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- 저자 : Nermin Bayar (검색결과 4 건)
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ASSESSMENT OF AORTIC ELASTICITY PROPERTIES IN PATIENTS WITH CELIAC DISEASE
Nermin Bayar,Ayhan Hilmi Çekin,Şakir Arslan,Göksel Çağırcı,Selçuk Küçükseymen,Serkan Çay,Ferda Akbay Harmandar,Bayram Yeşil 대한심장학회 2016 Korean Circulation Journal Vol.46 No.2
Background and Objectives Celiac disease (CD) is a chronic autoimmune disorder induced by dietary gluten intake by individuals who are genetically sensitive. Many studies report an increased risk of cardiovascular diseases in such patients. The aim of this study is to assess aortic elasticity properties in patients with CD that may be associated with an increased risk of cardiovascular disease. Subjects and Methods Eighty-one patients diagnosed with CD by antibody test and biopsy and 63 healthy volunteers were included in this prospective study. Electrocardiographic and echocardiographic examinations were performed. Results The CD group did not have any differences in the conventional echocardiographic parameters compared to the healthy individuals. However, patients in the CD group had an increased aortic stiffness beta index (4.3±2.3 vs. 3.6±1.6, p=0.010), increased pressure strain elastic modulus (33.6±17.0 kPa vs. 28.5±16.7 kPa, p=0.037), decreased aortic distensibility (7.0±3.0×10-6 cm2/dyn vs. 8.2±3.6×10-6 cm2/dyn, p=0.037), and similar aortic strain (17.9±7.7 vs. 16.0±5.5, p=0.070) compared to the control group. Patients with CD were found to have an elevated neutrophil/lymphocyte ratio compared to the control group (2.54±0.63 vs. 2.24±0.63, p=0.012). However, gluten-free diet and neutrophil/lymphocyte ratio were not found to be associated with aortic elasticity. Conclusion Patients with CD had increased aortic stiffness and decreased aortic distensibility. Gluten-free diet enabled the patients with CD to have a reduction in the inflammatory parameters whereas the absence of a significant difference in the elastic properties of the aorta may suggest that the risk of cardiovascular disease persists in this patient group despite a gluten-free diet.
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The Relationship between Spontaneous Multi-Vessel Coronary Artery Dissection and Celiac Disease
Nermin Bayar,Göksel Cagırcı,Cagın Mustafa Üreyen,Görkem Kus,Selcuk Kücükseymen,Sakir Arslan 대한심장학회 2015 Korean Circulation Journal Vol.45 No.3
Celiac disease (CD) is an immune-mediated enteropathy involving the small intestines. Genetic and environmental risk factors as well as autoimmunity have been linked to its etiology. Studies have shown that coronary artery disease, autoimmune myocarditis, arrhythmias and premature atherosclerosis are more prevalent in individuals with CD compared to individuals without the disease. In this case report a young male patient with CD presented with acute myocardial infarction with spontaneous coronary artery dissections of two vessels. To the best of our knowledge, this is the first case report of spontaneous multi-vessel coronary artery dissection in a patient with CD.
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Isa Oner Yuksel,Sakir Arslan,Nermin Bayar,Selcuk Kucukseymen,Erkan Koklu,Bekir Erol 대한심장학회 2014 Korean Circulation Journal Vol.44 No.2
Anomalous origin of coronary arteries is generally asymptomatic and a rare disease. However, some cases can cause severe life-threateningevents such as myocardial ischemia, arrhythmia, and acute myocardial infarction. We describe a case of a single coronary artery arisingfrom the right sinus of Valsalva in a 48-year-old female patient with a complaint of stable angina pectoris and palpitations. Coronary an-giography revealed that all three coronary arteries arose from the right sinus. Coronary CT angiography confirmed that there was ananomalous origin of the left coronary artery arising from the right sinus of Valsalva. The patient was managed with conservative treatment.
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Goksel Cagirci,Selcuk Kucukseymen,Isa Oner Yuksel,Nermin Bayar,Erkan Koklu,Ramazan Guven,Sakir Arslan 대한심장학회 2017 Korean Circulation Journal Vol.47 No.2
Background and Objectives: Vitamin D is generally known to be closely related to inflammation. The effects of vitamin D on coronary artery disease (CAD) are not fully explained. Nowadays, coronary artery ectasia (CAE) cases are common and are regarded as being a kind of CAD. We aimed to investigate, in a case-control study, the relationship between vitamin D and CAE without an associated inflammatory process. Subject and Methods: This study population included 201 patients (CAE group, 121 males; mean age, 61.2±6.4 years) with isolated CAE; and 197 healthy individuals (control group, 119 males; mean age, 62.4±5.8 years), comprising the control group, who had normal coronary arteries. These participants concurrently underwent routine biochemical tests, tests for inflammatory markers, and tests for 25-OH vitamin D in whole-blood draws. These parameters were compared. Results: There are no statistical significance differences among the groups for basic clinical characteristics (p>0.05). Inflammatory markers were recorded and compared to exclude any inflammatory process. All of them were similar, and no statistical significance difference was found. The average parathyroid hormone (PTH) level of patients was higher than the average PTH level in controls (41.8±15.1 pg/mL vs. 19.1±5.81 pg/mL; p<0.001). Also, the average 25-OH vitamin D level of patients was lower than the average 25-OH vitamin D level of controls (14.5±6.3 ng/mL vs. 24.6±9.3 ng/mL; p<0.001). In receiver operating characteristic curve analysis, the observed cut-off value for vitamin D between the control group and patients was 10.8 and 85.6% sensitivity and 75.2% specificity (area under the curve: 0.854, 95% confidence interval: 0.678-0.863). Conclusion: We found that there is an association between vitamin D and CAE in patients who had no inflammatory processes. Our study may provide evidence for the role of vitamin D as a non-inflammatory factor in the pathophysiology of CAE.
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