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RISS 인기검색어
- 검색키워드
- 저자 : Philip Marcus (검색결과 4 건)
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Christoph G. Schuhmann,Marcus Hacker,Philip Jung,Florian Krötz,Hae-Young Sohn 대한심장학회 2014 Korean Circulation Journal Vol.44 No.1
Background and Objectives: Elevated levels of myeloperoxidase (MPO) have been found in patients in different stages of coronary artery disease (CAD). The aim of this study was to assess whether the MPO liberation is increased by stress inducible myocardial ischemia and could be used to improve the diagnostic accuracy of non-invasive evaluation for myocardial ischemia. Subjects and Methods: Seventy-six patients with suspected myocardial ischemia who underwent stress myocardial perfusion scintigraphy (MPS) were enrolled. 59 patients with an acute coronary syndrome (ACS) who received a percutaneous coronary intervention along with 12 healthy volunteers were also included in the study. In every subject the MPO plasma levels were assessed by enzyme linked immunosorbent assay. In patients undergoing MPS, the MPO levels were measured serially before and after the stress testing. Results: Of the 76 patients undergoing MPS, 38 were diagnosed with a stress inducible myocardial ischemia. The patients with a stress induced ischemia had significantly higher basal MPO levels than those without it (32±3 ng/mL vs. 24±4 ng/mL, p=0.03). However, there was no relevant change in the MPO levels after the stress test compared to the baseline. The patients with ACS showed significantly higher MPO levels than the patients undergoing MPS (131±14 ng/mL vs. 28±2 ng/mL, p<0.01) and the healthy subjects (131±14 ng/mL vs. 26±2 ng/mL, p<0.01). Conclusion: Since the MPO plasma levels did not increase after the stress MPS, MPO appears not to be a useful biomarker for detecting a stress inducible myocardial ischemia. Yet, the MPO levels correlate with the different stages of CAD and may hold significance as an indicator for its clinical severity.
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Du Bronson B.,Rezvani Sara,Bigelow Philip,Nowrouzi-Kia Behdin,Boscart Veronique M.,Yung Marcus,Yazdani Amin 한국산업안전보건공단 산업안전보건연구원 2022 Safety and health at work Vol.13 No.4
Emergency medical services (EMS) personnel are at high risk for adverse mental health outcomes during disease outbreaks. To support the development of evidence-informed mitigation strategies, we conducted a scoping review to identify the extent of research pertaining to EMS personnel's mental health during disease outbreaks and summarized key factors associated with mental health outcomes. We systematically searched three databases for articles containing keywords within three concepts: EMS personnel, disease outbreaks, and mental health. We screened and retained original peer-reviewed articles that discussed, in English, EMS personnel's mental health during disease outbreaks. Where inferential statistics were reported, the associations between individual and work-related factors and mental health outcomes were synthesized. Twenty-five articles were eligible for data extraction. Our findings suggest that many of the contributing factors for adverse mental health outcomes are related to inadequacies in fulfilling EMS personnel's basic safety and informational needs. In preparation for future disease outbreaks, resources should be prioritized toward ensuring adequate provisions of personal protective equipment and infection prevention and control training. This scoping review serves as a launching pad for further research and intervention development.
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Airfoil optimization using Design-by-Morphing
Sheikh Haris Moazam,Lee Sangjoon,Wang Jinge,Marcus Philip S 한국CDE학회 2023 Journal of computational design and engineering Vol.10 No.4
Design-by-Morphing (DbM) is a novel design methodology that creates a search space for topology optimization. Traditional design techniques often impose geometric constraints and, sometimes, the designer’s biases on the design space, which restricts the novelty of the designs and allows for only small local changes. On the contrary, we show in this paper that DbM does not impose such restrictions on the design space, thus allowing for a radical and expansive search space with only a few design parameters. We compare DbM with other methods in the case of design space generation for 2D airfoils and find that DbM can reconstruct the entire UIUC database with >99.5% accuracy. Furthermore, using a bi-objective genetic algorithm, we optimize the airfoil designs created by DbM to maximize both the lift-over-drag ratio, CLDmax, and stall angle tolerance, Δα, which results in a Pareto-front of innovative airfoils that exhibit substantial improvements in both objectives.
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