled light-responsive drug release is a proven tactic to produce a continuous therapeutic effect for a prolonged duration. Here, a combination of light-responsive graphene, chemo-agent doxorubicin and pH-sensitive disulfide-bond linked hyaluronic acid form a nanogel (called a graphene-doxorubicin conjugate in a hyaluronic acid nanogel) that exerts an activity with multiple effects: thermo and chemotherapeutic, real-time noninvasive imaging, and light-glutathione-responsive controlled drug release. The nanogel is mono-dispersed with an average diameter of 120 nm as observed by using TEM and a hydrodynamic size analyzer. It has excellent photo-luminescence properties and good stability in buffer and serum solutions. Graphene itself, being photoluminescent, can be considered an optical imaging contrast agent as well as a heat source when excited by laser irradiation. Thus the nanogel shows simultaneous thermo-chemotherapeutic effects on noninvasive optical imaging. We have also found that irradiation enhances the release of doxorubicin in a controlled manner. This release synergizes therapeutic activity of the nanogel in killing tumor cells. Our findings demonstrate that the graphene-doxorubicin conjugate in the hyaluronic acid nanogel is very effective in killing the human lung cancer cell line (A549) with limited toxicity in the non-cancerous cell line (MDCK).</P>
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