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Diels-Alder Type Adducts from Hairy Root Cultures of Morus macroura
Nizar Happyana,Euis H. Hakim,Yana M. Syah,Oliver Kayser,Lia D. Juliawaty,Didin Mujahidin,Tri M. Ermayanti,Sjamsul A. Achmad 한국생약학회 2019 Natural Product Sciences Vol.25 No.3
Three Diels-Alder type adducts, guangsangon E (1), chalcomoracin (2) and sorocein I (3) were isolated from hairy root cultures of Morus macroura. The structures of the isolated compounds (1 - 3) were determined by spectroscopic method (NMR and MS), and spectral comparison to literature. Cytotoxic activities of the isolated compounds (1 - 3) were investigated against P-388 murine leukemia cell line. Guangsangon E (1) showed the most potent cytotoxicity against P-388 murine leukemia cell line with IC50 value of 2.75 ± 0.32 µg/mL. To the best of our knowledge, guangsangon E (1) and sorocein I (3) were reported for the first time from the tissue cultures of M. macroura.