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RISS 인기검색어
- 검색키워드
- 저자 : Nguyen Thi Thu Hang (검색결과 3 건)
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All-trans retinoic acid-induced Carboxypeptidase D secretion of Human monocytic THP-1
Nguyen Thi Thu Hang Gachon University, Graduate School 2018 국내석사
Carboxypeptidase D (CPD) is a metallocarboxypeptidase, which cleaves C terminal arginine or lysine residue from peptides using a zinc ion in its active site. In this study, we examined the effect of all-trans retinoic acid (ATRA) on CPD expression and secretion of the human monocytic THP-1 cell line. CPD mRNA expression was examined by quantitative real-time PCR. CPD expression was significantly enhanced by various concentrations of ATRA. This enhanced expression was found to depend on RAR/RXR pathway. Since CPD is known to mainly express on cell membrane, cell surface CPD expression was measured by flow cytometry. Despite a significant increase in mRNA expression, cell surface CPD expression was not changed by ATRA treatment. To find reason for mRNA and2 protein expression discrepancy, we measured secreted CPD protein in the culture supernatant by western blot analysis. CPD secretion was significantly enhanced by ATRA treatment in time and concentrationdependent manners. This enhanced CPD secretion was not dependent on RAR/RXR pathway. ATRA-induced CPD secretion was reversed by pre-treatment of dexamethasone, anti-inflammatory drug. To find a candidate substrate of secreted CPD, purified bradykinin, an inflammatory mediator, was subjected to concentrated culture supernatants from ATRA-treated cells, and possible cleavage of bradykinin was measured by HPLC. Bradykinin specific peak was diminished by treatment with concentrated culture supernatants from ATRA-treated cells. This diminished bradykinin peak was partly reversed by dexamethasone treatment. Since desarg9-bradykinin is known to bind bradykinin B1 receptor and to induce inflammatory responses, bradykinin B1 receptor mRNA expression of THP-1 cells was examined. Bradykinin B1 receptor mRNA expression of ATRA treated cells was up-regulated in time and concentration-dependent manners. In conclusion, our results demonstrate that ATRA enhances CPD expression and secretion of human monocytic THP-1 cells, and suggest possible involvement of ATRA-induced secreted CPD in bradykinin cleavage to produce truncated version of bradykinin, another potent inflammatory mediator.
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Real time H.264/AVC video encoder on mobile environment using ARM-DSP co-processor
Nguyen, Thi Thu Hang 건국대학교 대학원 2011 국내석사
H.264/AVC는 신기술 개발에 관련이 있는 비디오 압축 표준이다. 또한 이는 이전의 비디오 압축 표준에 비해 계산 복잡도가 크다는 것을 의미한다. 성능이 좋은 프로세서나 멀티 프로세서는 업계에서H.264/AVC 표준을 기반으로 한 실시간 응용프로그램을 만족시킬 수 있어서 점점 더 많이 쓰이고 있다. 본 논문에서는 최신의 비디오 코덱인 H.264를 소개한다. 또한 H.264의 구현 및 모바일 환경에서의 최적화에 대해 논의한다. H.264 Baseline Profile 인코더는 강력한 ARM 코어와 DSP 코어를 가진 멀티 코어 임베디드 프로세서로 구성된 ARM-DSP 프로세서 보드로 구현하였다. 최적화된 H.264 인코더는 병렬 모델과 코딩 최적화를 통해서 PSNR의 최소한 저하되면서 코딩 속도를 실시간으로 할 수 있으며, bit-rate가 조금 더 나아져서 성능이 향상을 이룩하였다. 실험 결과는 EVM3530보드에서 최적화된 H.264로 QCIF(176x144)해상도를 실시간(초당 24 프레임 이상)으로 인코딩 할 수 있음을 보여준다. H.264/AVC is the latest video compression standard with a number of relatively new technical developments. It also means that the computation complexity compared to the previous video compression standards is increased. Either powerful processors or multi-processors are more and more popular in the commercial industry to meet requirement of real-time applications based on H.264/AVC standard. In this paper, the latest generation video coding standard H.264 is introduced. Also, implementation and optimization of H.264 encoder on Mobile Environment are discussed. H.264 Baseline Profile encoder is implemented on ARM-DSP processor board which has a multi-core powerful embedded processor, including ARM core and DSP core. The H.264 encoder is improved to reach real-time in terms of coding speed with a little performance degradation in term of PSNR and a little better performance of bit-rate by using parallel model and coding optimization. Experimental results show that the speed of optimized H.264 encoder increases to reach real-time (more than 24 frames per second) with QCIF (176x144) resolution on EVM3530 board.
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