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Peng Youyuan,Zeng Xiuya,Lian Mingjian,Wang Yanfeng 대한독성 유전단백체 학회 2022 Molecular & cellular toxicology Vol.18 No.3
Background FXYD3, as a regulator of ion transporting membrane protein, plays a key role in the progression of various cancers. It is reported that FXYD3 is overexpressed in pancreatic cancer, but the molecular mechanism of FXYD3 regulating pancreatic cancer is not well illustrated. Objective The aim of this work was to study the role of FXYD3 in pancreatic cancer and the underlying mechanism. Results The expression of FXYD3 was aberrantly high in pancreatic cancer tissues and cells compared to the controls. High expression of FXYD3 was associated with the patient’s poor prognosis and promoted the proliferation, migration, and invasion of pancreatic cancer cells. Furthermore, FXYD3 expression was positively correlated with the activation of cGMP-PKG signaling pathway, and FXYD3 could enhance cGMP content. Conclusion Our study speculated that FXYD3 was likely to activate the cGMP-PKG signaling pathway to promote tumor proliferative activity. These findings contribute to understanding the role of FXYD3 in the development of pancreatic cancer and provide new therapeutic targets for its treatment.
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