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- 저자 : Pedicini, Vittorio (검색결과 2 건)
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Transarterial Therapies for Hepatocellular Carcinoma
Lanza, Ezio,Donadon, Matteo,Poretti, Dario,Pedicini, Vittorio,Tramarin, Marco,Roncalli, Massimo,Rhee, Hyungjin,Park, Young Nyun,Torzilli, Guido S. Karger AG 2017 Liver cancer Vol.6 No.1
<P><B><I>Background:</I></B> The treatment of hepatocellular carcinoma (HCC) is still a major health issue because of its increasing incidence and because of the complexity of its management. Transarterial embolization (TAE) and transarterial chemoembolization (TACE) are two widely used locoregional therapies in the treatment of HCC, especially for unresectable intermediate and advanced HCCs. <B><I>Summary: </I></B>The modern use of TAE and TACE opens new scenarios for the treatment of unresectable HCC and has yielded interesting results. The present work describes the role of transarterial therapies for HCC and focuses on the different Western and Eastern approaches to the study of response predictors. <B><I>Key Messages: </I></B>Recent refinements in interventional radiology techniques and in HCC patient selection have facilitated better local control of the disease. The molecular profiling of HCC to predict the response to TACE and TAE will greatly help clinicians identify the optimum therapy.</P>
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Vincenzo Alfieri,Giuseppe Conte,Carmen Pedicini 한국자동차공학회 2018 International journal of automotive technology Vol.19 No.3
The objective of this study is to investigate a nonlinear model-based multivariable (MIMO, Multi Input Multi Output) technique to decouple actuators interaction and to reduce the calibration effort, while increasing control performances, above all in transient conditions, and robustness with respect to model uncertainties and system parameter variations. The presented control technique is based on the development of a nonlinear dynamical physical model of the diesel air and charging system. Feedback Linearization control is then applied to decouple actuators’ interactions and compensate for nonlinearities. A new set of virtual inputs are defined inverting the system differential equations. Relation among the new virtual inputs and the outputs is purely linear and decoupled, meaning that each virtual input affects linearly only one output. Moreover, a linear control block is added to guarantee transient and steady state performances and closed loop robustness. The proposed control approach has been validated through small diesel engine dyno and vehicle activities. Transient test bench maneuvers show that the control is able to coordinate the actuators in order to fulfill the targets and to guarantee similar performances in different operating points. In addition the robustness to environmental changes has been demonstrated by vehicle tests at different ambient conditions.
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