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Leonardo Almeida,Daniel Martinez-Ramirez,Peter J. Rossi,Zhongxing Peng,Aysegul Gunduz,Michael S. Okun 대한신경과학회 2015 Journal of Clinical Neurology Vol.11 No.2
Tourette syndrome is a childhood-onset disorder characterized by a combination of motor andvocal tics, ofen associated with psychiatric comorbidities including attention defcit and hyperactivity disorder and obsessive-compulsive disorder. Despite an onset early in life, half of patients may present symptoms in adulthood, with variable degrees of severity. In select cases,the syndrome may lead to signifcant physical and social impairment, and a worrisome riskfor self injury. Evolving research has provided evidence supporting the idea that the pathophysiology of Tourette syndrome is directly related to a disrupted circuit involving the cortexand subcortical structures, including the basal ganglia, nucleus accumbens, and the amygdala. Tere has also been a notion that a dysfunctional group of neurons in the putamen contributes to an abnormal facilitation of competing motor responses in basal ganglia structures ultimately underpinning the generation of tics. Surgical therapies for Tourette syndrome have beenreserved for a small group of patients not responding to behavioral and pharmacological therapies, and these therapies have been directed at modulating the underlying pathophysiology. Lesion therapy as well as deep brain stimulation has been observed to suppress tics in at leastsome of these cases. In this article, we will review the clinical aspects of Tourette syndrome, aswell as the evolution of surgical approaches and we will discuss the evidence and clinical responses to deep brain stimulation in various brain targets. We will also discuss ongoing research and future directions as well as approaches for open, scheduled and closed loop feedback-driven electrical stimulation for the treatment of Tourette syndrome.