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        Risk Factors for Breast Cancer in Iranian Women: A Hospital-Based Case-Control Study in Tabriz, Iran

        Mina Hosseinzadeh,Jamal Eivazi Ziaei,Nader Mahdavi,Parvaneh Aghajari,Maryam Vahidi,Alaviehe Fateh,Elnaz Asghari 한국유방암학회 2014 Journal of breast cancer Vol.17 No.3

        Purpose: Breast cancer is the most common cancer in womenworldwide and the leading cause of cancer death among women. In Asian countries such as Iran, the incidence of breast canceris increasing. The present study aimed to assess the riskfactors for breast cancer of women in Tabriz, Iran. Methods: Ahospital-based case-control study was undertaken to identifybreast cancer risk factors. The study consisted of 140 casesconfirmed via histopathological analysis and 280 group-matchedcontrols without any malignancy. Data were analyzed using descriptiveand inferential statistical methods via the SPSS softwareversion 18. Results: In a multivariate analysis, educationallevel (odds ratio [OR], 4.7; 95% confidence interval [CI], 2.11–10.83), menopausal status (OR, 2.54; 95% CI, 1.41–4.59), ahigh-fat diet (OR, 2.76; 95% CI, 1.51–5.04), abortion (OR, 2.13;95% CI, 1.20–3.79), passive smoking (OR, 2.76; 95% CI, 1.51–5.04), oral contraceptive use (OR, 3.18; 95% CI, 1.80–5.59),stress (OR, 3.05; 95% CI, 1.74–5.36), and migration (OR, 3.09;95% CI, 1.39–6.90) were factors associated with a significantlyincreased risk of breast cancer. Breastfeeding (OR, 0.39; 95%CI, 0.16–0.97) and a diet containing sufficient fruit and vegetables(OR, 0.22; 95% CI, 0.12–0.39) had protective roles againstbreast cancer. Conclusion: The study revealed that the risk factorsfor breast cancer among women in the Tabriz area of Iranare related to the lifestyle. Therefore, the provision of educationto change unhealthy lifestyle choices and periodic check-ups forearly breast cancer detection are recommended.

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