Design optimization of semi-rigid space steel frames with semi-rigid bases using biogeography-based optimization and genetic algorithms

Osman Shallan,Hassan M. Maaly,Merve Sagiroglu,Osman Hamdy 국제구조공학회 2019 Structural Engineering and Mechanics, An Int'l Jou Vol.70 No.2

This paper performs for the first time a simultaneous optimization for members sections along with semi-rigid beam-to-column connections for space steel frames with fixed, semi-rigid, and hinged bases using a biogeography-based optimization algorithm (BBO) and a genetic algorithm (GA). Furthermore, a member’s sections optimization for a fully fixed space frame is carried out. A real and accurate simulation of semi-rigid connection behavior is considered in this study, where the semi-rigid base connections are simulated using Kanvinde and Grilli (2012) nonlinear model, which considers deformations in different base connection components under the applied loads, while beam-to-column connections are modeled using the familiar Frye and Morris (1975) nonlinear polynomial model. Moreover, the P-∆ effect and geometric nonlinearity are considered. AISC-LRFD (2016) specification constraints of the stress and displacement are considered as well as section size fitting constraints. The optimization is applied to two benchmark space frame examples to inspect the effect of semi-rigidity on frame weight and drift using BBO and GA algorithms.

A developed design optimization model for semi-rigid steel frames using teaching-learning-based optimization and genetic algorithms

Osman Shallan,Hassan M. Maaly,Osman Hamdy 국제구조공학회 2018 Structural Engineering and Mechanics, An Int'l Jou Vol.66 No.2

This paper proposes a developed optimization model for steel frames with semi-rigid beam-to-column connections and fixed bases using teaching-learning-based optimization (TLBO) and genetic algorithm (GA) techniques. This method uses rotational deformations of frame members ends as an optimization variable to simultaneously obtain the optimum cross-sections and the most suitable beam-to-column connection type. The total cost of members plus connections cost of the frame are minimized. Frye and Morris (1975) polynomial model is used for modeling nonlinearity of semi-rigid connections, and the P-∆ effect and geometric nonlinearity are considered through a stepped analysis process. The stress and displacement constraints of AISC-LRFD (2016) specifications, along with size fitting constraints, are considered in the design procedure. The developed model is applied to three benchmark steel frames, and the results are compared with previous literature results. The comparisons show that developed model using both LTBO and GA achieves better results than previous approaches in the literature.

A developed design optimization model for semi-rigid steel frames using teaching-learning-based optimization and genetic algorithms

Shallan, Osman,Maaly, Hassan M.,Hamdy, Osman Techno-Press 2018 Structural Engineering and Mechanics, An Int'l Jou Vol.66 No.2

This paper proposes a developed optimization model for steel frames with semi-rigid beam-to-column connections and fixed bases using teaching-learning-based optimization (TLBO) and genetic algorithm (GA) techniques. This method uses rotational deformations of frame members ends as an optimization variable to simultaneously obtain the optimum cross-sections and the most suitable beam-to-column connection type. The total cost of members plus connections cost of the frame are minimized. Frye and Morris (1975) polynomial model is used for modeling nonlinearity of semi-rigid connections, and the $P-{\Delta}$ effect and geometric nonlinearity are considered through a stepped analysis process. The stress and displacement constraints of AISC-LRFD (2016) specifications, along with size fitting constraints, are considered in the design procedure. The developed model is applied to three benchmark steel frames, and the results are compared with previous literature results. The comparisons show that developed model using both LTBO and GA achieves better results than previous approaches in the literature.

Evaluation of the Atlas Helicobacter pylori Stool Antigen Test for Diagnosis of Infection in Adult Patients

Osman, Hussein Ali,Hasan, Habsah,Suppian, Rapeah,Bahar, Norhaniza,Che Hussin, Nurzam Suhaila,Rahim, Amry Abdul,Hassan, Syed,Andee, Dzulkarnaen Zakaria,Zilfalil, Bin-Alwi Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.13

Background: Helicobacter pylori (H.pylori) is one of the most important causes of dyspepsia and gastric cancer and diagnosis can be made by invasive or non-invasive methods. The Atlas Helicobacter pylori antigen test is a new rapid non-invasive method which is simple to conduct. The aim of this study was to determine its sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy. Materials and Methods: This prospective study was conducted between July 2012 and December 2013. Stool samples of 59 dyspeptic patients who underwent upper endoscopy were evaluated for H. pylori stool antigen. Results: From the 59 patients who participated in this study, there were 36 (61%) males and 23 (39%) females. H. pylori was diagnosed in 24 (40.7%) gastric biopsies, 22 (91.7 %) of these being positive for the Atlas H. pylori antigen test. The sensitivity, specificity, PPV, NPV and accuracy were 91.7%, 100%, 100%, 94.6% and 96.6% respectively. Conclusions: The Atlas H. pylori antigen test is a new non-invasive method which is simple to perform and avails reliable results in a few minutes. Thus it can be the best option for the diagnosis of H. pylori infection due to its high sensitivity and specificity.

