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RISS 인기검색어
- 검색키워드
- 저자 : Ranjita Shegokar (검색결과 4 건)
- 무료
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Nanosuspensions: a new approach for organ and cellular targeting in infectious diseases
Shegokar Ranjita 한국약제학회 2013 Journal of Pharmaceutical Investigation Vol.43 No.1
Most of the infectious diseases depending upon the stage of infection need treatment at least for a month to several years e.g. tuberculosis, acquired immunodeficiency syndrome. Medication by oral administration is of choice in all treatments, but unfortunately use of large doses resulting from drug poor solubility and bioavailability leads to toxicity. The problem of solubility should be solved in easiest way to reduce dose and to increase bioavailability thereby decreasing the unnecessary exposure of other organs than the targeted one without increasing the cost of treatment. Nanosuspensions offer a simple, easy and cost effective solution to solve all above issues, without exposing body to extra drug dose. They can also serve as industrially relevant formulation approach by overcoming problems associated with other drug delivery systems like low entrapment,polymer toxicity, biocompatibility and stability issues. In this paper, applications of nanosuspensions are discussed in detail focusing particularly treatment of infectious diseases. Furthermore, potential of them in targeting at organ, cellular and subcellular levels is debated.
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Nevirapine nanosuspensions: stability, plasma compatibility and sterilization
Ranjita Shegokar,Kamalinder K. Singh 한국약제학회 2012 Journal of Pharmaceutical Investigation Vol.42 No.5
The feasibility of preparing lyophilized or spray dried forms for reconstitution into nanosuspension (NS) was investigated in this study. The bare and surface modified aqueous NS of nevirapine were successfully converted into an anhydrous form by both techniques. The optimization of suitable cryoprotectant is essential to obtain completely dry product of desired properties. The NS adsorbed spray dried powder and granules would serve as excellent carriers for oral antiretroviral delivery. Furthermore,granules compressed to tablet showed sustained release compared to conventional marketed tablet. These results indicated that NS can be lyophilized and spray dried to prepare a product suitable for a parenteral and oral dosage form, respectively provided the formulation composition withstand phase changes during the drying processes process. Effect of sterilization method viz. steam and radiation on aqueous and lyophilized NS was also studied.
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Coenzyme Q10 oral bioavailability: effect of formulation type
Abdulwahab Barakat,Ranjita Shegokar,Michael Dittgen,Rainer H. Mu¨ ller 한국약제학회 2013 Journal of Pharmaceutical Investigation Vol.43 No.6
Coenzyme Q10 (Q10) has a poor bioavailabilitydue to its very low aqueous solubility and highmolecular weight. The purpose of this review is to discussthe different types of Q10 drug delivery systems (DDS)ranging from the simple oily dispersions to the nanotechnology-oriented systems such as nanocrystals, self-nanoemulsifieddrug delivery systems, etc. to overcome thesolubility issue. The basics of these approaches were discussedin relationship to the effect of Q10 absorption. Forthat purpose, the percentage of the drug absorbed to theblood stream out of the administered dose was calculatedas the fraction absorbed (Fa%). The Fa% for the nanoemulsionsdiscussed in this article did not correlate withdroplet size. In human studies most of the delivery systemshad a low Fa% being in the range from 1.53 to 12.48 %. The highest Fa% value was found to be for the selfemulsifieddrug delivery systems (SEDDS). In dogs studies,the Fa% values ranged between 0.28 (cyclodextrincomplex) and 4.8 %. In rat studies, some other DDS likeemulsions and solubilized formulations showed Fa% ofaround 0.22 %. The relationship between the average Fa%in rats, dogs and humans was found to be 1:15:20. Onerecent study applied both oral and intravenous delivery ofQ10; the orally tested SEDDS formulation had an absolutebioavailability of 2.2 % corresponding to Fa% = 0.04 %. The studies with Q10 formulations based only on in vitrodata were also discussed and assessed regarding the influenceof formulation on solubility, release and/or uptake.
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Expedition of liposomes to intracellular targets in solid tumors after intravenous administration
Sarandeep Malhi,Kalpana Dixit,Harmik Sohi,Ranjita Shegokar 한국약제학회 2013 Journal of Pharmaceutical Investigation Vol.43 No.2
Liposomes as a drug delivery system provides a leading approach for the systemic (intravenous) administration of drugs. Several approaches to kill tumor cells specifically have been developed, but still there is dearth in their selectivity. Among all other nano-carrier systems, liposomal formulations of cytotoxic drugs have received an appreciable recommendation in the form of clinical approvals. Liposomal delivery provides the benefits of reduced toxicity and enhanced efficacy for the treatment of cancer. However, delivery of liposomes to desired cell type with its further trafficking to desired intracellular organelle is a challenging, yet a promising approach for safer cancer therapeutics. Several anatomical-physiological barriers starting from systemic to cellular to intracellular levels are required to be overcome to achieve efficient cancer therapy. This review discusses the barriers associated with the delivery of liposomes from the extracellular to intracellular compartments of a solid tumor and further summarizes the development of liposomal carrier system to overcome these barriers.
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