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        Chromosomal Variations in Patients with Bipolar Affective Disorder

        Osman Dermirhan,Deniz Ta?temir,Nurg?l ?zpoyraz 한국유전학회 2007 Genes & Genomics Vol.29 No.1

        The study of cytogenetic abnormalities may lead to a more accurate localization of genes related to disease. Therefore, chromosome determination could be included among the routine investigations of patients with bipolar disorder. We have examined the chromosomes of 80 banding technique. Random numerical and structural variations were present in 26.3% of the patients and in 10% of the controls. Of these, 57.1% and 42.9% of abnormalities had structural and numerical aberrations, respectively. Structural aberations usually consisted of deletions, heterochromatic regions of chromosome 9, and partial trisomy of various chromosomes. Numerical chro-trisomy 21, monosomy X, 47,XY, marker, and acentric chromosomes. The frequency of sex chromosome changes in our populations (3.75%) was significantly increased compared to t h a t i n n e w b o r n s . T h e s e regions can be the most active hotspots in the genomes of bipolar patients. The identification of such chromosomal abnormalities asociated with bipolar disorder could provide important e(s) on the chromosome(s).

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