In-vitro release and in-vivo performance of tolmetin from different topical gel formulations

Sayed Hassan Auda,Saleh Abd El-Rasoul,Mahmoud Mohamed Ahmed,Shaaban Khalaf Osman,Mahmoud El-Badry 한국약제학회 2015 Journal of Pharmaceutical Investigation Vol.45 No.3

This study was designed to evaluate the suitability of Pluronic F-127, different grades of Carbopol and cellulosic polymers as gel bases containing tolmetin, a nonsteroidal anti-inflammatory drug. In vitro release characteristics, effect of enhancers, viscosity and the mechanism of drug release for different gel bases was studied as well as the anti-inflammatory activity were evaluated. The results showed that the HPMC gel has the superior percent of drug release than the others. The percent released of drug from Carbopol and the Pluronic F-127 gels is concentration defendants. It was found that the drug release from the tested gel bases obeyed the diffusion mechanism. The use of propylene glycol and urea in different concentrations (3.0, 5.0 and 10 % w/v) had enhanced the percent of drug release significantly (p<0.05). The anti-inflammatory activity of the drug in Carbopol gel formulation showed excellent anti-inflammatory activity. These finding highlight the potential local application of tolmetin gel as topical anti-inflammatory medication.

In vivo effects of different anesthetic agents on apoptosis

Emad S. Osman,Hanan F. Khafagy,,Yasser M. Samhan,Mona M. Hassan,Faten M. El-Shanawany,Abdel Rahman M. Fathallah,Gehan G. El-fandy 대한마취통증의학회 2012 Korean Journal of Anesthesiology Vol.63 No.1

Background: This study was designed to measure in vivo effects of propofol, isoflurane and sevoflurane on apoptosis by measuring caspase-3 and tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL) blood level as apoptotic markers. Methods: After obtaining ethical committee approval and informed written consents, sixty adult patients ASA I scheduled for open cholecystectomy participated in this study. They were randomally allocated into one of three equal groups to receive propofol infusion, low-flow isoflurane or sevoflurane for maintenance of anesthesia. Venous blood samples were collected preoperatively, immediately postoperative and after 24 hours to measure hemoglobin,hematocrit, creatinine, liver enzymes, serum TRAIL and caspase-3 levels. Results: There was no significant difference in hematological markers and serum creatinine. Liver enzymes showed significant postoperative rise (P < 0.05). In Propofol group, TRAIL and caspase-3 levels were significantly elevated immediately postoperative then decreased significantly after 24-hours (P < 0.05). In Isoflurane group, immediate postoperative level of TRAIL was significantly higher than 24 hours reading and significantly lower than its level in Propofol group at the same timing meanwhile caspase-3 levels were comparable at different timings. In Sevoflurane group, TRAIL and caspase-3 levels increased significantly in both postoperative samples than preoperative level and than those of Isoflurane and Propofol groups after 24 hours concerning TRAIL (P < 0.05). Conclusions: This study concluded that isoflurane is superior and sevoflurane is the least effective among the three anesthetics in protection against apoptosis. This study neither proved nor excluded propofol-induced apoptosis. Further studies are required during lengthy procedure and in compromised patients. Background: This study was designed to measure in vivo effects of propofol, isoflurane and sevoflurane on apoptosis by measuring caspase-3 and tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL) blood level as apoptotic markers. Methods: After obtaining ethical committee approval and informed written consents, sixty adult patients ASA I scheduled for open cholecystectomy participated in this study. They were randomally allocated into one of three equal groups to receive propofol infusion, low-flow isoflurane or sevoflurane for maintenance of anesthesia. Venous blood samples were collected preoperatively, immediately postoperative and after 24 hours to measure hemoglobin,hematocrit, creatinine, liver enzymes, serum TRAIL and caspase-3 levels. Results: There was no significant difference in hematological markers and serum creatinine. Liver enzymes showed significant postoperative rise (P < 0.05). In Propofol group, TRAIL and caspase-3 levels were significantly elevated immediately postoperative then decreased significantly after 24-hours (P < 0.05). In Isoflurane group, immediate postoperative level of TRAIL was significantly higher than 24 hours reading and significantly lower than its level in Propofol group at the same timing meanwhile caspase-3 levels were comparable at different timings. In Sevoflurane group, TRAIL and caspase-3 levels increased significantly in both postoperative samples than preoperative level and than those of Isoflurane and Propofol groups after 24 hours concerning TRAIL (P < 0.05). Conclusions: This study concluded that isoflurane is superior and sevoflurane is the least effective among the three anesthetics in protection against apoptosis. This study neither proved nor excluded propofol-induced apoptosis. Further studies are required during lengthy procedure and in compromised patients.

