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RISS 인기검색어
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- 저자 : Pascual-Munoz, Pablo (검색결과 2 건)
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Numerical investigation of truck aerodynamics on several classes of infrastructures
Alonso-Estebanez, Alejandro,del Coz Diaz, Juan J.,Rabanal, Felipe P.A lvarez,Pascual-Munoz, Pablo,Nieto, Paulino J. Garcia Techno-Press 2018 Wind and Structures, An International Journal (WAS Vol.26 No.1
This paper describes the effect of different testing parameters (configuration of infrastructure and truck position on road) on truck aerodynamic coefficients under cross wind conditions, by means of a numerical approach known as Large Eddy Simulation (LES). In order to estimate the air flow behaviour around both the infrastructure and the truck, the filtered continuity and momentum equations along with the Smagorinsky-Lilly model were solved. A solution for these non-linear equations was approached through the finite volume method (FVM) and using temporal and spatial discretization schemes. As for the results, the aerodynamic coefficients acting on the truck model exhibited nearly constant values regardless of the Reynolds number. The flat ground is the infrastructure where the rollover coefficient acting on the truck model showed lowest values under cross wind conditions (yaw angle of $90^{\circ}$), while the worst infrastructure studied for vehicle stability was an embankment with downward-slope on the leeward side. The position of the truck on the road and the value of embankment slope angle that minimizes the rollover coefficient were determined by successfully applying the Response Surface Methodology.
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Advances in neoadjuvant therapy for resectable pancreatic cancer over the past two decades
Alvaro Gregorio Morales Taboad,Pablo Lozano Lominchar,Lorena Martin Roman,Pilar Garcia-Alfonso,Andres Jesus Munoz Martin,Jose Antonio Blanco Rodriguez,Jose Manuel Asencio Pascual 한국간담췌외과학회 2021 Annals of hepato-biliary-pancreatic surgery Vol.25 No.2
In the last two decades, pancreatic cancer has been undergoing important changes in its perioperative management due to the great interest in multidisciplinary management and preoperative multimodal therapy, which in numerous studies have shown promising clinical results. Although the standard of treatment for resectable pancreatic ductal adenocarcinoma (PDAC) today is surgery followed by adjuvant therapy, as it is a biologically aggressive disease, even with complete resection, it has high rates of local and distant relapse. Several retrospective and prospective phase I/II studies have opened the window for neoadjuvant therapy with chemotherapy (CT), chemoradiotherapy (CRT), or both, as an alternative treatment for resectable pancreatic cancer, with promising results. Neoadjuvant therapy could has some advantages, including early administration of systemic treatment, in vivo assessment of response to treatment, increase resectability rate in borderline patients, increase resection rate with negative margin and survival benefit. While it seems clear that even potentially resectable disease would benefit from preoperative multimodal therapy, the optimal neoadjuvant therapeutic strategy is still controversial and currently there are only recommendations for neoadjuvant treatment, in clinical guidelines such as the NCCN and ESMO, for borderline and/or locally advanced PDAC. This review provides an overview of recent studies available and how they relate to systemic treatment of resectable PDAC in the neoadjuvant setting.
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