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- 저자 : Pfleger, Brian F (검색결과 1 건)
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Reassessing <i>Escherichia coli</i> as a cell factory for biofuel production
Wang, Chonglong,Pfleger, Brian F,Kim, Seon-Won Elsevier 2017 Current opinion in biotechnology Vol.45 No.-
<P>Via metabolic engineering, industrial microorganisms have the potential to convert renewable substrates into a wide range of biofuels that can address energy security and environmental challenges associated with current fossil fuels. The user-friendly bacterium, <I>Escherichia coli</I>, remains one of the most frequently used hosts for demonstrating production of biofuel candidates including alcohol-, fatty acid- and terpenoid-based biofuels. In this review, we summarize the metabolic pathways for synthesis of these biofuels and assess enabling technologies that assist in regulating biofuel synthesis pathways and rapidly assembling novel <I>E. coli</I> strains. These advances maintain <I>E. coli</I>’s position as a prominent host for developing cell factories for biofuel production.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Biofuel production has been achieved in <I>Escherichia coli</I> by construction of several metabolic pathways. </LI> <LI> The emerging technologies shows great potential in pathway engineering and stain manipulation. </LI> <LI> Tolerance engineering was required to construct an ideal biofuel producing <I>E. coli</I> host. </LI> </UL> </P>
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