Liver Cancer Stem Cell Induction from Induced Pluripotent Stem Cells

( Said M Afify ),( Ghmkin Hassan ),( Hend M Nawara ),( Hager M Mansour ),( Amira Osman ),( Sadia Monzur ),( Hagar Ali Abu Quora ),( Maram H Zahra ),( Akimasa Seno ),( Yoshiaki Iwasaki ),( Masaharu Sen 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1

Aims: Liver cancer stem cells represent a small fraction of cells in liver cancer tissues so that studying these cells is very hard. Generation of liver cancer stem cells considered as one of the most important issue in cancer biology research. For this reason, we tried to generate liver cancer stem cells from induced pluripotent stem (iPSCs). Methods: First of all, CM was collected from confluent culture of Huh7 cells. Then, mouse iPSCs cells without MEF feeder cells were cultured in the presence of 50% CM for 4 weeks. The medium was changed every day with fresh medium containing 50% of CM. Mouse iPSCs cultured is the complete medium with LIF were used as a control. The survived cells (5x105 cells) were suspended in HBSS and injected into the liver of BALB/ c nude mice. After 25 days malignant tumor was formed in the liver while benign teratoma was formed by the injection of iPSCs. Tumors were then excised and partly fixed in 10% neutral formalin buffer solution for HE staining and immunohistochemical analysis. The rest of tumors were subjected to rt-qPCR anaylsis and primary culture. Results: Immunohistochemical analysis with liver cancer associated markers and cancer stem cell marker showed that malignant liver tumor was developed. These results indicate that the primary cells from the malignant tumor are rich in CSCs. Conclusions: This model will be very important and useful to assess the significant molecular mechanisms necessary to maintain liver cancer stem cells, which will help in defat liver cancer.

Response of Triple Negative Breast Cancer to Neoadjuvant Chemotherapy: Correlation between Ki-67 Expression and Pathological Response

Elnemr, Gamal M,El-Rashidy, Ahmed H,Osman, Ahmed H,Issa, Lotfi F,Abbas, Osama A,Al-Zahrani, Abdullah S,El-Seman, Sheriff M,Mohammed, Amrallah A,Hassan, Abdelghani A Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.2

Triple-negative breast cancers constitute about 15% of all cases, but despite their higher response to neoadjuvant chemotherapy, the tumors are very aggressive and associated with a poor prognosis as well as a higher risk of early recurrence. This study was retrospectively performed on 101 patients with stage II and III invasive breast cancer who received 6-8 cycles of neo-adjuvant chemotherapy. Out of the total, 23 were in the triple negative breast cancer subgroup. Nuclear Ki-67 expression in both the large cohort group (n=101) and triple negative breast cancer subgroup (n=23) and its relation to the pathological response were evaluated. The purpose of the study was to identify the predictive value of nuclear protein Ki-67 expression among patients with invasive breast cancers, involving the triple negative breast cancer subgroup, treated with neoadjuvant chemotherapy in correlation to the rate of pathological complete response. The proliferation marker Ki-67 expression was highest in the triple negative breast cancer subgroup. No appreciable difference in the rate of Ki-67 expression in triple negative breast cancer subgroup using either a cutoff of 14% or 35%. Triple negative breast cancer subgroup showed lower rates of pathological complete response. Achievement of pathological complete response was significantly correlated with smaller tumor size and higher Ki-67 expression. The majority of triple negative breast cancer cases achieved pathological partial response. The study concluded that Ki-67 is a useful tool to predict chemosensitivity in the setting of neoadjuvant chemotherapy for invasive breast cancer but not for the triple negative breast cancer subgroup.

Strength and Weakness of Software Risk Assessment Tools

Abdullahi Mohamud Sharif,Shuib Basri,Hassan Osman Ali 보안공학연구지원센터 2014 International Journal of Software Engineering and Vol.8 No.3

Theoretical rotational stiffness of the flexible base connection based on parametric study via the whale optimization algorithm

Mahmoud T. Nawar,Ehab B. Matar,Hassan M. Maaly,Ahmed G. Alaaser,Osman Hamdy 국제구조공학회 2023 Structural Engineering and Mechanics, An Int'l Jou Vol.88 No.1

This paper handles the results of an extensive parametric study on the rotational stiffness of the flexible base connection using ABAQUS program. The results of the parametric study show the relation between the applied moment and the relative rotation for 96 different base connections. The configurations of the studied connections considered different numbers, diameters, and spacing of the anchor bolts along with different thicknesses of the base plate to investigate the effect of these parameters on the rotational stiffness behavior. The results of the previous parametric research used through the whale optimization algorithm (WOA) to detect different equation formulation of the moment-rotation (M-Ɵr) equation to detect optimum equation simulates the general nonlinear rotational behavior of the flexible base connection considering all variables used in the parametric study. WOA is a relatively new promising algorithm, which is used in different types of optimization problems. For more verification, the classical genetic algorithm (GA) is used to make a comparison with WOA results. The results show that WOA is capable of getting an optimum equation of the M-Ɵr relation, which can be used to simulate the actual rotational stiffness of the flexible base connections. The rotational stiffness at H/150 can be calculated using WOA (1) method and be used as a design aid for engineering design.