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      • KCI등재

        Effect of wavy wall strut fuel injector on shock wave development and mixing enhancement of fuel and air for a scramjet combustor

        Obula Reddy Kummitha,K.M. Pandey 한국CDE학회 2021 Journal of computational design and engineering Vol.8 No.1

        The shear mixing and streamline vortices are the notable parameters to influence the air–fuel mixing in hypersonic flows. The shock wave development and Mach number significantly influence the shear mixing phenomenon. Hence, this research introduced an unconventional strut and tested its performance for the generation of shock waves at different flow conditions (M = 2,4,6). The Reynolds-averaged Navier–Stokes equations are solved to evaluate the performance of the new strut. Both the DLR scramjet strut injector and wavy wall strut injector are assessed for the shear mixing development. Turbulence for the association of shock waves, mixing layer, and the boundary layer has been modeled with the SST k-ω model. The variation in shock development and its interactions are investigated further with an increase in Mach number. The scramjet flow structure differentiation found the increased number of oblique shock waves with the wavy wall strut fuel injector. It increases the turbulence level with increased streamline vortices, turbulent intensity, and turbulent kinetic energy. The shock wave generation analysis at different Mach numbers (M = 2,4,6) found fewer interactions between the shock wave and shear layer with increased Mach number. From the examination of shock wave generation and its interaction with the shear layer and analysis of turbulent parameters, it is found that the wavy wall strut has an appreciable effect on shock-induced blend augmentation of fuel and air.

      • KCI등재

        CFD analysis for airflow distribution of a conventional building plan for different wind directions

        Obula Reddy Kummitha,R. Vijay Kumar,V. Murali Krishna 한국CDE학회 2021 Journal of computational design and engineering Vol.8 No.2

        Computational fluid dynamics analysis of a building plan has been investigated with predominant wind velocity for different wind directions. The flow properties’ variation in the computational domain has been modeled by solving the Reynolds-Averaged Navier–Stokes (RANS) equations with the finite volume second-order discretization scheme. The turbulence of airflow distribution in and around the building has been modeled with the Shear Stress Transport (SST) k–ω turbulence model from the analysis of different turbulence models. Numerical results are analysed by evaluating and comparing the various flow properties at different building plan locations with different wind directions. The development of pressure coefficients, wind-driven driving force, and air change per hour are studied for different wind directions. From the analysis of numerical results, it is identified that better ventilation with sufficient airflow distribution has existed when the wind is coming from the west direction.

      • KCI등재

        Computational investigation of heat energy interaction for a residential building with a normal clay brick and sinicon brick

        Obula Reddy Kummitha,R. Vijay Kumar 한국CDE학회 2021 Journal of computational design and engineering Vol.8 No.2

        Most of the building energy is mainly contributing to the achievement of thermal comfort. The cooling load on air conditioners will increase with increased heat transfer into the building from the surroundings. The amount of heat transfer into the building mainly depends on building materials used in construction. In this research, an attempt has been made to analyse the self-sufficient homes’ concept by visualizing variation in heat transfer of the building concerning ordinary clay brick and brick with sinicon composition. The temperature distribution of airflow, time lag, decrement factor, and comfort conditions are investigated concerning these materials with computational fluid dynamics. Numerical modeling has been defined by selecting three-dimensional fluid flow governing equations and the k–ε turbulence model. All the fluid flow governing equations have been solved with the finite-volume second-order upwind discretization and SIMPLE algorithm for pressure–velocity coupling. Numerical results have been analysed for both the materials and we identified that the sinicon brick material for the considered wall thickness (9 inches) had registered an increased time lag (∼2 hrs) and a decreased decrement factor (0.05). This research investigation shows that the sinicon-brick wall strongly decreases heat transfer through it compared to the normal-red brick wall. The sinicon brick significantly reduces the air conditioner’s cooling load by decreasing heat energy penetration into the building.

      • Elevated Serum Haptoglobin is Associated with Clinical Outcome in Triple-Negative Breast Cancer Patients

        Tabassum, Umaira,Reddy, Obula,Mukherjee, Geetashree Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.9

        Background: Breast cancer is the most common malignancy with the highest incidence rates among women worldwide. Triple-negative breast cancer (TNBC) disease is diagnosed more frequently in younger women, and is associated with a poor prognosis. Elevated levels of serum haptoglobin protein (Hp) are observed in many malignant diseases including breast cancer. We evaluated the expression and prognostic value of Hp among patients with TNBC. Materials and Methods: Serum Hp levels were determined by Elisa in 41 patients with TNBC and 10 normal individuals. Hp status was correlated with other clinico-pathological parameters including patient survival. Results: Of the 41 patients with TNBC, Hp over expression was detected in 24 (59%) by Elisa. Hp up-regulation was confirmed by Elisa based quantification in the serum of 41 TNBC patients against lower grades and 10 normal individuals. Survival analysis revealed that Hp ($p=2.016{\times}10^{-5}$), stage ($p=2.166{\times}10^{-5}$), distant metastasis ($p=2.217{\times}10^{-5}$), tumor size ($p=1.053{\times}10^{-5}$), and tumor grade (p=0.001), correlated with patient survival on univariate analysis. Multivariate analysis revealed that Hp (p=0.001), and grade of the disease (p=0.008) were independent predictors of survival. Conclusion: Our results indicate that serum levels of Hp may play a role as a potential serum biomarker and prognostic indicator among TNBC patients. Thus, Hp may present a new promising prognostic biomarker in TNBC patients, but independent validations are now necessary for confirmation.

      • SCOPUSKCI등재

        Montmorillonite Clay Catalyzed Three Component, One-Pot Synthesis of 5-Hydroxyindole Derivatives

        Reddy, B.V. Subba,Reddy, P. Sivaramakrishna,Reddy, Y. Jayasudhan,Bhaskar, N.,Reddy, B. Chandra Obula Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.10

        A highly efficient and environmentally benign protocol has been developed for the first time to produce a wide range of biologically active 5-hydroxyindole derivatives using montmorillonite KSF clay as a reusable solid acid catalyst. The use of recyclable clay makes this procedure quite simple, more convenient and cost-effective.

      • KCI등재

        Montmorillonite Clay Catalyzed Three Component, One-Pot Synthesis of 5-Hydroxyindole Derivatives

        B. V. Subba Reddy,P. Sivaramakrishna Reddy,Y. Jayasudhan Reddy,N. Bhaskar,B. Chandra Obula Reddy 대한화학회 2013 Bulletin of the Korean Chemical Society Vol.34 No.10

        A highly efficient and environmentally benign protocol has been developed for the first time to produce a wide range of biologically active 5-hydroxyindole derivatives using montmorillonite KSF clay as a reusable solid acid catalyst. The use of recyclable clay makes this procedure quite simple, more convenient and cost-effective.

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