http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Li, Hui-Yan,Ge, Xin,Huang, Guang-Ming,Li, Kai-Yu,Zhao, Jing-Quan,Yu, Xi-Miao,Bi, Wen-Si,Wang, Yu-Lin Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.7
Aim: Platinum agents have shown to be effective in the treatment of colorectal cancer. We assessed whether single nucleotide polymorphisms (SNPs) in GSTP1, ERCC1 Asn118Asn and ERCC2 Lys751Gln might predict the overall survival in patients receiving oxaliplatin-based chemotherapy in a Chinese population. Methods: SNPs of GSTP1, ERCC1 Asn118Asn and ERCC2 Lys751Gln in 335 colorectal cancer patients were assessed using TaqMan nuclease assays. Results: At the time of final analysis on Nov. 2011, the median follow-up period was 37.7 months (range from 1 to 60 months). A total of 229 patients died during follow-up. Our study showed GSTP1 Val/Val (HR=0.44, 95% CI=0.18-0.98), ERCC1 C/C (HR=0.20, 95% CI=0.10-0.79) and ERCC2 G/G (HR=0.48, 95% CI=0.19-0.97) to be significantly associated with better survival of colorectal cancer. GSTP1 Val/Val, ERCC1 C/C and ERCC2 G/G were also related to longer survival among patients with colon cancer, with HRs (95% CIs) of 0.41 (0.16-0.91), 0.16 (0.09-0.74) and 0.34 (0.16-0.91), respectively. Conclusion: GSTP1, GSTP1, ERCC1 Asn118Asn and ERCC2 Lys751Gln genotyping might facilitate tailored oxaliplatin-based chemotherapy for colorectal cancer patients.
CFD computation of ship motions and added resistance for a high speed trimaran in regular head waves
Wu, Cheng-Sheng,Zhou, De-Cai,Gao, Lei,Miao, Quan-Ming The Society of Naval Architects of Korea 2011 International Journal of Naval Architecture and Oc Vol.3 No.1
Some research work on CFD computation of ship motions and added resistance in waves for a high speed trimaran is carried out in this paper. The governing equations, Reynolds Averaged Navier-Stokes and continuity equations are discretized by finite volume method. Volume of fluid method is adopted to deal with the nonlinear free surface. The incident waves are generated from the inflow boundary by prescribing a velocity profile resembling flexible flap wavemaker motions, and the outgoing waves are dissipated inside an artificial damping zone located at the rear part of the wave tank. In this paper, the computed results of ship motion and added resistance for a high speed trimaran are presented. The results of seakeeping experiment for the high speed trimaran carried out in CSSRC towing tank are also presented in this paper. Rather good agreements are shown between the computational and experimental results. The work in this paper provides a numerical tool for the study of seakeeping performance of high speed trimarans.
CFD computation of ship motions and added resistance for a high speed trimaran in regular head waves
Cheng-sheng Wu,De-cai Zhou,Lei Gao,Quan-ming Miao 대한조선학회 2011 International Journal of Naval Architecture and Oc Vol.3 No.1
Some research work on CFD computation of ship motions and added resistance in waves for a high speed trimaran is carried out in this paper. The governing equations, Reynolds Averaged Navier-Stokes and continuity equations are discretized by finite volume method. Volume of fluid method is adopted to deal with the nonlinear free surface. The incident waves are generated from the inflow boundary by prescribing a velocity profile resembling flexible flap wavemaker motions, and the outgoing waves are dissipated inside an artificial damping zone located at the rear part of the wave tank. In this paper, the computed results of ship motion and added resistance for a high speed trimaran are presented. The results of seakeeping experiment for the high speed trimaran carried out in CSSRC towing tank are also presented in this paper. Rather good agreements are shown between the computational and experimental results. The work in this paper provides a numerical tool for the study of seakeeping performance of high speed trimarans.