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Norovirus Infection in Children with Acute Lymphoblastic Leukemia
Reddy Nalla Anuraag,Raj Keerthi,Lashkari Harsha Prasada 대한감염학회 2023 Infection and Chemotherapy Vol.55 No.3
Norovirus infection in children on treatment for acute lymphoblastic leukemia can lead to severe morbidity due to chronic viral shedding, malabsorption, failure to thrive, and interruption of chemotherapy. We had four children with norovirus diarrhoea in eight years period in our pediatric oncology unit. Three children under two years of age had chronic noroviral shedding and persistent diarrhoea, probably due to poor adaptive immune responses. Two of those children didn’t respond to nitazoxanide and succumbed to the illness. The third patient who received nitazoxanide and favipiravir, is currently well on chemotherapy.